modification-dependent protein catabolic process Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. (Gene Ontology, GO_0019941)
External Link http://amigo.geneontology.org/amigo/term/GO:0019941
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Genes

370 genes participating in the modification-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC11 anaphase promoting complex subunit 11
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
APC adenomatous polyposis coli
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATXN3 ataxin 3
ATXN3L ataxin 3-like
AURKA aurora kinase A
AURKB aurora kinase B
BAG6 BCL2-associated athanogene 6
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BFAR bifunctional apoptosis regulator
BIRC2 baculoviral IAP repeat containing 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
C19ORF68 chromosome 19 open reading frame 68
C2ORF40 chromosome 2 open reading frame 40
CACUL1 CDK2-associated, cullin domain 1
CCNB1 cyclin B1
CCNF cyclin F
CDC16 cell division cycle 16
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC26 cell division cycle 26
CDC27 cell division cycle 27
CDC34 cell division cycle 34
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CIT citron rho-interacting serine/threonine kinase
CLOCK clock circadian regulator
COPS3 COP9 signalosome subunit 3
CRBN cereblon
CUL1 cullin 1
CUL2 cullin 2
CUL3 cullin 3
CUL4A cullin 4A
CUL4B cullin 4B
CUL5 cullin 5
CUL7 cullin 7
CUL9 cullin 9
CYLD cylindromatosis (turban tumor syndrome)
DDB1 damage-specific DNA binding protein 1, 127kDa
DDIT3 DNA-damage-inducible transcript 3
DERL1 derlin 1
DERL2 derlin 2
DERL3 derlin 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
ERCC8 excision repair cross-complementation group 8
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
FAF1 Fas (TNFRSF6) associated factor 1
FBXL12 F-box and leucine-rich repeat protein 12
FBXL15 F-box and leucine-rich repeat protein 15
FBXL19 F-box and leucine-rich repeat protein 19
FBXL2 F-box and leucine-rich repeat protein 2
FBXL3 F-box and leucine-rich repeat protein 3
FBXL4 F-box and leucine-rich repeat protein 4
FBXL5 F-box and leucine-rich repeat protein 5
FBXL7 F-box and leucine-rich repeat protein 7
FBXO11 F-box protein 11
FBXO2 F-box protein 2
FBXO21 F-box protein 21
FBXO22 F-box protein 22
FBXO31 F-box protein 31
FBXO4 F-box protein 4
FBXO45 F-box protein 45
FBXO5 F-box protein 5
FBXO6 F-box protein 6
FBXO7 F-box protein 7
FBXO8 F-box protein 8
FBXO9 F-box protein 9
FBXW11 F-box and WD repeat domain containing 11
FBXW4 F-box and WD repeat domain containing 4
FBXW5 F-box and WD repeat domain containing 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FBXW9 F-box and WD repeat domain containing 9
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GSK3A glycogen synthase kinase 3 alpha
HDAC6 histone deacetylase 6
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ISG15 ISG15 ubiquitin-like modifier
ITCH itchy E3 ubiquitin protein ligase
JKAMP JNK1/MAPK8-associated membrane protein
KAT5 K(lysine) acetyltransferase 5
KCTD10 potassium channel tetramerization domain containing 10
KCTD13 potassium channel tetramerization domain containing 13
KIAA0368 KIAA0368
KIF14 kinesin family member 14
KLHL20 kelch-like family member 20
KLHL42 kelch-like family member 42
LONP1 lon peptidase 1, mitochondrial
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAN1B1 mannosidase, alpha, class 1B, member 1
MTA1 metastasis associated 1
MVB12A multivesicular body subunit 12A
MVB12B multivesicular body subunit 12B
NDFIP1 Nedd4 family interacting protein 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NEK2 NIMA-related kinase 2
NFE2L2 nuclear factor, erythroid 2-like 2
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NSFL1C NSFL1 (p97) cofactor (p47)
NUB1 negative regulator of ubiquitin-like proteins 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PARK2 parkin RBR E3 ubiquitin protein ligase
PCBP2 poly(rC) binding protein 2
PCNP PEST proteolytic signal containing nuclear protein
PCYOX1 prenylcysteine oxidase 1
PCYOX1L prenylcysteine oxidase 1 like
PINK1 PTEN induced putative kinase 1
PLK1 polo-like kinase 1
PML promyelocytic leukemia
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSME4 proteasome (prosome, macropain) activator subunit 4
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTPN23 protein tyrosine phosphatase, non-receptor type 23
PTTG1 pituitary tumor-transforming 1
RAD23A RAD23 homolog A (S. cerevisiae)
RAD23B RAD23 homolog B (S. cerevisiae)
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RHBDD1 rhomboid domain containing 1
RLIM ring finger protein, LIM domain interacting
RNF103 ring finger protein 103
RNF111 ring finger protein 111
RNF115 ring finger protein 115
RNF121 ring finger protein 121
RNF126 ring finger protein 126
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF175 ring finger protein 175
RNF187 ring finger protein 187
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RNF216 ring finger protein 216
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RNF4 ring finger protein 4
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RNF6 ring finger protein (C3H2C3 type) 6
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPS27A ribosomal protein S27a
SDF2L1 stromal cell-derived factor 2-like 1
SEC61B Sec61 beta subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIAH3 siah E3 ubiquitin protein ligase family member 3
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPOP speckle-type POZ protein
SPOPL speckle-type POZ protein-like
SQSTM1 sequestosome 1
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TBL1X transducin (beta)-like 1X-linked
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM67 transmembrane protein 67
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TOM1L1 target of myb1 (chicken)-like 1
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TOR1A torsin family 1, member A (torsin A)
TRIM13 tripartite motif containing 13
TRIM38 tripartite motif containing 38
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TRIM9 tripartite motif containing 9
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSG101 tumor susceptibility 101
TTC3 tetratricopeptide repeat domain 3
UBA1 ubiquitin-like modifier activating enzyme 1
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBA6 ubiquitin-like modifier activating enzyme 6
UBA7 ubiquitin-like modifier activating enzyme 7
UBAP1 ubiquitin associated protein 1
UBB ubiquitin B
UBC ubiquitin C
UBD ubiquitin D
UBE2A ubiquitin-conjugating enzyme E2A
UBE2B ubiquitin-conjugating enzyme E2B
UBE2C ubiquitin-conjugating enzyme E2C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2G1 ubiquitin-conjugating enzyme E2G 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2H ubiquitin-conjugating enzyme E2H
UBE2I ubiquitin-conjugating enzyme E2I
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2J2 ubiquitin-conjugating enzyme E2, J2
UBE2K ubiquitin-conjugating enzyme E2K
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBE2N ubiquitin-conjugating enzyme E2N
UBE2R2 ubiquitin-conjugating enzyme E2R 2
UBE2S ubiquitin-conjugating enzyme E2S
UBE2U ubiquitin-conjugating enzyme E2U (putative)
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UBE3A ubiquitin protein ligase E3A
UBE4A ubiquitination factor E4A
UBE4B ubiquitination factor E4B
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative)
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UBXN1 UBX domain protein 1
UBXN11 UBX domain protein 11
UBXN2A UBX domain protein 2A
UBXN2B UBX domain protein 2B
UBXN8 UBX domain protein 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UFD1L ubiquitin fusion degradation 1 like (yeast)
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
USP1 ubiquitin specific peptidase 1
USP10 ubiquitin specific peptidase 10
USP11 ubiquitin specific peptidase 11
USP12 ubiquitin specific peptidase 12
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP15 ubiquitin specific peptidase 15
USP16 ubiquitin specific peptidase 16
USP17L1 ubiquitin specific peptidase 17-like family member 1
USP17L10 ubiquitin specific peptidase 17-like family member 10
USP17L11 ubiquitin specific peptidase 17-like family member 11
USP17L12 ubiquitin specific peptidase 17-like family member 12
USP17L13 ubiquitin specific peptidase 17-like family member 13
USP17L17 ubiquitin specific peptidase 17-like family member 17
USP17L18 ubiquitin specific peptidase 17-like family member 18
USP17L19 ubiquitin specific peptidase 17-like family member 19
USP17L2 ubiquitin specific peptidase 17-like family member 2
USP17L20 ubiquitin specific peptidase 17-like family member 20
USP17L21 ubiquitin specific peptidase 17-like family member 21
USP17L22 ubiquitin specific peptidase 17-like family member 22
USP17L3 ubiquitin specific peptidase 17-like family member 3
USP17L4 ubiquitin specific peptidase 17-like family member 4
USP17L5 ubiquitin specific peptidase 17-like family member 5
USP17L7 ubiquitin specific peptidase 17-like family member 7
USP17L8 ubiquitin specific peptidase 17-like family member 8
USP18 ubiquitin specific peptidase 18
USP19 ubiquitin specific peptidase 19
USP2 ubiquitin specific peptidase 2
USP20 ubiquitin specific peptidase 20
USP21 ubiquitin specific peptidase 21
USP22 ubiquitin specific peptidase 22
USP24 ubiquitin specific peptidase 24
USP25 ubiquitin specific peptidase 25
USP26 ubiquitin specific peptidase 26
USP27X ubiquitin specific peptidase 27, X-linked
USP28 ubiquitin specific peptidase 28
USP29 ubiquitin specific peptidase 29
USP3 ubiquitin specific peptidase 3
USP30 ubiquitin specific peptidase 30
USP31 ubiquitin specific peptidase 31
USP32 ubiquitin specific peptidase 32
USP33 ubiquitin specific peptidase 33
USP34 ubiquitin specific peptidase 34
USP35 ubiquitin specific peptidase 35
USP36 ubiquitin specific peptidase 36
USP37 ubiquitin specific peptidase 37
USP38 ubiquitin specific peptidase 38
USP39 ubiquitin specific peptidase 39
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP40 ubiquitin specific peptidase 40
USP42 ubiquitin specific peptidase 42
USP43 ubiquitin specific peptidase 43
USP44 ubiquitin specific peptidase 44
USP45 ubiquitin specific peptidase 45
USP46 ubiquitin specific peptidase 46
USP47 ubiquitin specific peptidase 47
USP48 ubiquitin specific peptidase 48
USP49 ubiquitin specific peptidase 49
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP50 ubiquitin specific peptidase 50
USP51 ubiquitin specific peptidase 51
USP53 ubiquitin specific peptidase 53
USP54 ubiquitin specific peptidase 54
USP6 ubiquitin specific peptidase 6
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP8 ubiquitin specific peptidase 8
USP9X ubiquitin specific peptidase 9, X-linked
USP9Y ubiquitin specific peptidase 9, Y-linked
VCP valosin containing protein
VIMP VCP-interacting membrane selenoprotein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae)
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
WFS1 Wolfram syndrome 1 (wolframin)
WNT1 wingless-type MMTV integration site family, member 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
WWTR1 WW domain containing transcription regulator 1
XBP1 X-box binding protein 1
YOD1 YOD1 deubiquitinase
ZMPSTE24 zinc metallopeptidase STE24
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase
ZNRF3 zinc and ring finger 3