mitotic checkpoint complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20. (Gene Ontology, GO_0033597)
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Genes

69 proteins co-occuring with the mitotic checkpoint complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 2.16101
BUB3 BUB3 mitotic checkpoint protein 1.99333
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 1.98124
CDC20 cell division cycle 20 1.94321
DARS aspartyl-tRNA synthetase 1.62295
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 1.33576
DCC DCC netrin 1 receptor 1.23244
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 1.14546
ARMCX1 armadillo repeat containing, X-linked 1 1.09798
PTTG1 pituitary tumor-transforming 1 1.07359
MAD2L1BP MAD2L1 binding protein 1.0398
TRIP13 thyroid hormone receptor interactor 13 1.02181
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.971297
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 0.925135
ANAPC16 anaphase promoting complex subunit 16 0.904138
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 0.822206
FAT3 FAT atypical cadherin 3 0.814405
MMP10 matrix metallopeptidase 10 0.78004
MCC mutated in colorectal cancers 0.769539
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 0.754983
HELB helicase (DNA) B 0.644001
THOP1 thimet oligopeptidase 1 0.641858
AGTRAP angiotensin II receptor-associated protein 0.609932
CMA1 chymase 1, mast cell 0.568001
REN renin 0.559285
PARK2 parkin RBR E3 ubiquitin protein ligase 0.557629
WNT5B wingless-type MMTV integration site family, member 5B 0.555973
ANAPC4 anaphase promoting complex subunit 4 0.549773
CELA3B chymotrypsin-like elastase family, member 3B 0.53906
SHF Src homology 2 domain containing F 0.505537
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.502288
AURKB aurora kinase B 0.470807
KIF18A kinesin family member 18A 0.457208
SARS seryl-tRNA synthetase 0.453223
MRPL13 mitochondrial ribosomal protein L13 0.44052
RGS3 regulator of G-protein signaling 3 0.43538
RPL12 ribosomal protein L12 0.417294
AGTR1 angiotensin II receptor, type 1 0.41612
NPPA natriuretic peptide A 0.386208
BCAM basal cell adhesion molecule (Lutheran blood group) 0.380429
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.371982
CENPE centromere protein E, 312kDa 0.370833
FLAD1 flavin adenine dinucleotide synthetase 1 0.366623
HFE2 hemochromatosis type 2 (juvenile) 0.366623
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.365477
MLYCD malonyl-CoA decarboxylase 0.362422
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.358609
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.355563
VANGL2 VANGL planar cell polarity protein 2 0.335487
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.328332
LAP3 leucine aminopeptidase 3 0.320826
PGC progastricsin (pepsinogen C) 0.285507
AARS alanyl-tRNA synthetase 0.284769
PCSK7 proprotein convertase subtilisin/kexin type 7 0.271533
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.26385
UBA1 ubiquitin-like modifier activating enzyme 1 0.260931
CASC5 cancer susceptibility candidate 5 0.260566
ANOS1 anosmin 1 0.239916
INS insulin 0.226686
NDC80 NDC80 kinetochore complex component 0.215412
STC1 stanniocalcin 1 0.210203
MDC1 mediator of DNA-damage checkpoint 1 0.205059
RGS4 regulator of G-protein signaling 4 0.201335
TP53 tumor protein p53 0.195681
NTS neurotensin 0.187333
MMP11 matrix metallopeptidase 11 0.18516
ACE angiotensin I converting enzyme 0.180045
KIF5B kinesin family member 5B 0.172201
AREG amphiregulin 0.171673