modifications Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

421 genes co-occuring with the biological term modifications in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACTG1 actin gamma 1
ACYP2 acylphosphatase 2, muscle type
ADIPOQ adiponectin, C1Q and collagen domain containing
AGO2 argonaute RISC catalytic component 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AIRE autoimmune regulator
ALB albumin
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
APOA1 apolipoprotein A-I
APOA5 apolipoprotein A-V
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
APP amyloid beta (A4) precursor protein
APTX aprataxin
AR androgen receptor
ARF1 ADP-ribosylation factor 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARL2 ADP-ribosylation factor-like 2
ASPA aspartoacylase
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATXN2 ataxin 2
BAAT bile acid CoA:amino acid N-acyltransferase
BAG3 BCL2-associated athanogene 3
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP6 bone morphogenetic protein 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BTK Bruton agammaglobulinemia tyrosine kinase
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
CALB1 calbindin 1, 28kDa
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX2 chromobox homolog 2
CBX3 chromobox homolog 3
CBX4 chromobox homolog 4
CBX5 chromobox homolog 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD40LG CD40 ligand
CD63 CD63 molecule
CD7 CD7 molecule
CD70 CD70 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK9 cyclin-dependent kinase 9
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDYL chromodomain protein, Y-like
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CETP cholesteryl ester transfer protein, plasma
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGA glycoprotein hormones, alpha polypeptide
CHD5 chromodomain helicase DNA binding protein 5
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CHMP1A charged multivesicular body protein 1A
CIITA class II, major histocompatibility complex, transactivator
CKB creatine kinase, brain
CLCN1 chloride channel, voltage-sensitive 1
CLCN5 chloride channel, voltage-sensitive 5
CLDN3 claudin 3
CLDN4 claudin 4
CLNS1A chloride channel, nucleotide-sensitive, 1A
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COIL coilin
COL1A1 collagen, type I, alpha 1
CRYGB crystallin, gamma B
CRYGD crystallin, gamma D
CSK c-src tyrosine kinase
CST6 cystatin E/M
CSTB cystatin B (stefin B)
CTBP1 C-terminal binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
CTNND1 catenin (cadherin-associated protein), delta 1
CUX1 cut-like homeobox 1
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DSC1 desmocollin 1
DSTN destrin (actin depolymerizing factor)
DUOX2 dual oxidase 2
DUX4L1 double homeobox 4 like 1
DVL3 dishevelled segment polarity protein 3
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EFNA2 ephrin-A2
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELAVL1 ELAV like RNA binding protein 1
ELN elastin
EP300 E1A binding protein p300
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPOR erythropoietin receptor
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FBXO11 F-box protein 11
FGFR1 fibroblast growth factor receptor 1
FGFR4 fibroblast growth factor receptor 4
FHL2 four and a half LIM domains 2
FMR1 fragile X mental retardation 1
FOXC1 forkhead box C1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FTO fat mass and obesity associated
FURIN furin (paired basic amino acid cleaving enzyme)
FUS FUS RNA binding protein
FXYD1 FXYD domain containing ion transport regulator 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4
GAST gastrin
GATA2 GATA binding protein 2
GCG glucagon
GGT1 gamma-glutamyltransferase 1
GJB2 gap junction protein, beta 2, 26kDa
GLRA1 glycine receptor, alpha 1
GNRHR gonadotropin-releasing hormone receptor
GOLGB1 golgin B1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRIK2 glutamate receptor, ionotropic, kainate 2
GRM1 glutamate receptor, metabotropic 1
GSTP1 glutathione S-transferase pi 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
H2AFZ H2A histone family, member Z
H3F3A H3 histone, family 3A
HAS2-AS1 HAS2 antisense RNA 1
HBB hemoglobin, beta
HDAC1 histone deacetylase 1
HDAC4 histone deacetylase 4
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST1H1C histone cluster 1, H1c
HIST1H1E histone cluster 1, H1e
HIST1H2BG histone cluster 1, H2bg
HIST1H3E histone cluster 1, H3e
HIST2H2AC histone cluster 2, H2ac
HIST2H2BE histone cluster 2, H2be
HIST3H3 histone cluster 3, H3
HIST4H4 histone cluster 4, H4
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HPSE heparanase
HRAS Harvey rat sarcoma viral oncogene homolog
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
HSF1 heat shock transcription factor 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTT huntingtin
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL15 interleukin 15
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL20 interleukin 20
IL23A interleukin 23, alpha subunit p19
IL3 interleukin 3
IL6 interleukin 6
INHBA inhibin, beta A
IRF8 interferon regulatory factor 8
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JDP2 Jun dimerization protein 2
KAT5 K(lysine) acetyltransferase 5
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCNQ1OT1 KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)
KDM1A lysine (K)-specific demethylase 1A
KEAP1 kelch-like ECH-associated protein 1
KIAA1456 KIAA1456
KIF18A kinesin family member 18A
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KLK8 kallikrein-related peptidase 8
KRAS Kirsten rat sarcoma viral oncogene homolog
LEP leptin
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LHCGR luteinizing hormone/choriogonadotropin receptor
LIN9 lin-9 DREAM MuvB core complex component
LIPG lipase, endothelial
LRRK2 leucine-rich repeat kinase 2
LSM10 LSM10, U7 small nuclear RNA associated
LSM11 LSM11, U7 small nuclear RNA associated
LTF lactotransferrin
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAPT microtubule-associated protein tau
MAX MYC associated factor X
MBD4 methyl-CpG binding domain protein 4
MBP myelin basic protein
MCPH1 microcephalin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MECP2 methyl CpG binding protein 2
MEF2C myocyte enhancer factor 2C
MEF2D myocyte enhancer factor 2D
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MGMT O-6-methylguanine-DNA methyltransferase
MIP major intrinsic protein of lens fiber
MIR1260B microRNA 1260b
MIR146A microRNA 146a
MIR199B microRNA 199b
MIR212 microRNA 212
MIR34B microRNA 34b
MIR369 microRNA 369
MIR371A microRNA 371a
MKL1 megakaryoblastic leukemia (translocation) 1
MLH1 mutL homolog 1
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MT-TK tRNA
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
MYBPC3 myosin binding protein C, cardiac
MYC v-myc avian myelocytomatosis viral oncogene homolog
NANOG Nanog homeobox
NARF nuclear prelamin A recognition factor
ND1
NDN necdin, melanoma antigen (MAGE) family member
NF1 neurofibromin 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFYC nuclear transcription factor Y, gamma
NGFR nerve growth factor receptor
NKX2-1 NK2 homeobox 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPRK1 opioid receptor, kappa 1
OPRM1 opioid receptor, mu 1
ORAI1 ORAI calcium release-activated calcium modulator 1
ORM1 orosomucoid 1
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PADI4 peptidyl arginine deiminase, type IV
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDE11A phosphodiesterase 11A
PDIA3 protein disulfide isomerase family A, member 3
PDX1 pancreatic and duodenal homeobox 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIP prolactin-induced protein
PMEL premelanosome protein
PML promyelocytic leukemia
POLL polymerase (DNA directed), lambda
POT1 protection of telomeres 1
POU2F1 POU class 2 homeobox 1
POU5F1 POU class 5 homeobox 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRDM2 PR domain containing 2, with ZNF domain
PRKG1 protein kinase, cGMP-dependent, type I
PRMT5 protein arginine methyltransferase 5
PRMT7 protein arginine methyltransferase 7
PRNP prion protein
PROM1 prominin 1
PRRX2 paired related homeobox 2
PTEN phosphatase and tensin homolog
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PXN paxillin
QPCT glutaminyl-peptide cyclotransferase
RANBP2 RAN binding protein 2
RARA retinoic acid receptor, alpha
RASL10A RAS-like, family 10, member A
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM5 RNA binding motif protein 5
RBM8A RNA binding motif protein 8A
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFX1 regulatory factor X, 1 (influences HLA class II expression)
RNASE3 ribonuclease, RNase A family, 3
ROR1 receptor tyrosine kinase-like orphan receptor 1
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RUNX1 runt-related transcription factor 1
RYR1 ryanodine receptor 1 (skeletal)
S100A4 S100 calcium binding protein A4
SAMHD1 SAM domain and HD domain 1
SCARB1 scavenger receptor class B, member 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCN1A sodium channel, voltage gated, type I alpha subunit
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SIRT4 sirtuin 4
SIRT6 sirtuin 6
SLC26A9 solute carrier family 26 (anion exchanger), member 9
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMAD4 SMAD family member 4
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SOX11 SRY (sex determining region Y)-box 11
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SRY sex determining region Y
SSTR2 somatostatin receptor 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUMO3 small ubiquitin-like modifier 3
TAGLN3 transgelin 3
TARDBP TAR DNA binding protein
TBCA tubulin folding cofactor A
TBX21 T-box 21
TERT telomerase reverse transcriptase
TET2 tet methylcytosine dioxygenase 2
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
THRB thyroid hormone receptor, beta
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNNC1 troponin C type 1 (slow)
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TNPO1 transportin 1
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TP63 tumor protein p63
TRAF3 TNF receptor-associated factor 3
TRH thyrotropin-releasing hormone
TRIM28 tripartite motif containing 28
TRIM33 tripartite motif containing 33
TRIM50 tripartite motif containing 50
TSPY1 testis specific protein, Y-linked 1
TTR transthyretin
TUBB3 tubulin, beta 3 class III
TWIST1 twist family bHLH transcription factor 1
UHRF1 ubiquitin-like with PHD and ring finger domains 1
VCAN versican
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WRN Werner syndrome, RecQ helicase-like
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF154 zinc finger protein 154
ZNF274 zinc finger protein 274
ZNF76 zinc finger protein 76