metyrapone-4606 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the metyrapone-4606 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACAA2 acetyl-CoA acyltransferase 2
ADGRL3 adhesion G protein-coupled receptor L3
ADGRL4 adhesion G protein-coupled receptor L4
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANKRD6 ankyrin repeat domain 6
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARTN artemin
BHMT2 betaine--homocysteine S-methyltransferase 2
BMPR1B bone morphogenetic protein receptor, type IB
BPY2 basic charge, Y-linked, 2
C18ORF25 chromosome 18 open reading frame 25
C1ORF54 chromosome 1 open reading frame 54
C5ORF42 chromosome 5 open reading frame 42
C6ORF10 chromosome 6 open reading frame 10
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CARTPT CART prepropeptide
CCDC28B coiled-coil domain containing 28B
CCR4 chemokine (C-C motif) receptor 4
CCR7 chemokine (C-C motif) receptor 7
CD19 CD19 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDHR5 cadherin-related family member 5
CDK13 cyclin-dependent kinase 13
CEMP1 cementum protein 1
CLTCL1 clathrin, heavy chain-like 1
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CRISP2 cysteine-rich secretory protein 2
CRYBA2 crystallin, beta A2
DDN dendrin
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
EPB42 erythrocyte membrane protein band 4.2
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FLJ11292
FOXD2 forkhead box D2
FYB FYN binding protein
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GIF gastric intrinsic factor (vitamin B synthesis)
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR52 G protein-coupled receptor 52
HNMT histamine N-methyltransferase
HOXB2 homeobox B2
HPGDS hematopoietic prostaglandin D synthase
HRG histidine-rich glycoprotein
IGH immunoglobulin heavy locus
IGL immunoglobulin lambda locus
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL2 interleukin 2
ING2 inhibitor of growth family, member 2
JPH3 junctophilin 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KLHL25 kelch-like family member 25
LARGE like-glycosyltransferase
LDAH lipid droplet associated hydrolase
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LOC390998 ribosomal protein L10 pseudogene
LPL lipoprotein lipase
MCF2 MCF.2 cell line derived transforming sequence
MLXIP MLX interacting protein
MSR1 macrophage scavenger receptor 1
NF1 neurofibromin 1
NME8 NME/NM23 family member 8
NPR1 natriuretic peptide receptor 1
PAX8 paired box 8
PCDH1 protocadherin 1
PDE4DIP phosphodiesterase 4D interacting protein
PDGFB platelet-derived growth factor beta polypeptide
PDLIM3 PDZ and LIM domain 3
PEX3 peroxisomal biogenesis factor 3
PHF20L1 PHD finger protein 20-like 1
PNPLA2 patatin-like phospholipase domain containing 2
POU2F2 POU class 2 homeobox 2
PSCA prostate stem cell antigen
PSG9 pregnancy specific beta-1-glycoprotein 9
PURA purine-rich element binding protein A
RCE1 Ras converting CAAX endopeptidase 1
RDH8 retinol dehydrogenase 8 (all-trans)
RHO rhodopsin
RNF122 ring finger protein 122
RPL23AP32 ribosomal protein L23a pseudogene 32
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
SCN10A sodium channel, voltage gated, type X alpha subunit
SEMG2 semenogelin II
SEZ6L seizure related 6 homolog (mouse)-like
SKIL SKI-like proto-oncogene
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPRR1A small proline-rich protein 1A
SRRT serrate, RNA effector molecule
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
SYT17 synaptotagmin XVII
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TSPY1 testis specific protein, Y-linked 1
TUBA4B tubulin, alpha 4b
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADAM15 ADAM metallopeptidase domain 15
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADGRF1 adhesion G protein-coupled receptor F1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMT aminomethyltransferase
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BCORL1 BCL6 corepressor-like 1
BGLAP bone gamma-carboxyglutamate (gla) protein
C4ORF19 chromosome 4 open reading frame 19
C5ORF45 chromosome 5 open reading frame 45
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD70 CD70 molecule
CENPT centromere protein T
CEP85 centrosomal protein 85kDa
CORO2A coronin, actin binding protein, 2A
DCAF13 DDB1 and CUL4 associated factor 13
DNM3 dynamin 3
DTX2 deltex 2, E3 ubiquitin ligase
EPHX2 epoxide hydrolase 2, cytoplasmic
FBXW12 F-box and WD repeat domain containing 12
FZD3 frizzled class receptor 3
FZD8 frizzled class receptor 8
GAB2 GRB2-associated binding protein 2
GLS2 glutaminase 2 (liver, mitochondrial)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPR39 G protein-coupled receptor 39
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
HDAC7 histone deacetylase 7
HIST1H2AK histone cluster 1, H2ak
HOOK1 hook microtubule-tethering protein 1
IL17RA interleukin 17 receptor A
KCTD20 potassium channel tetramerization domain containing 20
KIAA0513 KIAA0513
LMCD1 LIM and cysteine-rich domains 1
MBTD1 mbt domain containing 1
MGC12488
MITF microphthalmia-associated transcription factor
MXD3 MAX dimerization protein 3
MYLIP myosin regulatory light chain interacting protein
NAG18 NAG18 mRNA
NDP Norrie disease (pseudoglioma)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOL12 nucleolar protein 12
NOL6 nucleolar protein 6 (RNA-associated)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PHC1 polyhomeotic homolog 1 (Drosophila)
PLCD1 phospholipase C, delta 1
PLD2 phospholipase D2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PODXL2 podocalyxin-like 2
POLM polymerase (DNA directed), mu
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROSER1 proline and serine rich 1
RAP1GAP2 RAP1 GTPase activating protein 2
RHOBTB2 Rho-related BTB domain containing 2
RIN1 Ras and Rab interactor 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RUSC2 RUN and SH3 domain containing 2
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPIDR scaffolding protein involved in DNA repair
SSBP3 single stranded DNA binding protein 3
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK16 serine/threonine kinase 16
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCTN1 tectonic family member 1
TMEM53 transmembrane protein 53
TRIM66 tripartite motif containing 66
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSKU tsukushi, small leucine rich proteoglycan
TTC17 tetratricopeptide repeat domain 17
TUBG2 tubulin, gamma 2
UIMC1 ubiquitin interaction motif containing 1
WDR76 WD repeat domain 76
ZBTB39 zinc finger and BTB domain containing 39
ZC3H12A zinc finger CCCH-type containing 12A
ZFP30 ZFP30 zinc finger protein
ZNF177 zinc finger protein 177
ZNF204P zinc finger protein 204, pseudogene
ZNF222 zinc finger protein 222
ZNF227 zinc finger protein 227
ZNF34 zinc finger protein 34