migraine Gene Set

Dataset HPO Gene-Disease Associations
Category disease or phenotype associations
Type phenotype
Description A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing. (Human Disease Ontology, DOID_6364)
External Link http://compbio.charite.de/hpoweb/showterm?id=HP:0002076
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Genes

105 genes associated with the migraine phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Symbol Name
ACVRL1 activin A receptor type II-like 1
ADRA2B adrenoceptor alpha 2B
AIP aryl hydrocarbon receptor interacting protein
AMACR alpha-methylacyl-CoA racemase
APP amyloid beta (A4) precursor protein
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
C10ORF2 chromosome 10 open reading frame 2
C4A complement component 4A (Rodgers blood group)
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CECR1 cat eye syndrome chromosome region, candidate 1
CNTN2 contactin 2 (axonal)
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COX1
COX2
COX3
CTLA4 cytotoxic T-lymphocyte-associated protein 4
EDNRA endothelin receptor type A
ENG endoglin
EPOR erythropoietin receptor
ERF Ets2 repressor factor
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GCDH glutaryl-CoA dehydrogenase
GDF2 growth differentiation factor 2
HLA-B major histocompatibility complex, class I, B
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
IL10 interleukin 10
IL12B interleukin 12B
IL12RB2 interleukin 12 receptor, beta 2
IL23R interleukin 23 receptor
JAK2 Janus kinase 2
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LPIN2 lipin 2
LRP5 low density lipoprotein receptor-related protein 5
MEFV Mediterranean fever
MLH1 mutL homolog 1
MLX MLX, MAX dimerization protein
MPL MPL proto-oncogene, thrombopoietin receptor
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MT-ND4 NADH dehydrogenase, subunit 4 (complex I)
MT-ND5 NADH dehydrogenase, subunit 5 (complex I)
MT-ND6 NADH dehydrogenase, subunit 6 (complex I)
MT-TF tRNA
MT-TH tRNA
MT-TL1 tRNA
MT-TQ tRNA
MT-TS1 tRNA
MT-TS2 tRNA
MT-TW tRNA
MVK mevalonate kinase
MYD88 myeloid differentiation primary response 88
ND1
NDP Norrie disease (pseudoglioma)
NF2 neurofibromin 2 (merlin)
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOTCH2 notch 2
NOTCH3 notch 3
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEX11B peroxisomal biogenesis factor 11 beta
PGK1 phosphoglycerate kinase 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLG polymerase (DNA directed), gamma
PRRT2 proline-rich transmembrane protein 2
PRTN3 proteinase 3
PTEN phosphatase and tensin homolog
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RPL11 ribosomal protein L11
RPL15 ribosomal protein L15
RPL26 ribosomal protein L26
RPL35A ribosomal protein L35a
RPL5 ribosomal protein L5
RPS10 ribosomal protein S10
RPS17 ribosomal protein S17
RPS19 ribosomal protein S19
RPS24 ribosomal protein S24
RPS26 ribosomal protein S26
RPS29 ribosomal protein S29
RPS7 ribosomal protein S7
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN2A sodium channel, voltage gated, type II alpha subunit
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SMAD4 SMAD family member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
STAT4 signal transducer and activator of transcription 4
STIM1 stromal interaction molecule 1
TET2 tet methylcytosine dioxygenase 2
THPO thrombopoietin
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNXB tenascin XB
TREX1 three prime repair exonuclease 1
TWIST1 twist family bHLH transcription factor 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase