migraine Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1) (Experimental Factor Ontology, EFO_0003821)
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Genes

133 genes co-occuring with the biological term migraine in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADRA2B adrenoceptor alpha 2B
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHSG alpha-2-HS-glycoprotein
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKK1 ankyrin repeat and kinase domain containing 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
AR androgen receptor
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
BACE1 beta-site APP-cleaving enzyme 1
BDNF brain-derived neurotrophic factor
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CALCA calcitonin-related polypeptide alpha
CCR2 chemokine (C-C motif) receptor 2
CD40LG CD40 ligand
CNR1 cannabinoid receptor 1 (brain)
CSNK1D casein kinase 1, delta
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
EDN1 endothelin 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EFHC1 EF-hand domain (C-terminal) containing 1
ENO2 enolase 2 (gamma, neuronal)
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F8 coagulation factor VIII, procoagulant component
FMR1 fragile X mental retardation 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GNAS GNAS complex locus
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIA4 glutamate receptor, ionotropic, AMPA 4
HCRTR1 hypocretin (orexin) receptor 1
HCRTR2 hypocretin (orexin) receptor 2
HFE hemochromatosis
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HNMT histamine N-methyltransferase
HRH3 histamine receptor H3
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
INSR insulin receptor
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNK18 potassium channel, two pore domain subfamily K, member 18
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
LDLR low density lipoprotein receptor
LEP leptin
LPA lipoprotein, Lp(a)
LRP1 low density lipoprotein receptor-related protein 1
LTA lymphotoxin alpha
MAOA monoamine oxidase A
MEP1A meprin A, alpha (PABA peptide hydrolase)
MGR1 Migraine with aura, susceptibility to
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MTDH metadherin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NOTCH4 notch 4
OGG1 8-oxoguanine DNA glycosylase
PANX1 pannexin 1
PANX2 pannexin 2
PANX3 pannexin 3
PGR progesterone receptor
POMC proopiomelanocortin
PON1 paraoxonase 1
PRDM16 PR domain containing 16
PRL prolactin
PRNP prion protein
PRRT2 proline-rich transmembrane protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RHAG Rh-associated glycoprotein
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
S100B S100 calcium binding protein B
SCN1A sodium channel, voltage gated, type I alpha subunit
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
STX1A syntaxin 1A (brain)
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV3 transient receptor potential cation channel, subfamily V, member 3
TSPAN2 tetraspanin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3