minaprine-4230 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the minaprine-4230 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AFF2 AF4/FMR2 family, member 2
AGFG2 ArfGAP with FG repeats 2
APOE apolipoprotein E
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BLZF1 basic leucine zipper nuclear factor 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCL24 chemokine (C-C motif) ligand 24
CCR7 chemokine (C-C motif) receptor 7
CDH19 cadherin 19, type 2
CDK2 cyclin-dependent kinase 2
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CHRM2 cholinergic receptor, muscarinic 2
CNGB1 cyclic nucleotide gated channel beta 1
CNTNAP2 contactin associated protein-like 2
COL14A1 collagen, type XIV, alpha 1
COL4A6 collagen, type IV, alpha 6
CSHL1 chorionic somatomammotropin hormone-like 1
CYSLTR1 cysteinyl leukotriene receptor 1
DCAF15 DDB1 and CUL4 associated factor 15
DDO D-aspartate oxidase
DOK4 docking protein 4
DOPEY2 dopey family member 2
DST dystonin
ELAC1 elaC ribonuclease Z 1
EPHB1 EPH receptor B1
FABP3 fatty acid binding protein 3, muscle and heart
FAM83E family with sequence similarity 83, member E
FBXO22 F-box protein 22
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FOXF1 forkhead box F1
FZD1 frizzled class receptor 1
GBP2 guanylate binding protein 2, interferon-inducible
GFER growth factor, augmenter of liver regeneration
GPNMB glycoprotein (transmembrane) nmb
GRM8 glutamate receptor, metabotropic 8
GSTA1 glutathione S-transferase alpha 1
HGD homogentisate 1,2-dioxygenase
HOOK1 hook microtubule-tethering protein 1
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
IGF2-AS IGF2 antisense RNA
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
KALRN kalirin, RhoGEF kinase
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KDM5B lysine (K)-specific demethylase 5B
KIF26B kinesin family member 26B
LARP7 La ribonucleoprotein domain family, member 7
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRC75B leucine rich repeat containing 75B
MAP2 microtubule-associated protein 2
MAPK8 mitogen-activated protein kinase 8
MCF2L MCF.2 cell line derived transforming sequence-like
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MIER2 mesoderm induction early response 1, family member 2
MRC2 mannose receptor, C type 2
NCAN neurocan
NOL4 nucleolar protein 4
NOS1 nitric oxide synthase 1 (neuronal)
NPIPB15 nuclear pore complex interacting protein family, member B15
NPR1 natriuretic peptide receptor 1
NPTXR neuronal pentraxin receptor
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCDH8 protocadherin 8
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PKD2L2 polycystic kidney disease 2-like 2
PRAF2 PRA1 domain family, member 2
PRDM14 PR domain containing 14
PRUNE2 prune homolog 2 (Drosophila)
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAB6A RAB6A, member RAS oncogene family
RCE1 Ras converting CAAX endopeptidase 1
RGS5 regulator of G-protein signaling 5
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC39A9 solute carrier family 39, member 9
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SP2 Sp2 transcription factor
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SUGP1 SURP and G patch domain containing 1
SVIL supervillin
SYT5 synaptotagmin V
TBX6 T-box 6
TPSAB1 tryptase alpha/beta 1
TRIL TLR4 interactor with leucine-rich repeats
TRIM29 tripartite motif containing 29
TRIM31 tripartite motif containing 31
TRPC3 transient receptor potential cation channel, subfamily C, member 3
VAX2 ventral anterior homeobox 2
ZNF235 zinc finger protein 235
ZNF415 zinc finger protein 415
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADAM2 ADAM metallopeptidase domain 2
ALOX12 arachidonate 12-lipoxygenase
ANKFY1 ankyrin repeat and FYVE domain containing 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BDNF brain-derived neurotrophic factor
BEX4 brain expressed, X-linked 4
CA9 carbonic anhydrase IX
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CBX8 chromobox homolog 8
CCNJL cyclin J-like
CD68 CD68 molecule
CD70 CD70 molecule
CEP85 centrosomal protein 85kDa
CFAP45 cilia and flagella associated protein 45
CHMP6 charged multivesicular body protein 6
CIDEB cell death-inducing DFFA-like effector b
CLCN5 chloride channel, voltage-sensitive 5
CLDN1 claudin 1
COMP cartilage oligomeric matrix protein
CPNE7 copine VII
CRYBB2P1 crystallin, beta B2 pseudogene 1
CUL9 cullin 9
CUZD1 CUB and zona pellucida-like domains 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
EGLN3 egl-9 family hypoxia-inducible factor 3
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
FBXL15 F-box and leucine-rich repeat protein 15
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FKBPL FK506 binding protein like
FRMPD1 FERM and PDZ domain containing 1
GLS2 glutaminase 2 (liver, mitochondrial)
GPR39 G protein-coupled receptor 39
GRAMD1C GRAM domain containing 1C
HAMP hepcidin antimicrobial peptide
HIST1H1E histone cluster 1, H1e
HIST1H2BO histone cluster 1, H2bo
HIST1H4E histone cluster 1, H4e
IFI6 interferon, alpha-inducible protein 6
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNA17 interferon, alpha 17
IL4R interleukin 4 receptor
ITPKA inositol-trisphosphate 3-kinase A
JUNB jun B proto-oncogene
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LIG4 ligase IV, DNA, ATP-dependent
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC100287590 uncharacterized LOC100287590
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
MATN3 matrilin 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MVP major vault protein
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOTCH4 notch 4
NT5DC3 5'-nucleotidase domain containing 3
NUPR1 nuclear protein, transcriptional regulator, 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
PARP3 poly (ADP-ribose) polymerase family, member 3
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PHEX phosphate regulating endopeptidase homolog, X-linked
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRR4 proline rich 4 (lacrimal)
PRR7 proline rich 7 (synaptic)
RAB36 RAB36, member RAS oncogene family
RBM19 RNA binding motif protein 19
RNF122 ring finger protein 122
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCG5 secretogranin V
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SRD5A3 steroid 5 alpha-reductase 3
THBS3 thrombospondin 3
THRB thyroid hormone receptor, beta
TLR2 toll-like receptor 2
TMEM209 transmembrane protein 209
TMEM242 transmembrane protein 242
TMEM53 transmembrane protein 53
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRIM25 tripartite motif containing 25
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
WDR18 WD repeat domain 18
ZNF227 zinc finger protein 227
ZNF74 zinc finger protein 74
ZNF778 zinc finger protein 778