minocycline-7436 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the minocycline-7436 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACVR1B activin A receptor, type IB
AGGF1 angiogenic factor with G patch and FHA domains 1
AIM1L absent in melanoma 1-like
AK2 adenylate kinase 2
AKAP17A A kinase (PRKA) anchor protein 17A
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APC adenomatous polyposis coli
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ATN1 atrophin 1
BGN biglycan
C8ORF60 chromosome 8 open reading frame 60
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CBX7 chromobox homolog 7
CCDC121 coiled-coil domain containing 121
CDH8 cadherin 8, type 2
COL1A1 collagen, type I, alpha 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSPP1 centrosome and spindle pole associated protein 1
CUL2 cullin 2
DAPK2 death-associated protein kinase 2
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DLG5 discs, large homolog 5 (Drosophila)
DRD2 dopamine receptor D2
DVL2 dishevelled segment polarity protein 2
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
EPHB4 EPH receptor B4
ETV5 ets variant 5
FADS3 fatty acid desaturase 3
FBXL18 F-box and leucine-rich repeat protein 18
FBXL2 F-box and leucine-rich repeat protein 2
FHL1 four and a half LIM domains 1
FRMPD1 FERM and PDZ domain containing 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GADD45G growth arrest and DNA-damage-inducible, gamma
GAMT guanidinoacetate N-methyltransferase
GLRX glutaredoxin (thioltransferase)
GRTP1 growth hormone regulated TBC protein 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GYPB glycophorin B (MNS blood group)
HIPK3 homeodomain interacting protein kinase 3
HLA-DMA major histocompatibility complex, class II, DM alpha
HOXA5 homeobox A5
HSPB6 heat shock protein, alpha-crystallin-related, B6
IDS iduronate 2-sulfatase
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IL4R interleukin 4 receptor
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDM6A lysine (K)-specific demethylase 6A
KLF2 Kruppel-like factor 2
KLF9 Kruppel-like factor 9
KLHL26 kelch-like family member 26
LAMB3 laminin, beta 3
MALT1 MALT1 paracaspase
MAP2K7 mitogen-activated protein kinase kinase 7
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MFAP3L microfibrillar-associated protein 3-like
MID1 midline 1
MPPE1 metallophosphoesterase 1
MYH14 myosin, heavy chain 14, non-muscle
NCOA2 nuclear receptor coactivator 2
NDE1 nudE neurodevelopment protein 1
PAQR6 progestin and adipoQ receptor family member VI
PDLIM7 PDZ and LIM domain 7 (enigma)
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLCD1 phospholipase C, delta 1
POFUT1 protein O-fucosyltransferase 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PTGDS prostaglandin D2 synthase 21kDa (brain)
QKI QKI, KH domain containing, RNA binding
S100A13 S100 calcium binding protein A13
SAPCD1 suppressor APC domain containing 1
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STRN3 striatin, calmodulin binding protein 3
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBKBP1 TBK1 binding protein 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBD thrombomodulin
TMEM212 transmembrane protein 212
TMEM63A transmembrane protein 63A
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TOP3A topoisomerase (DNA) III alpha
TRIM3 tripartite motif containing 3
TRIM62 tripartite motif containing 62
TRIP11 thyroid hormone receptor interactor 11
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WDR25 WD repeat domain 25
WLS wntless Wnt ligand secretion mediator
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF507 zinc finger protein 507
ZNF770 zinc finger protein 770
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ASB9 ankyrin repeat and SOCS box containing 9
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAD5 ATPase family, AAA domain containing 5
BBS7 Bardet-Biedl syndrome 7
BPHL biphenyl hydrolase-like (serine hydrolase)
C10ORF88 chromosome 10 open reading frame 88
C11ORF30 chromosome 11 open reading frame 30
C2ORF44 chromosome 2 open reading frame 44
CAPN5 calpain 5
CCNL2 cyclin L2
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CGREF1 cell growth regulator with EF-hand domain 1
CHST10 carbohydrate sulfotransferase 10
CROT carnitine O-octanoyltransferase
CTSK cathepsin K
CUEDC1 CUE domain containing 1
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAL4 dynein, axonemal, light chain 4
E4F1 E4F transcription factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM50B family with sequence similarity 50, member B
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FHOD1 formin homology 2 domain containing 1
GAB2 GRB2-associated binding protein 2
GAN gigaxonin
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GLI3 GLI family zinc finger 3
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GRB7 growth factor receptor-bound protein 7
ICK intestinal cell (MAK-like) kinase
IL17RA interleukin 17 receptor A
IP6K1 inositol hexakisphosphate kinase 1
IPO13 importin 13
IRAK4 interleukin-1 receptor-associated kinase 4
KIAA0895 KIAA0895
KRT13 keratin 13, type I
LAMA5 laminin, alpha 5
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MBOAT2 membrane bound O-acyltransferase domain containing 2
MCOLN1 mucolipin 1
MED15 mediator complex subunit 15
METTL8 methyltransferase like 8
MON1B MON1 secretory trafficking family member B
MT1F metallothionein 1F
MTCL1 microtubule crosslinking factor 1
MYO1E myosin IE
OGFRL1 opioid growth factor receptor-like 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PANX1 pannexin 1
PARP16 poly (ADP-ribose) polymerase family, member 16
PCSK7 proprotein convertase subtilisin/kexin type 7
PER3 period circadian clock 3
PGPEP1 pyroglutamyl-peptidase I
PLA2G10 phospholipase A2, group X
PLA2G12A phospholipase A2, group XIIA
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLXNA3 plexin A3
PPAN peter pan homolog (Drosophila)
PRKX protein kinase, X-linked
PRODH proline dehydrogenase (oxidase) 1
PSKH1 protein serine kinase H1
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RECQL4 RecQ protein-like 4
RPUSD2 RNA pseudouridylate synthase domain containing 2
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SETD1B SET domain containing 1B
SH2D4A SH2 domain containing 4A
SLC12A9 solute carrier family 12, member 9
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC46A3 solute carrier family 46, member 3
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SP140L SP140 nuclear body protein-like
SREK1IP1 SREK1-interacting protein 1
TBC1D31 TBC1 domain family, member 31
THRAP3 thyroid hormone receptor associated protein 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM184B transmembrane protein 184B
TUBA3C tubulin, alpha 3c
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZBTB3 zinc finger and BTB domain containing 3
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF180 zinc finger protein 180
ZNF184 zinc finger protein 184
ZNF205 zinc finger protein 205
ZNF254 zinc finger protein 254
ZNF365 zinc finger protein 365
ZNF432 zinc finger protein 432