mexiletine-4338 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the mexiletine-4338 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AADAC arylacetamide deacetylase
AIM1L absent in melanoma 1-like
AKAP13 A kinase (PRKA) anchor protein 13
ALB albumin
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALK anaplastic lymphoma receptor tyrosine kinase
AMPD1 adenosine monophosphate deaminase 1
ANGPTL4 angiopoietin-like 4
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
AQP3 aquaporin 3 (Gill blood group)
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BMPR1B bone morphogenetic protein receptor, type IB
CA14 carbonic anhydrase XIV
CCDC132 coiled-coil domain containing 132
CD22 CD22 molecule
CD34 CD34 molecule
CDC14A cell division cycle 14A
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLDN17 claudin 17
CLEC4E C-type lectin domain family 4, member E
CLPS colipase, pancreatic
CNTNAP2 contactin associated protein-like 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CST4 cystatin S
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTNS cystinosin, lysosomal cystine transporter
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DGCR8 DGCR8 microprocessor complex subunit
ERP44 endoplasmic reticulum protein 44
FOXF2 forkhead box F2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GH1 growth hormone 1
GP6 glycoprotein VI (platelet)
GPR19 G protein-coupled receptor 19
GUCA2A guanylate cyclase activator 2A (guanylin)
HFE hemochromatosis
IHH indian hedgehog
IL36G interleukin 36, gamma
IPCEF1 interaction protein for cytohesin exchange factors 1
IQSEC2 IQ motif and Sec7 domain 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KIF25 kinesin family member 25
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KRT2 keratin 2, type II
LAT2 linker for activation of T cells family, member 2
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRRC75B leucine rich repeat containing 75B
MAGEA8 melanoma antigen family A8
MCM3AP minichromosome maintenance complex component 3 associated protein
MMP25 matrix metallopeptidase 25
MTA2 metastasis associated 1 family, member 2
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NECAB2 N-terminal EF-hand calcium binding protein 2
NFASC neurofascin
NPTX2 neuronal pentraxin II
NR0B1 nuclear receptor subfamily 0, group B, member 1
NT5M 5',3'-nucleotidase, mitochondrial
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PASK PAS domain containing serine/threonine kinase
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKNOX2 PBX/knotted 1 homeobox 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAC4 placenta-specific 4
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRKCE protein kinase C, epsilon
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYY peptide YY
RAB6B RAB6B, member RAS oncogene family
RAD52 RAD52 homolog (S. cerevisiae)
RANBP1 RAN binding protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
REEP2 receptor accessory protein 2
RET ret proto-oncogene
RFPL2 ret finger protein-like 2
RND1 Rho family GTPase 1
RNF122 ring finger protein 122
SCLY selenocysteine lyase
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SIRT4 sirtuin 4
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
SNCAIP synuclein, alpha interacting protein
SOX21 SRY (sex determining region Y)-box 21
SPP1 secreted phosphoprotein 1
SULT4A1 sulfotransferase family 4A, member 1
TAS2R4 taste receptor, type 2, member 4
TGM3 transglutaminase 3
TRIM14 tripartite motif containing 14
TSC22D2 TSC22 domain family, member 2
UBE2I ubiquitin-conjugating enzyme E2I

decreased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ADAT1 adenosine deaminase, tRNA-specific 1
AHDC1 AT hook, DNA binding motif, containing 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATAT1 alpha tubulin acetyltransferase 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
C14ORF79 chromosome 14 open reading frame 79
C1ORF54 chromosome 1 open reading frame 54
C1S complement component 1, s subcomponent
C3 complement component 3
C4ORF29 chromosome 4 open reading frame 29
CAMTA2 calmodulin binding transcription activator 2
CASKIN2 CASK interacting protein 2
CCDC186 coiled-coil domain containing 186
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDT1 chromatin licensing and DNA replication factor 1
CFAP69 cilia and flagella associated protein 69
CPEB1 cytoplasmic polyadenylation element binding protein 1
CREB5 cAMP responsive element binding protein 5
CRY2 cryptochrome circadian clock 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DBF4B DBF4 zinc finger B
DEAF1 DEAF1 transcription factor
DLL3 delta-like 3 (Drosophila)
DOK5 docking protein 5
EPHA7 EPH receptor A7
ERCC4 excision repair cross-complementation group 4
FAM102A family with sequence similarity 102, member A
FAM53C family with sequence similarity 53, member C
FGF23 fibroblast growth factor 23
FURIN furin (paired basic amino acid cleaving enzyme)
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GLB1L galactosidase, beta 1-like
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HAUS6 HAUS augmin-like complex, subunit 6
HIST1H2AJ histone cluster 1, H2aj
HOMER2 homer scaffolding protein 2
HSPA1L heat shock 70kDa protein 1-like
HYAL3 hyaluronoglucosaminidase 3
IPO8 importin 8
KCTD17 potassium channel tetramerization domain containing 17
KDM4D lysine (K)-specific demethylase 4D
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC37A3 leucine rich repeat containing 37, member A3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MED15 mediator complex subunit 15
MFGE8 milk fat globule-EGF factor 8 protein
MID1IP1 MID1 interacting protein 1
MUC3B mucin 3B, cell surface associated
NABP1 nucleic acid binding protein 1
NID2 nidogen 2 (osteonidogen)
NKX3-2 NK3 homeobox 2
NME5 NME/NM23 family member 5
NRGN neurogranin (protein kinase C substrate, RC3)
NUP62CL nucleoporin 62kDa C-terminal like
OSMR oncostatin M receptor
PENK proenkephalin
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POLL polymerase (DNA directed), lambda
POMT2 protein-O-mannosyltransferase 2
PTK6 protein tyrosine kinase 6
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB5B RAB5B, member RAS oncogene family
SCIN scinderin
SETD1A SET domain containing 1A
SH3GLB2 SH3-domain GRB2-like endophilin B2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SOD3 superoxide dismutase 3, extracellular
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STAB2 stabilin 2
STON1 stonin 1
STRA6 stimulated by retinoic acid 6
STRN4 striatin, calmodulin binding protein 4
TEP1 telomerase-associated protein 1
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TLN1 talin 1
TMEM209 transmembrane protein 209
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TPCN1 two pore segment channel 1
TTN titin
UNKL unkempt family zinc finger-like
USP20 ubiquitin specific peptidase 20
WDR25 WD repeat domain 25
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF219 zinc finger protein 219
ZNF492 zinc finger protein 492
ZNF652 zinc finger protein 652
ZNF711 zinc finger protein 711
ZNF76 zinc finger protein 76
ZNF768 zinc finger protein 768