mitochondrial respiratory chain Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. (Gene Ontology, GO_0005746)
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272 proteins co-occuring with the mitochondrial respiratory chain cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 1.72682
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 1.70014
CS citrate synthase 1.66901
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 1.60826
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 1.50735
CAT catalase 1.47514
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 1.47174
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 1.43331
SURF1 surfeit 1 1.29639
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1.28143
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 1.24445
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 1.23766
UQCRB ubiquinol-cytochrome c reductase binding protein 1.19828
GPX1 glutathione peroxidase 1 1.19571
DHODH dihydroorotate dehydrogenase (quinone) 1.17773
GPX4 glutathione peroxidase 4 1.16696
GPX5 glutathione peroxidase 5 1.16338
ACO2 aconitase 2, mitochondrial 1.10817
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 1.06751
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 1.06246
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 1.06195
FXN frataxin 1.04481
TFAM transcription factor A, mitochondrial 1.04431
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 0.955917
SDHAF1 succinate dehydrogenase complex assembly factor 1 0.954483
SCO2 SCO2 cytochrome c oxidase assembly protein 0.926543
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.90321
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 0.902745
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.899499
ETFDH electron-transferring-flavoprotein dehydrogenase 0.889783
TTC19 tetratricopeptide repeat domain 19 0.886089
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.882399
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.874107
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 0.859852
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.858473
ROMO1 reactive oxygen species modulator 1 0.852042
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 0.841941
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.840105
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.824959
COQ9 coenzyme Q9 0.81257
MXD3 MAX dimerization protein 3 0.798811
COX5B cytochrome c oxidase subunit Vb 0.796062
BOLA3 bolA family member 3 0.794229
HCCS holocytochrome c synthase 0.793313
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 0.786444
PRDX5 peroxiredoxin 5 0.783241
INS insulin 0.774558
UQCRC1 ubiquinol-cytochrome c reductase core protein I 0.774558
COX6C cytochrome c oxidase subunit VIc 0.752263
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 0.731076
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.728836
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.728836
LYRM7 LYR motif containing 7 0.728389
CRYZ crystallin, zeta (quinone reductase) 0.726599
PPARG peroxisome proliferator-activated receptor gamma 0.725705
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.722134
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 0.721688
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 0.718125
AARS2 alanyl-tRNA synthetase 2, mitochondrial 0.710136
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 0.707482
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 0.701304
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.677238
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 0.674196
COX17 COX17 cytochrome c oxidase copper chaperone 0.673762
COX20 COX20 cytochrome c oxidase assembly factor 0.672894
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 0.664232
COX5A cytochrome c oxidase subunit Va 0.661208
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.659913
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial 0.659482
NOS3 nitric oxide synthase 3 (endothelial cell) 0.658188
NOX4 NADPH oxidase 4 0.648291
FGF21 fibroblast growth factor 21 0.647433
DNAH8 dynein, axonemal, heavy chain 8 0.647433
COX11 COX11 cytochrome c oxidase copper chaperone 0.645716
NRF1 nuclear respiratory factor 1 0.641001
COX15 cytochrome c oxidase assembly homolog 15 (yeast) 0.63715
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 0.631171
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.615013
MDH1 malate dehydrogenase 1, NAD (soluble) 0.609509
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.608663
RARS2 arginyl-tRNA synthetase 2, mitochondrial 0.60655
POLG polymerase (DNA directed), gamma 0.606128
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 0.603174
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 0.589714
NFU1 NFU1 iron-sulfur cluster scaffold 0.588456
GSR glutathione reductase 0.585942
PGLS 6-phosphogluconolactonase 0.583012
PUS1 pseudouridylate synthase 1 0.582594
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 0.58134
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.570496
COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) 0.570496
NQO1 NAD(P)H dehydrogenase, quinone 1 0.564262
CYC1 cytochrome c-1 0.560943
BAX BCL2-associated X protein 0.558457
TNF tumor necrosis factor 0.551425
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 0.54936
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 0.538238
COA6 cytochrome c oxidase assembly factor 6 0.538238
FASTKD3 FAST kinase domains 3 0.536183
FASTKD1 FAST kinase domains 1 0.532488
MAOB monoamine oxidase B 0.529208
COX8C cytochrome c oxidase subunit VIIIC 0.526341
SCO1 SCO1 cytochrome c oxidase assembly protein 0.517756
COQ3 coenzyme Q3 methyltransferase 0.51694
RTN4IP1 reticulon 4 interacting protein 1 0.512047
COA5 cytochrome c oxidase assembly factor 5 0.510826
ISCU iron-sulfur cluster assembly enzyme 0.509197
TEAD2 TEA domain family member 2 0.500258
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 0.500258
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.496205
MRPS22 mitochondrial ribosomal protein S22 0.49499
RBM41 RNA binding motif protein 41 0.492966
COQ4 coenzyme Q4 0.485693
HMOX1 heme oxygenase 1 0.483676
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 0.479647
TXN thioredoxin 0.479647
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 0.47442
TK2 thymidine kinase 2, mitochondrial 0.472011
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.471208
ADCK2 aarF domain containing kinase 2 0.465998
SIRT1 sirtuin 1 0.464397
FES FES proto-oncogene, tyrosine kinase 0.463997
FASTKD2 FAST kinase domains 2 0.462798
ADCK4 aarF domain containing kinase 4 0.461998
PHB prohibitin 0.459203
COQ6 coenzyme Q6 monooxygenase 0.458803
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.454019
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 0.453223
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.450438
NADK2 NAD kinase 2, mitochondrial 0.448848
COA3 cytochrome c oxidase assembly factor 3 0.446862
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 0.438542
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 0.437356
DUOX2 dual oxidase 2 0.420036
NDUFA4 NDUFA4, mitochondrial complex associated 0.419644
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.40714
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.397811
SIRT3 sirtuin 3 0.397035
IGLL5 immunoglobulin lambda-like polypeptide 5 0.39626
CDSN corneodesmosin 0.392001
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 0.390455
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.389682
COX19 COX19 cytochrome c oxidase assembly factor 0.389682
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.388523
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) 0.385822
OLFML3 olfactomedin-like 3 0.378122
PARP1 poly (ADP-ribose) polymerase 1 0.367006
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.365859
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 0.365095
MPV17 MpV17 mitochondrial inner membrane protein 0.363949
HADH hydroxyacyl-CoA dehydrogenase 0.363185
YARS tyrosyl-tRNA synthetase 0.358609
CPT2 carnitine palmitoyltransferase 2 0.356705
DGUOK deoxyguanosine kinase 0.356324
TYMP thymidine phosphorylase 0.346071
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.343799
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 0.341529
MIR210 microRNA 210 0.337373
HTT huntingtin 0.332095
PHB2 prohibitin 2 0.327205
L2HGDH L-2-hydroxyglutarate dehydrogenase 0.322325
TP53 tumor protein p53 0.320451
GUCY2C guanylate cyclase 2C 0.317456
SDHAF2 succinate dehydrogenase complex assembly factor 2 0.316334
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.314465
MRPL40 mitochondrial ribosomal protein L40 0.313344
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.311478
NPR1 natriuretic peptide receptor 1 0.309613
NOX1 NADPH oxidase 1 0.305888
DUOX1 dual oxidase 1 0.305515
FH fumarate hydratase 0.304399
MRPS16 mitochondrial ribosomal protein S16 0.304027
FBXL4 F-box and leucine-rich repeat protein 4 0.301425
JUN jun proto-oncogene 0.299197
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 0.298826
MB myoglobin 0.297713
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa 0.291417
CLK1 CDC-like kinase 1 0.290678
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.289569
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 0.28846
MMD monocyte to macrophage differentiation-associated 0.288091
ELANE elastase, neutrophil expressed 0.285876
NOS2 nitric oxide synthase 2, inducible 0.276304
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 0.276304
FDXR ferredoxin reductase 0.275936
ECSIT ECSIT signalling integrator 0.270068
CP ceruloplasmin (ferroxidase) 0.268969
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.268969
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 0.266774
BCL2 B-cell CLL/lymphoma 2 0.264581
COX7B cytochrome c oxidase subunit VIIb 0.26385
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0.260566
VARS valyl-tRNA synthetase 0.259837
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.256197
DDT D-dopachrome tautomerase 0.25438
CHKB choline kinase beta 0.253653
CTU1 cytosolic thiouridylase subunit 1 0.252927
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 0.252202
C12ORF65 chromosome 12 open reading frame 65 0.250026
SESN3 sestrin 3 0.249664
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.24713
CRTC3 CREB regulated transcription coactivator 3 0.244962
EIF2A eukaryotic translation initiation factor 2A, 65kDa 0.24424
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 0.243158
PTCD1 pentatricopeptide repeat domain 1 0.239916
MTO1 mitochondrial tRNA translation optimization 1 0.234174
SPATA21 spermatogenesis associated 21 0.233817
CYBB cytochrome b-245, beta polypeptide 0.232386
GSTA1 glutathione S-transferase alpha 1 0.231672
SAMHD1 SAM domain and HD domain 1 0.229176
ZDHHC8 zinc finger, DHHC-type containing 8 0.225267
UCN urocortin 0.224913
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 0.223143
GSX2 GS homeobox 2 0.220321
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.219969
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 0.214017
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 0.213669
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) 0.211933
SUOX sulfite oxidase 0.211933
TRIT1 tRNA isopentenyltransferase 1 0.210894
ESR2 estrogen receptor 2 (ER beta) 0.210549
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) 0.210549
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 0.210203
ATPIF1 ATPase inhibitory factor 1 0.209858
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.208825
IFNB1 interferon, beta 1, fibroblast 0.207108
SUCLG1 succinate-CoA ligase, alpha subunit 0.206082
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.206082
PYGM phosphorylase, glycogen, muscle 0.204039
AFG3L2 AFG3-like AAA ATPase 2 0.203361
PLA2G1B phospholipase A2, group IB (pancreas) 0.203361
HMOX2 heme oxygenase 2 0.203022
NPTX2 neuronal pentraxin II 0.199325
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 0.198991
HAP1 huntingtin-associated protein 1 0.196339
MFN2 mitofusin 2 0.193719
GSTA4 glutathione S-transferase alpha 4 0.191135
VEGFA vascular endothelial growth factor A 0.18859
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.18702
CYGB cytoglobin 0.185777
FBXO44 F-box protein 44 0.184853
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.184241
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 0.183935
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.180045
PRELID1 PRELI domain containing 1 0.178588
MT-ATP8 ATP synthase F0 subunit 8 0.176024
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.176024
TXNRD1 thioredoxin reductase 1 0.176024
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 0.175745
BCL2L1 BCL2-like 1 0.175188
NUAK1 NUAK family, SNF1-like kinase, 1 0.17141
INSR insulin receptor 0.168349
HSPA4 heat shock 70kDa protein 4 0.168349
TFB2M transcription factor B2, mitochondrial 0.167366
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.165932
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.165231
LIPT1 lipoyltransferase 1 0.16477
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.164089
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.163641
FOXRED1 FAD-dependent oxidoreductase domain containing 1 0.163641
PGC progastricsin (pepsinogen C) 0.163641
LRRK2 leucine-rich repeat kinase 2 0.163641
MAPK8 mitogen-activated protein kinase 8 0.163641
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.161068
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.161068
GCLC glutamate-cysteine ligase, catalytic subunit 0.160658
FSTL1 follistatin-like 1 0.159074
ARHGAP6 Rho GTPase activating protein 6 0.158315
CREB1 cAMP responsive element binding protein 1 0.157943
SIGLEC8 sialic acid binding Ig-like lectin 8 0.157397
GSTA3 glutathione S-transferase alpha 3 0.156688
TAZ tafazzin 0.156513