migraine Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing. (Human Disease Ontology, DOID_6364)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:6364
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Genes

91 genes associated with the disease migraine in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
LRP1 low density lipoprotein receptor-related protein 1 1.97102
PRDM16 PR domain containing 16 1.75993
TRPM8 transient receptor potential cation channel, subfamily M, member 8 1.74243
MEF2D myocyte enhancer factor 2D 1.5865
SUGCT succinyl-CoA:glutarate-CoA transferase 1.50906
ASTN2 astrotactin 2 1.50906
PHACTR1 phosphatase and actin regulator 1 1.37327
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 1.31635
FBN2 fibrillin 2 1.31635
HAUS1 HAUS augmin-like complex, subunit 1 1.28906
LEPROTL1 leptin receptor overlapping transcript-like 1 1.28906
MRVI1 murine retrovirus integration site 1 homolog 1.28906
PRKG1 protein kinase, cGMP-dependent, type I 1.26953
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 1.25477
MMP17 matrix metallopeptidase 17 (membrane-inserted) 1.24194
KCNK5 potassium channel, two pore domain subfamily K, member 5 1.24194
TGFB1 transforming growth factor, beta 1 1.21019
MRPL37 mitochondrial ribosomal protein L37 1.21019
WASL Wiskott-Aldrich syndrome-like 1.19386
MARCH4 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase 1.19386
KIAA1456 KIAA1456 1.17101
ADAMTSL1 ADAMTS-like 1 1.14629
ZDHHC6 zinc finger, DHHC-type containing 6 1.14463
ARL15 ADP-ribosylation factor-like 15 1.14463
RSU1 Ras suppressor protein 1 1.14463
KANK1 KN motif and ankyrin repeat domains 1 1.10764
NRP1 neuropilin 1 1.10764
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 1.10764
HPSE2 heparanase 2 (inactive) 1.07599
SNX24 sorting nexin 24 1.07599
CDH4 cadherin 4, type 1, R-cadherin (retinal) 1.07599
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.07599
INSIG2 insulin induced gene 2 1.07221
CDH13 cadherin 13 1.04846
KSR2 kinase suppressor of ras 2 1.04846
SV2C synaptic vesicle glycoprotein 2C 1.02476
PHF20 PHD finger protein 20 1.00407
RABGAP1L RAB GTPase activating protein 1-like 1.00407
ADRA1B adrenoceptor alpha 1B 1.00407
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 1.00407
SORBS1 sorbin and SH3 domain containing 1 1.00407
PTPRD protein tyrosine phosphatase, receptor type, D 0.986376
IGLL1 immunoglobulin lambda-like polypeptide 1 0.986376
COX7B2 cytochrome c oxidase subunit VIIb2 0.986376
FRMD4A FERM domain containing 4A 0.986376
SMYD3 SET and MYND domain containing 3 0.983144
STK10 serine/threonine kinase 10 0.971169
FOXP1 forkhead box P1 0.971169
CASZ1 castor zinc finger 1 0.971169
ZNF555 zinc finger protein 555 0.963747
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 0.961634
NF1 neurofibromin 1 0.942098
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.93638
ALK anaplastic lymphoma receptor tyrosine kinase 0.882152
FAM49B family with sequence similarity 49, member B 0.879744
MYLK4 myosin light chain kinase family, member 4 0.879151
ZNF311 zinc finger protein 311 0.87015
NXPH1 neurexophilin 1 0.865448
NAV2 neuron navigator 2 0.86494
COG3 component of oligomeric golgi complex 3 0.844278
GRM7 glutamate receptor, metabotropic 7 0.844278
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.838141
MYO3B myosin IIIB 0.826025
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.793562
ACTN4 actinin, alpha 4 0.787916
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.758762
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.755004
CAMTA1 calmodulin binding transcription activator 1 0.753693
FAM155A family with sequence similarity 155, member A 0.748112
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.735995
STK39 serine threonine kinase 39 0.719687
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.718017
GOLM1 golgi membrane protein 1 0.701191
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 0.692747
IQGAP2 IQ motif containing GTPase activating protein 2 0.691138
ATF7 activating transcription factor 7 0.672789
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.663947
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.589557
CTIF CBP80/20-dependent translation initiation factor 0.534304
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.504779
WAPAL wings apart-like homolog (Drosophila) 0.444585
VSTM4 V-set and transmembrane domain containing 4 0.438494
LIMCH1 LIM and calponin homology domains 1 0.430311
GFRA1 GDNF family receptor alpha 1 0.425585
CDKN2B-AS1 CDKN2B antisense RNA 1 0.422054
CHRM2 cholinergic receptor, muscarinic 2 0.422054
NSD1 nuclear receptor binding SET domain protein 1 0.419335
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 0.417062
BPIFC BPI fold containing family C 0.413127
TBXAS1 thromboxane A synthase 1 (platelet) 0.413127
NBEA neurobeachin 0.411526