midodrine-6804 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the midodrine-6804 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AKR1C1 aldo-keto reductase family 1, member C1
ANP32A-IT1 ANP32A intronic transcript 1
AOAH acyloxyacyl hydrolase (neutrophil)
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
APOM apolipoprotein M
ARHGAP44 Rho GTPase activating protein 44
ARTN artemin
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAIAP3 BAI1-associated protein 3
BCL2 B-cell CLL/lymphoma 2
BEX1 brain expressed, X-linked 1
BLZF1 basic leucine zipper nuclear factor 1
C17ORF59 chromosome 17 open reading frame 59
C2ORF27A chromosome 2 open reading frame 27A
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC14B cell division cycle 14B
CFLAR CASP8 and FADD-like apoptosis regulator
CHKB choline kinase beta
CLDN17 claudin 17
COL6A1 collagen, type VI, alpha 1
DGCR8 DGCR8 microprocessor complex subunit
DIEXF digestive organ expansion factor homolog (zebrafish)
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EGFL7 EGF-like-domain, multiple 7
FAM212B family with sequence similarity 212, member B
FAM214B family with sequence similarity 214, member B
FBXO4 F-box protein 4
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FMOD fibromodulin
GLRA1 glycine receptor, alpha 1
GSAP gamma-secretase activating protein
H2AFX H2A histone family, member X
HYI hydroxypyruvate isomerase (putative)
IGFBP5 insulin-like growth factor binding protein 5
IGLJ3 immunoglobulin lambda joining 3
IL11 interleukin 11
INPP5J inositol polyphosphate-5-phosphatase J
IRF4 interferon regulatory factor 4
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCTD7 potassium channel tetramerization domain containing 7
MAP1S microtubule-associated protein 1S
MARK4 MAP/microtubule affinity-regulating kinase 4
MCTP2 multiple C2 domains, transmembrane 2
MED16 mediator complex subunit 16
MICALL2 MICAL-like 2
MMP3 matrix metallopeptidase 3
MYL10 myosin, light chain 10, regulatory
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYOF myoferlin
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOD1 nucleotide-binding oligomerization domain containing 1
NRSN2 neurensin 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
ORAI2 ORAI calcium release-activated calcium modulator 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PGAP1 post-GPI attachment to proteins 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PNPLA6 patatin-like phospholipase domain containing 6
PPP1R37 protein phosphatase 1, regulatory subunit 37
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTRF polymerase I and transcript release factor
PVR poliovirus receptor
REEP2 receptor accessory protein 2
RND2 Rho family GTPase 2
RNF24 ring finger protein 24
RORC RAR-related orphan receptor C
RPL23AP32 ribosomal protein L23a pseudogene 32
RRBP1 ribosome binding protein 1
RREB1 ras responsive element binding protein 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SSBP1 single-stranded DNA binding protein 1, mitochondrial
TAOK1 TAO kinase 1
TBC1D2 TBC1 domain family, member 2
TGM2 transglutaminase 2
THAP3 THAP domain containing, apoptosis associated protein 3
TJAP1 tight junction associated protein 1 (peripheral)
TMEM120B transmembrane protein 120B
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
UBAP1 ubiquitin associated protein 1
UBE3A ubiquitin protein ligase E3A
UBQLN4 ubiquilin 4
VIPR2 vasoactive intestinal peptide receptor 2
WDR62 WD repeat domain 62
WIZ widely interspaced zinc finger motifs
XAB2 XPA binding protein 2

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACAD10 acyl-CoA dehydrogenase family, member 10
ACADSB acyl-CoA dehydrogenase, short/branched chain
ANKRD36 ankyrin repeat domain 36
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BGLAP bone gamma-carboxyglutamate (gla) protein
BIK BCL2-interacting killer (apoptosis-inducing)
C19ORF73 chromosome 19 open reading frame 73
CA11 carbonic anhydrase XI
CCDC134 coiled-coil domain containing 134
CCNO cyclin O
CDC37L1 cell division cycle 37-like 1
CDKL3 cyclin-dependent kinase-like 3
CENPQ centromere protein Q
CFD complement factor D (adipsin)
CGA glycoprotein hormones, alpha polypeptide
CGREF1 cell growth regulator with EF-hand domain 1
CHRM3 cholinergic receptor, muscarinic 3
CSF1R colony stimulating factor 1 receptor
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DAGLA diacylglycerol lipase, alpha
DGKE diacylglycerol kinase, epsilon 64kDa
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ECHDC2 enoyl CoA hydratase domain containing 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXL2 F-box and leucine-rich repeat protein 2
FOXJ2 forkhead box J2
GAB2 GRB2-associated binding protein 2
GAREM GRB2 associated, regulator of MAPK1
GATA4 GATA binding protein 4
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HIST1H2AK histone cluster 1, H2ak
HIST1H2AL histone cluster 1, H2al
HIST1H2BC histone cluster 1, H2bc
HIST2H2AA3 histone cluster 2, H2aa3
HLA-DMA major histocompatibility complex, class II, DM alpha
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HSPA1L heat shock 70kDa protein 1-like
ICK intestinal cell (MAK-like) kinase
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
LMO2 LIM domain only 2 (rhombotin-like 1)
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MANBA mannosidase, beta A, lysosomal
MECR mitochondrial trans-2-enoyl-CoA reductase
NEK11 NIMA-related kinase 11
NNAT neuronatin
NOL10 nucleolar protein 10
NPFFR1 neuropeptide FF receptor 1
OLFML2A olfactomedin-like 2A
OSGIN1 oxidative stress induced growth inhibitor 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PCDH12 protocadherin 12
PDLIM2 PDZ and LIM domain 2 (mystique)
PICK1 protein interacting with PRKCA 1
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PRODH proline dehydrogenase (oxidase) 1
PRRC1 proline-rich coiled-coil 1
QPCTL glutaminyl-peptide cyclotransferase-like
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB30 RAB30, member RAS oncogene family
RFXAP regulatory factor X-associated protein
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIBC2 RIB43A domain with coiled-coils 2
RIN2 Ras and Rab interactor 2
RNF126P1 ring finger protein 126 pseudogene 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC46A3 solute carrier family 46, member 3
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMR3A submaxillary gland androgen regulated protein 3A
SNX15 sorting nexin 15
SOX12 SRY (sex determining region Y)-box 12
SPRR2B small proline-rich protein 2B
STEAP3 STEAP family member 3, metalloreductase
STMN3 stathmin-like 3
STRN striatin, calmodulin binding protein
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TLN1 talin 1
TRAIP TRAF interacting protein
TRIM5 tripartite motif containing 5
TRIM52 tripartite motif containing 52
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUBA3C tubulin, alpha 3c
USB1 U6 snRNA biogenesis 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VEZT vezatin, adherens junctions transmembrane protein
ZBTB22 zinc finger and BTB domain containing 22
ZDHHC11 zinc finger, DHHC-type containing 11
ZFP69B ZFP69 zinc finger protein B
ZNF675 zinc finger protein 675
ZNF747 zinc finger protein 747