mianserin-6260 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the mianserin-6260 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADGRG2 adhesion G protein-coupled receptor G2
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ARHGAP26 Rho GTPase activating protein 26
ARHGAP44 Rho GTPase activating protein 44
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL7A B-cell CLL/lymphoma 7A
BIRC3 baculoviral IAP repeat containing 3
BTF3P11 basic transcription factor 3 pseudogene 11
C11ORF80 chromosome 11 open reading frame 80
C14ORF93 chromosome 14 open reading frame 93
CEP162 centrosomal protein 162kDa
CEP97 centrosomal protein 97kDa
CHRM3 cholinergic receptor, muscarinic 3
DMC1 DNA meiotic recombinase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELOVL2 ELOVL fatty acid elongase 2
EXPH5 exophilin 5
FBXO4 F-box protein 4
FSCN3 fascin actin-bundling protein 3, testicular
GLRX3 glutaredoxin 3
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMOX1 heme oxygenase 1
HOXB7 homeobox B7
HOXC8 homeobox C8
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNA10 interferon, alpha 10
IGHM immunoglobulin heavy constant mu
IL5RA interleukin 5 receptor, alpha
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
JUNB jun B proto-oncogene
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA0930 KIAA0930
KIF26B kinesin family member 26B
KRT31 keratin 31, type I
LOXL3 lysyl oxidase-like 3
LPIN2 lipin 2
LPL lipoprotein lipase
MAP4 microtubule-associated protein 4
MAPK13 mitogen-activated protein kinase 13
MARK4 MAP/microtubule affinity-regulating kinase 4
MBNL2 muscleblind-like splicing regulator 2
MID1 midline 1
MNDA myeloid cell nuclear differentiation antigen
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC3B mucin 3B, cell surface associated
NEK9 NIMA-related kinase 9
NOD1 nucleotide-binding oligomerization domain containing 1
OASL 2'-5'-oligoadenylate synthetase-like
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PCDHGB5 protocadherin gamma subfamily B, 5
PDE4DIP phosphodiesterase 4D interacting protein
PHOX2A paired-like homeobox 2a
PLAC1 placenta-specific 1
PLCH1 phospholipase C, eta 1
PLK4 polo-like kinase 4
PLXNA1 plexin A1
POFUT1 protein O-fucosyltransferase 1
PON3 paraoxonase 3
PPP5C protein phosphatase 5, catalytic subunit
PRB1 proline-rich protein BstNI subfamily 1
PRB3 proline-rich protein BstNI subfamily 3
RGS10 regulator of G-protein signaling 10
RNF122 ring finger protein 122
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
SH2D3A SH2 domain containing 3A
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC12A8 solute carrier family 12, member 8
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A7 solute carrier family 38, member 7
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
TOP3A topoisomerase (DNA) III alpha
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
UBOX5 U-box domain containing 5
UBXN6 UBX domain protein 6
VAMP5 vesicle-associated membrane protein 5
VPRBP Vpr (HIV-1) binding protein
WSB1 WD repeat and SOCS box containing 1
ZNF165 zinc finger protein 165
ZNF174 zinc finger protein 174
ZNF34 zinc finger protein 34
ZNF428 zinc finger protein 428

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ADGRL2 adhesion G protein-coupled receptor L2
AEN apoptosis enhancing nuclease
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ASB9 ankyrin repeat and SOCS box containing 9
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
C17ORF75 chromosome 17 open reading frame 75
CCDC25 coiled-coil domain containing 25
CCDC85C coiled-coil domain containing 85C
CCNL2 cyclin L2
CDKN2AIP CDKN2A interacting protein
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLASP1 cytoplasmic linker associated protein 1
COBL cordon-bleu WH2 repeat protein
CRIPT cysteine-rich PDZ-binding protein
DBR1 debranching RNA lariats 1
DNAAF2 dynein, axonemal, assembly factor 2
DNM1 dynamin 1
DSN1 DSN1, MIS12 kinetochore complex component
DSPP dentin sialophosphoprotein
DTWD1 DTW domain containing 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EFTUD1 elongation factor Tu GTP binding domain containing 1
EVPL envoplakin
F8 coagulation factor VIII, procoagulant component
FCHO1 FCH domain only 1
FOXA1 forkhead box A1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GADD45G growth arrest and DNA-damage-inducible, gamma
HIST1H1E histone cluster 1, H1e
HIST1H2BC histone cluster 1, H2bc
HIST1H3G histone cluster 1, H3g
IL17RA interleukin 17 receptor A
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
JADE3 jade family PHD finger 3
KIAA0355 KIAA0355
KIAA0922 KIAA0922
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRRC42 leucine rich repeat containing 42
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL52 mitochondrial ribosomal protein L52
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYO1E myosin IE
NCSTN nicastrin
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PACS1 phosphofurin acidic cluster sorting protein 1
PARD6A par-6 family cell polarity regulator alpha
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
PYCRL pyrroline-5-carboxylate reductase-like
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RANGRF RAN guanine nucleotide release factor
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RGS19 regulator of G-protein signaling 19
RINT1 RAD50 interactor 1
RNF123 ring finger protein 123
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL13P5 ribosomal protein L13 pseudogene 5
RWDD3 RWD domain containing 3
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SETD8 SET domain containing (lysine methyltransferase) 8
SFT2D2 SFT2 domain containing 2
SLC38A10 solute carrier family 38, member 10
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMA4 glucuronidase, beta pseudogene
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SND1-IT1 SND1 intronic transcript 1
SP3 Sp3 transcription factor
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TMEM180 transmembrane protein 180
TMEM2 transmembrane protein 2
TMEM254 transmembrane protein 254
TPCN1 two pore segment channel 1
TPST2 tyrosylprotein sulfotransferase 2
TPTE transmembrane phosphatase with tensin homology
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TTF2 transcription termination factor, RNA polymerase II
TUBA3D tubulin, alpha 3d
ULBP2 UL16 binding protein 2
VCPKMT valosin containing protein lysine (K) methyltransferase
WDR76 WD repeat domain 76
WLS wntless Wnt ligand secretion mediator
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF253 zinc finger protein 253
ZNF468 zinc finger protein 468