metoprolol-6846 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the metoprolol-6846 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGFG2 ArfGAP with FG repeats 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANKLE2 ankyrin repeat and LEM domain containing 2
AOC2 amine oxidase, copper containing 2 (retina-specific)
APOE apolipoprotein E
APOM apolipoprotein M
CCDC68 coiled-coil domain containing 68
CCDC7 coiled-coil domain containing 7
CD6 CD6 molecule
CDIP1 cell death-inducing p53 target 1
CLIC2 chloride intracellular channel 2
CLTA clathrin, light chain A
COL16A1 collagen, type XVI, alpha 1
COL19A1 collagen, type XIX, alpha 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DOCK5 dedicator of cytokinesis 5
DOK4 docking protein 4
EDN1 endothelin 1
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ERAP1 endoplasmic reticulum aminopeptidase 1
FLJ11710 uncharacterized protein FLJ11710
GM2A GM2 ganglioside activator
GPATCH4 G patch domain containing 4
GPER1 G protein-coupled estrogen receptor 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIPK2 homeodomain interacting protein kinase 2
HIST1H1T histone cluster 1, H1t
HLA-DOA major histocompatibility complex, class II, DO alpha
HNMT histamine N-methyltransferase
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFNA14 interferon, alpha 14
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1B interleukin 1, beta
IL5RA interleukin 5 receptor, alpha
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JAM3 junctional adhesion molecule 3
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM4B lysine (K)-specific demethylase 4B
KHSRP KH-type splicing regulatory protein
LAMB4 laminin, beta 4
LAMC2 laminin, gamma 2
LAMP3 lysosomal-associated membrane protein 3
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
MBNL2 muscleblind-like splicing regulator 2
MED16 mediator complex subunit 16
MEG3 maternally expressed 3 (non-protein coding)
MYL10 myosin, light chain 10, regulatory
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAT6 N-acetyltransferase 6 (GCN5-related)
NRP1 neuropilin 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OXCT2 3-oxoacid CoA transferase 2
PDE12 phosphodiesterase 12
PDE4DIP phosphodiesterase 4D interacting protein
PDZD2 PDZ domain containing 2
PIGR polymeric immunoglobulin receptor
PLAA phospholipase A2-activating protein
PPARG peroxisome proliferator-activated receptor gamma
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RABGAP1L RAB GTPase activating protein 1-like
SAMD9 sterile alpha motif domain containing 9
SCN2B sodium channel, voltage gated, type II beta subunit
SDS serine dehydratase
SIPA1 signal-induced proliferation-associated 1
SIRPA signal-regulatory protein alpha
SOX2 SRY (sex determining region Y)-box 2
SP110 SP110 nuclear body protein
SPAG8 sperm associated antigen 8
SPG20 spastic paraplegia 20 (Troyer syndrome)
STAT1 signal transducer and activator of transcription 1, 91kDa
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TCP11L1 t-complex 11, testis-specific-like 1
TFF2 trefoil factor 2
TNNT3 troponin T type 3 (skeletal, fast)
TPMT thiopurine S-methyltransferase
TUBA3C tubulin, alpha 3c
USP2 ubiquitin specific peptidase 2
VIPR2 vasoactive intestinal peptide receptor 2
VPS9D1 VPS9 domain containing 1
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
XYLB xylulokinase homolog (H. influenzae)
ZBTB18 zinc finger and BTB domain containing 18
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADTRP androgen-dependent TFPI-regulating protein
ARPIN actin-related protein 2/3 complex inhibitor
ASIC3 acid sensing (proton gated) ion channel 3
ATAD5 ATPase family, AAA domain containing 5
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BAHCC1 BAH domain and coiled-coil containing 1
BIRC7 baculoviral IAP repeat containing 7
C16ORF45 chromosome 16 open reading frame 45
C17ORF80 chromosome 17 open reading frame 80
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMK1 calcium/calmodulin-dependent protein kinase I
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC9 coiled-coil domain containing 9
CD302 CD302 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CFD complement factor D (adipsin)
COPZ2 coatomer protein complex, subunit zeta 2
CRABP1 cellular retinoic acid binding protein 1
CSF1R colony stimulating factor 1 receptor
CXADR coxsackie virus and adenovirus receptor
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAL4 dynein, axonemal, light chain 4
DOC2A double C2-like domains, alpha
EDC4 enhancer of mRNA decapping 4
EVPL envoplakin
EXOC6B exocyst complex component 6B
EXTL2 exostosin-like glycosyltransferase 2
FGF23 fibroblast growth factor 23
FSD1 fibronectin type III and SPRY domain containing 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HDAC7 histone deacetylase 7
HIST1H4D histone cluster 1, H4d
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IL4R interleukin 4 receptor
INO80D INO80 complex subunit D
IQCG IQ motif containing G
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPKB inositol-trisphosphate 3-kinase B
KDM7A lysine (K)-specific demethylase 7A
KRT83 keratin 83, type II
LIF leukemia inhibitory factor
LOC390998 ribosomal protein L10 pseudogene
LTBP2 latent transforming growth factor beta binding protein 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCC mutated in colorectal cancers
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
NRSN2 neurensin 2
NT5DC3 5'-nucleotidase domain containing 3
ONECUT1 one cut homeobox 1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PADI1 peptidyl arginine deiminase, type I
PADI3 peptidyl arginine deiminase, type III
PARG poly (ADP-ribose) glycohydrolase
PCSK7 proprotein convertase subtilisin/kexin type 7
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLL polymerase (DNA directed), lambda
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRODH proline dehydrogenase (oxidase) 1
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RELN reelin
RHOBTB2 Rho-related BTB domain containing 2
S100A2 S100 calcium binding protein A2
SCD5 stearoyl-CoA desaturase 5
SDC3 syndecan 3
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SOX12 SRY (sex determining region Y)-box 12
SPRYD7 SPRY domain containing 7
SSPN sarcospan
SUN2 Sad1 and UNC84 domain containing 2
TAOK1 TAO kinase 1
TESC tescalcin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THRAP3 thyroid hormone receptor associated protein 3
TMC5 transmembrane channel-like 5
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TSPYL2 TSPY-like 2
UBQLN4 ubiquilin 4
USB1 U6 snRNA biogenesis 1
VN1R1 vomeronasal 1 receptor 1
XYLT2 xylosyltransferase II
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZCCHC6 zinc finger, CCHC domain containing 6
ZIC3 Zic family member 3
ZNF701 zinc finger protein 701