metoprolol-4508 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the metoprolol-4508 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACAN aggrecan
ACE2 angiotensin I converting enzyme 2
AMPD3 adenosine monophosphate deaminase 3
ANP32A-IT1 ANP32A intronic transcript 1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BMP4 bone morphogenetic protein 4
BTG2 BTG family, member 2
C1ORF95 chromosome 1 open reading frame 95
C22ORF46 chromosome 22 open reading frame 46
C4BPA complement component 4 binding protein, alpha
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC71 coiled-coil domain containing 71
CCP110 centriolar coiled coil protein 110kDa
CD68 CD68 molecule
CDK13 cyclin-dependent kinase 13
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEL carboxyl ester lipase
COL9A3 collagen, type IX, alpha 3
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CTBP2 C-terminal binding protein 2
CTNS cystinosin, lysosomal cystine transporter
CYTH4 cytohesin 4
DCN decorin
DOK5 docking protein 5
EFR3B EFR3 homolog B (S. cerevisiae)
ETNK2 ethanolamine kinase 2
FAM212B family with sequence similarity 212, member B
FAM49B family with sequence similarity 49, member B
FAM63B family with sequence similarity 63, member B
FBXO31 F-box protein 31
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FOXG1 forkhead box G1
FXYD7 FXYD domain containing ion transport regulator 7
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GLB1L galactosidase, beta 1-like
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR85 G protein-coupled receptor 85
GSTTP1 glutathione S-transferase theta pseudogene 1
ICOSLG inducible T-cell co-stimulator ligand
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IQCC IQ motif containing C
IRF9 interferon regulatory factor 9
JUND jun D proto-oncogene
KIAA0319L KIAA0319-like
KIAA1467 KIAA1467
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LIME1 Lck interacting transmembrane adaptor 1
LOC440895 two pore channel 3 pseudogene
LTBP4 latent transforming growth factor beta binding protein 4
MMP10 matrix metallopeptidase 10
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NCALD neurocalcin delta
NCAPH2 non-SMC condensin II complex, subunit H2
NPTX2 neuronal pentraxin II
NPTXR neuronal pentraxin receptor
NSUN6 NOP2/Sun domain family, member 6
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OASL 2'-5'-oligoadenylate synthetase-like
PDE4DIP phosphodiesterase 4D interacting protein
PMFBP1 polyamine modulated factor 1 binding protein 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKCE protein kinase C, epsilon
PROX1 prospero homeobox 1
RAB36 RAB36, member RAS oncogene family
RAD51B RAD51 paralog B
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RBPMS RNA binding protein with multiple splicing
REPS1 RALBP1 associated Eps domain containing 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPL10 ribosomal protein L10
RPL35A ribosomal protein L35a
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAMD9 sterile alpha motif domain containing 9
SCN3B sodium channel, voltage gated, type III beta subunit
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH3BP2 SH3-domain binding protein 2
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STRN4 striatin, calmodulin binding protein 4
SYN3 synapsin III
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TP53I11 tumor protein p53 inducible protein 11
TTC9 tetratricopeptide repeat domain 9
UBQLN4 ubiquilin 4
UBR2 ubiquitin protein ligase E3 component n-recognin 2
WIZ widely interspaced zinc finger motifs
WNT16 wingless-type MMTV integration site family, member 16
ZNF225 zinc finger protein 225
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BEX1 brain expressed, X-linked 1
C14ORF79 chromosome 14 open reading frame 79
C1S complement component 1, s subcomponent
C7ORF43 chromosome 7 open reading frame 43
CCNO cyclin O
CCNT1 cyclin T1
CD82 CD82 molecule
CDHR2 cadherin-related family member 2
CENPJ centromere protein J
CHM choroideremia (Rab escort protein 1)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLDN14 claudin 14
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNTN1 contactin 1
CRYGC crystallin, gamma C
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDN dendrin
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPHX2 epoxide hydrolase 2, cytoplasmic
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
EXOSC1 exosome component 1
FAM155A family with sequence similarity 155, member A
FBP1 fructose-1,6-bisphosphatase 1
FBXO2 F-box protein 2
FGL1 fibrinogen-like 1
FRMD1 FERM domain containing 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRTP1 growth hormone regulated TBC protein 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H3C histone cluster 1, H3c
HIST1H4C histone cluster 1, H4c
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMGB3P1 high mobility group box 3 pseudogene 1
HOXA7 homeobox A7
HOXC5 homeobox C5
HPN hepsin
IL33 interleukin 33
KLHL29 kelch-like family member 29
KRT31 keratin 31, type I
LDHC lactate dehydrogenase C
LOC100286895 cell division cycle 27 homolog pseudogene
LPPR1 lipid phosphate phosphatase-related protein type 1
LTC4S leukotriene C4 synthase
LY86 lymphocyte antigen 86
MDM4 MDM4, p53 regulator
MEGF8 multiple EGF-like-domains 8
MNX1 motor neuron and pancreas homeobox 1
MRPL44 mitochondrial ribosomal protein L44
MTA2 metastasis associated 1 family, member 2
MUC3B mucin 3B, cell surface associated
NPM3 nucleophosmin/nucleoplasmin 3
ONECUT2 one cut homeobox 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAIP2B poly(A) binding protein interacting protein 2B
PDE8B phosphodiesterase 8B
PID1 phosphotyrosine interaction domain containing 1
PLA2G1B phospholipase A2, group IB (pancreas)
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PODNL1 podocan-like 1
PPP1R17 protein phosphatase 1, regulatory subunit 17
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGFR prostaglandin F receptor (FP)
PTPRS protein tyrosine phosphatase, receptor type, S
RASA2 RAS p21 protein activator 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RNF126P1 ring finger protein 126 pseudogene 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SAA4 serum amyloid A4, constitutive
SAYSD1 SAYSVFN motif domain containing 1
SMR3A submaxillary gland androgen regulated protein 3A
STIM1 stromal interaction molecule 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D22B TBC1 domain family, member 22B
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEX15 testis expressed 15
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TM6SF1 transmembrane 6 superfamily member 1
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TUBA3C tubulin, alpha 3c
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WNT10B wingless-type MMTV integration site family, member 10B
WT1-AS WT1 antisense RNA
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF214 zinc finger protein 214
ZNF442 zinc finger protein 442
ZNF571 zinc finger protein 571
ZNF639 zinc finger protein 639