metyrapone-6447 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the metyrapone-6447 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACTL8 actin-like 8
ADAM20 ADAM metallopeptidase domain 20
ADAM22 ADAM metallopeptidase domain 22
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARTN artemin
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP10A ATPase, class V, type 10A
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BCL2L10 BCL2-like 10 (apoptosis facilitator)
C5ORF42 chromosome 5 open reading frame 42
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD82 CD82 molecule
CDC25A cell division cycle 25A
CDK3 cyclin-dependent kinase 3
CEP350 centrosomal protein 350kDa
CLTA clathrin, light chain A
COMT catechol-O-methyltransferase
CPB2 carboxypeptidase B2 (plasma)
CSHL1 chorionic somatomammotropin hormone-like 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DFNB31 deafness, autosomal recessive 31
DICER1 dicer 1, ribonuclease type III
EDNRB endothelin receptor type B
EDRF1 erythroid differentiation regulatory factor 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EMP3 epithelial membrane protein 3
F2RL3 coagulation factor II (thrombin) receptor-like 3
FGB fibrinogen beta chain
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP10 FK506 binding protein 10, 65 kDa
FLT3LG fms-related tyrosine kinase 3 ligand
FOSL2 FOS-like antigen 2
FOXL1 forkhead box L1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAL galanin/GMAP prepropeptide
GEM GTP binding protein overexpressed in skeletal muscle
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GRIP2 glutamate receptor interacting protein 2
GSPT1 G1 to S phase transition 1
HFE hemochromatosis
HOXA10 homeobox A10
HPX hemopexin
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INO80B INO80 complex subunit B
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KIAA0368 KIAA0368
KIF21B kinesin family member 21B
KIF25 kinesin family member 25
KLK8 kallikrein-related peptidase 8
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT17 keratin 17, type I
LIN7A lin-7 homolog A (C. elegans)
LRRC14 leucine rich repeat containing 14
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAB21L1 mab-21-like 1 (C. elegans)
MALL mal, T-cell differentiation protein-like
MFGE8 milk fat globule-EGF factor 8 protein
MIP major intrinsic protein of lens fiber
MRC2 mannose receptor, C type 2
MYB v-myb avian myeloblastosis viral oncogene homolog
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NIPAL3 NIPA-like domain containing 3
NOX1 NADPH oxidase 1
NPR3 natriuretic peptide receptor 3
NR2E3 nuclear receptor subfamily 2, group E, member 3
NXF2 nuclear RNA export factor 2
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PHTF2 putative homeodomain transcription factor 2
PIGR polymeric immunoglobulin receptor
PLD3 phospholipase D family, member 3
POU2F2 POU class 2 homeobox 2
PPEF1 protein phosphatase, EF-hand calcium binding domain 1
PRAMEF11 PRAME family member 11
PRKCA protein kinase C, alpha
PTAFR platelet-activating factor receptor
R3HDM1 R3H domain containing 1
RIMS2 regulating synaptic membrane exocytosis 2
RUSC2 RUN and SH3 domain containing 2
SCAPER S-phase cyclin A-associated protein in the ER
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SHOX2 short stature homeobox 2
SLC45A2 solute carrier family 45, member 2
SLC6A16 solute carrier family 6, member 16
SPTBN2 spectrin, beta, non-erythrocytic 2
TEX40 testis expressed 40
TGM3 transglutaminase 3
TMEM259 transmembrane protein 259
TRAK1 trafficking protein, kinesin binding 1
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
UNC5B unc-5 homolog B (C. elegans)
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZNF304 zinc finger protein 304
ZNF384 zinc finger protein 384

decreased expression

Symbol Name
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARC activity-regulated cytoskeleton-associated protein
ASPN asporin
ATXN2 ataxin 2
BAHD1 bromo adjacent homology domain containing 1
BTF3P12 basic transcription factor 3 pseudogene 12
C10ORF95 chromosome 10 open reading frame 95
C1ORF21 chromosome 1 open reading frame 21
CD3D CD3d molecule, delta (CD3-TCR complex)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLDN4 claudin 4
CORO2A coronin, actin binding protein, 2A
CXXC4 CXXC finger protein 4
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
ENO2 enolase 2 (gamma, neuronal)
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC6 excision repair cross-complementation group 6
ERF Ets2 repressor factor
F2R coagulation factor II (thrombin) receptor
FAM155A family with sequence similarity 155, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FLT4 fms-related tyrosine kinase 4
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GBP2 guanylate binding protein 2, interferon-inducible
GPC3 glypican 3
GPR87 G protein-coupled receptor 87
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIRA histone cell cycle regulator
HIST1H2AM histone cluster 1, H2am
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMOX1 heme oxygenase 1
HOXC8 homeobox C8
IL12RB1 interleukin 12 receptor, beta 1
IL15RA interleukin 15 receptor, alpha
INCENP inner centromere protein antigens 135/155kDa
IRAK4 interleukin-1 receptor-associated kinase 4
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM8 lysine (K)-specific demethylase 8
LINC00597 long intergenic non-protein coding RNA 597
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC729164 hCG1732469
LRRC20 leucine rich repeat containing 20
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MCC mutated in colorectal cancers
MECR mitochondrial trans-2-enoyl-CoA reductase
MED31 mediator complex subunit 31
NBEAL2 neurobeachin-like 2
NCALD neurocalcin delta
NEK11 NIMA-related kinase 11
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
P3H1 prolyl 3-hydroxylase 1
PACS1 phosphofurin acidic cluster sorting protein 1
PDIA3 protein disulfide isomerase family A, member 3
PHACTR4 phosphatase and actin regulator 4
PHC1 polyhomeotic homolog 1 (Drosophila)
PLD2 phospholipase D2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POLH polymerase (DNA directed), eta
RCAN3 RCAN family member 3
RPAP2 RNA polymerase II associated protein 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SFRP5 secreted frizzled-related protein 5
SLMO1 slowmo homolog 1 (Drosophila)
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAOK1 TAO kinase 1
TCTN1 tectonic family member 1
THBS3 thrombospondin 3
TMEM254 transmembrane protein 254
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOM1 target of myb1 (chicken)
TPST2 tyrosylprotein sulfotransferase 2
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSPAN1 tetraspanin 1
UNC93B1 unc-93 homolog B1 (C. elegans)
USP27X ubiquitin specific peptidase 27, X-linked
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VASP vasodilator-stimulated phosphoprotein
VIM vimentin
WDR91 WD repeat domain 91
WLS wntless Wnt ligand secretion mediator
ZFP30 ZFP30 zinc finger protein
ZNF204P zinc finger protein 204, pseudogene
ZNF254 zinc finger protein 254
ZNF350 zinc finger protein 350
ZNF428 zinc finger protein 428
ZNF480 zinc finger protein 480
ZNF492 zinc finger protein 492
ZNF74 zinc finger protein 74
ZNF862 zinc finger protein 862