midecamycin-6745 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the midecamycin-6745 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACRV1 acrosomal vesicle protein 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIRE autoimmune regulator
ANGPTL2 angiopoietin-like 2
ANKLE2 ankyrin repeat and LEM domain containing 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BMPR1B bone morphogenetic protein receptor, type IB
BTN3A1 butyrophilin, subfamily 3, member A1
C21ORF2 chromosome 21 open reading frame 2
CACYBP calcyclin binding protein
CADM1 cell adhesion molecule 1
CCDC28B coiled-coil domain containing 28B
CD93 CD93 molecule
CHGA chromogranin A
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
COL10A1 collagen, type X, alpha 1
COL21A1 collagen, type XXI, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COMMD4 COMM domain containing 4
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CYTH4 cytohesin 4
EDA ectodysplasin A
EFNA5 ephrin-A5
EGR4 early growth response 4
FGG fibrinogen gamma chain
FMOD fibromodulin
FOXN2 forkhead box N2
FSHB follicle stimulating hormone, beta polypeptide
GAS7 growth arrest-specific 7
GJA4 gap junction protein, alpha 4, 37kDa
GLRA2 glycine receptor, alpha 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPATCH4 G patch domain containing 4
GPR21 G protein-coupled receptor 21
GUK1 guanylate kinase 1
HLA-DOA major histocompatibility complex, class II, DO alpha
IFFO1 intermediate filament family orphan 1
IL11 interleukin 11
KIF13A kinesin family member 13A
KRAS Kirsten rat sarcoma viral oncogene homolog
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMOD1 leiomodin 1 (smooth muscle)
LRRC17 leucine rich repeat containing 17
LTBP4 latent transforming growth factor beta binding protein 4
LZTS1 leucine zipper, putative tumor suppressor 1
MRPS18C mitochondrial ribosomal protein S18C
MST1L macrophage stimulating 1-like
MT1M metallothionein 1M
MVD mevalonate (diphospho) decarboxylase
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
NELL2 NEL-like 2 (chicken)
NEURL1 neuralized E3 ubiquitin protein ligase 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRG1 neuregulin 1
OR7C1 olfactory receptor, family 7, subfamily C, member 1
PAOX polyamine oxidase (exo-N4-amino)
PARP6 poly (ADP-ribose) polymerase family, member 6
PCDHB3 protocadherin beta 3
PDLIM3 PDZ and LIM domain 3
PHC3 polyhomeotic homolog 3 (Drosophila)
PIGR polymeric immunoglobulin receptor
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLD1 phospholipase D1, phosphatidylcholine-specific
POM121L9P POM121 transmembrane nucleoporin-like 9, pseudogene
POU1F1 POU class 1 homeobox 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRDM9 PR domain containing 9
PROM1 prominin 1
RAB30 RAB30, member RAS oncogene family
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RBM12B RNA binding motif protein 12B
RPS3A ribosomal protein S3A
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RUNX1 runt-related transcription factor 1
SARDH sarcosine dehydrogenase
SCN11A sodium channel, voltage gated, type XI alpha subunit
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SP2 Sp2 transcription factor
SRPK3 SRSF protein kinase 3
TBCD tubulin folding cofactor D
THSD4 thrombospondin, type I, domain containing 4
TIAM2 T-cell lymphoma invasion and metastasis 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM2 tropomyosin 2 (beta)
TRD T cell receptor delta locus
VDAC3 voltage-dependent anion channel 3
ZHX3 zinc fingers and homeoboxes 3
ZNF155 zinc finger protein 155
ZNF224 zinc finger protein 224
ZNF500 zinc finger protein 500

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADAM23 ADAM metallopeptidase domain 23
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADGRF1 adhesion G protein-coupled receptor F1
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AMBRA1 autophagy/beclin-1 regulator 1
APOLD1 apolipoprotein L domain containing 1
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARRB2 arrestin, beta 2
ATAD5 ATPase family, AAA domain containing 5
AURKC aurora kinase C
C11ORF63 chromosome 11 open reading frame 63
CASS4 Cas scaffolding protein family member 4
CCP110 centriolar coiled coil protein 110kDa
CD79A CD79a molecule, immunoglobulin-associated alpha
CHM choroideremia (Rab escort protein 1)
CHMP6 charged multivesicular body protein 6
CLDN14 claudin 14
CNN1 calponin 1, basic, smooth muscle
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCSTAMP dendrocyte expressed seven transmembrane protein
DMTN dematin actin binding protein
DTX2 deltex 2, E3 ubiquitin ligase
ELSPBP1 epididymal sperm binding protein 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM188A family with sequence similarity 188, member A
FAM50B family with sequence similarity 50, member B
FOXA1 forkhead box A1
FRMD8 FERM domain containing 8
FRS3 fibroblast growth factor receptor substrate 3
GIF gastric intrinsic factor (vitamin B synthesis)
GOLGA8B golgin A8 family, member B
HAMP hepcidin antimicrobial peptide
HDAC11 histone deacetylase 11
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOOK1 hook microtubule-tethering protein 1
HOXC4 homeobox C4
HSPB6 heat shock protein, alpha-crystallin-related, B6
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IPO8 importin 8
IQCG IQ motif containing G
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCTD3 potassium channel tetramerization domain containing 3
KDM8 lysine (K)-specific demethylase 8
KIAA0319L KIAA0319-like
KIAA0922 KIAA0922
KLF3 Kruppel-like factor 3 (basic)
LINC00597 long intergenic non-protein coding RNA 597
MANBA mannosidase, beta A, lysosomal
MED15 mediator complex subunit 15
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MICU1 mitochondrial calcium uptake 1
MILR1 mast cell immunoglobulin-like receptor 1
MTSS1L metastasis suppressor 1-like
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NEK11 NIMA-related kinase 11
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAQR6 progestin and adipoQ receptor family member VI
PARPBP PARP1 binding protein
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PISD phosphatidylserine decarboxylase
PLA2G15 phospholipase A2, group XV
PLCD1 phospholipase C, delta 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRSS16 protease, serine, 16 (thymus)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK6 protein tyrosine kinase 6
RAB5B RAB5B, member RAS oncogene family
RHOB ras homolog family member B
RHOBTB2 Rho-related BTB domain containing 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SCUBE3 signal peptide, CUB domain, EGF-like 3
SENP7 SUMO1/sentrin specific peptidase 7
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SRD5A3 steroid 5 alpha-reductase 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STX1A syntaxin 1A (brain)
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGIF1 TGFB-induced factor homeobox 1
TLN1 talin 1
UBOX5 U-box domain containing 5
YOD1 YOD1 deubiquitinase
YY2 YY2 transcription factor
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF358 zinc finger protein 358
ZNF551 zinc finger protein 551
ZNF747 zinc finger protein 747
ZXDB zinc finger, X-linked, duplicated B