mexiletine-3862 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the mexiletine-3862 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
AGFG2 ArfGAP with FG repeats 2
APOC1 apolipoprotein C-I
ARHGAP35 Rho GTPase activating protein 35
ARTN artemin
ASPN asporin
ATP7A ATPase, Cu++ transporting, alpha polypeptide
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBX2 chromobox homolog 2
CEP295 centrosomal protein 295kDa
CNN1 calponin 1, basic, smooth muscle
CNTFR ciliary neurotrophic factor receptor
COL1A1 collagen, type I, alpha 1
COPA coatomer protein complex, subunit alpha
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DAO D-amino-acid oxidase
DAPK3 death-associated protein kinase 3
DICER1 dicer 1, ribonuclease type III
DIO2 deiodinase, iodothyronine, type II
DIXDC1 DIX domain containing 1
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DSC2 desmocollin 2
DST dystonin
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
FAM120C family with sequence similarity 120C
FKRP fukutin related protein
FLOT1 flotillin 1
FN1 fibronectin 1
FOSL2 FOS-like antigen 2
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPER1 G protein-coupled estrogen receptor 1
GPR137 G protein-coupled receptor 137
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSN gelsolin
HFE hemochromatosis
HIPK2 homeodomain interacting protein kinase 2
HOXB5 homeobox B5
HTATSF1 HIV-1 Tat specific factor 1
IL17RC interleukin 17 receptor C
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KMT2A lysine (K)-specific methyltransferase 2A
LMAN1 lectin, mannose-binding, 1
LOXL2 lysyl oxidase-like 2
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MCL1 myeloid cell leukemia 1
MCTP1 multiple C2 domains, transmembrane 1
METTL7A methyltransferase like 7A
MON2 MON2 homolog (S. cerevisiae)
MRPL41 mitochondrial ribosomal protein L41
MTMR8 myotubularin related protein 8
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOP16 NOP16 nucleolar protein
PAPPA2 pappalysin 2
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCH1 phospholipase C, eta 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
PRKD1 protein kinase D1
PSAT1 phosphoserine aminotransferase 1
RB1 retinoblastoma 1
RCAN3 RCAN family member 3
RLN1 relaxin 1
RNF6 ring finger protein (C3H2C3 type) 6
RXRB retinoid X receptor, beta
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIRT4 sirtuin 4
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A4 solute carrier family 16, member 4
SLC17A2 solute carrier family 17, member 2
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SOX4 SRY (sex determining region Y)-box 4
SP1 Sp1 transcription factor
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULT4A1 sulfotransferase family 4A, member 1
TADA2A transcriptional adaptor 2A
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TGM2 transglutaminase 2
TM6SF1 transmembrane 6 superfamily member 1
TMEM259 transmembrane protein 259
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TYRO3 TYRO3 protein tyrosine kinase
USP34 ubiquitin specific peptidase 34
WDR55 WD repeat domain 55
WNT10B wingless-type MMTV integration site family, member 10B
XCR1 chemokine (C motif) receptor 1
ZBTB43 zinc finger and BTB domain containing 43
ZER1 zyg-11 related, cell cycle regulator
ZFP64 ZFP64 zinc finger protein
ZNF324 zinc finger protein 324
ZNF384 zinc finger protein 384

decreased expression

Symbol Name
ACTL8 actin-like 8
ADAP2 ArfGAP with dual PH domains 2
ADCY7 adenylate cyclase 7
AGMAT agmatine ureohydrolase (agmatinase)
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AMH anti-Mullerian hormone
AMPD1 adenosine monophosphate deaminase 1
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
BIRC7 baculoviral IAP repeat containing 7
C14ORF79 chromosome 14 open reading frame 79
C8ORF60 chromosome 8 open reading frame 60
C9ORF9 chromosome 9 open reading frame 9
CCDC88C coiled-coil domain containing 88C
CCDC9 coiled-coil domain containing 9
CD80 CD80 molecule
CD8A CD8a molecule
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLSPN claspin
CNR2 cannabinoid receptor 2 (macrophage)
CORO7 coronin 7
CRY2 cryptochrome circadian clock 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL9 cullin 9
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EFNA3 ephrin-A3
EMID1 EMI domain containing 1
ENOX1 ecto-NOX disulfide-thiol exchanger 1
ERCC5 excision repair cross-complementation group 5
FAM76A family with sequence similarity 76, member A
FGF4 fibroblast growth factor 4
FLJ22184
FOXN2 forkhead box N2
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H1D histone cluster 1, H1d
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IFNA14 interferon, alpha 14
IFT140 intraflagellar transport 140
IGFBP6 insulin-like growth factor binding protein 6
IL12RB1 interleukin 12 receptor, beta 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INPP1 inositol polyphosphate-1-phosphatase
KIAA1107 KIAA1107
LHX6 LIM homeobox 6
LIME1 Lck interacting transmembrane adaptor 1
LOXL3 lysyl oxidase-like 3
MATK megakaryocyte-associated tyrosine kinase
MFAP2 microfibrillar-associated protein 2
MTA2 metastasis associated 1 family, member 2
NEK11 NIMA-related kinase 11
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPPA natriuretic peptide A
NPTX1 neuronal pentraxin I
OSGIN1 oxidative stress induced growth inhibitor 1
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PITX1 paired-like homeodomain 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLSCR4 phospholipid scramblase 4
PP14571 uncharacterized LOC100130449
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PTPRE protein tyrosine phosphatase, receptor type, E
RAB33B RAB33B, member RAS oncogene family
RAB36 RAB36, member RAS oncogene family
RAB40C RAB40C, member RAS oncogene family
RGS19 regulator of G-protein signaling 19
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF141 ring finger protein 141
RPL10L ribosomal protein L10-like
SCGB2A2 secretoglobin, family 2A, member 2
SIPA1 signal-induced proliferation-associated 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMIM14 small integral membrane protein 14
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STON1 stonin 1
STRA6 stimulated by retinoic acid 6
TBC1D2 TBC1 domain family, member 2
TCP10 t-complex 10
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAIP TRAF interacting protein
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSPYL2 TSPY-like 2
TUBA4B tubulin, alpha 4b
TUBG2 tubulin, gamma 2
XAB2 XPA binding protein 2
YY2 YY2 transcription factor
ZFP37 ZFP37 zinc finger protein
ZNF358 zinc finger protein 358
ZNF516 zinc finger protein 516
ZNF532 zinc finger protein 532
ZNF639 zinc finger protein 639
ZNF76 zinc finger protein 76