metolazone-6292 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the metolazone-6292 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADARB1 adenosine deaminase, RNA-specific, B1
AMDHD2 amidohydrolase domain containing 2
ATG10 autophagy related 10
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAHCC1 BAH domain and coiled-coil containing 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BMP5 bone morphogenetic protein 5
CALD1 caldesmon 1
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CD79B CD79b molecule, immunoglobulin-associated beta
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNR2 cannabinoid receptor 2 (macrophage)
COL7A1 collagen, type VII, alpha 1
COLEC10 collectin sub-family member 10 (C-type lectin)
COX4I1 cytochrome c oxidase subunit IV isoform 1
CROCC ciliary rootlet coiled-coil, rootletin
CSHL1 chorionic somatomammotropin hormone-like 1
CUZD1 CUB and zona pellucida-like domains 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DNAL4 dynein, axonemal, light chain 4
DTX2 deltex 2, E3 ubiquitin ligase
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ETNK2 ethanolamine kinase 2
FAM118A family with sequence similarity 118, member A
FBXO21 F-box protein 21
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GHRH growth hormone releasing hormone
GLS2 glutaminase 2 (liver, mitochondrial)
GRM1 glutamate receptor, metabotropic 1
HCFC1 host cell factor C1
HIC2 hypermethylated in cancer 2
HMGB3P1 high mobility group box 3 pseudogene 1
HOXB5 homeobox B5
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IL1RN interleukin 1 receptor antagonist
ITGB4 integrin, beta 4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
LGALS9 lectin, galactoside-binding, soluble, 9
LMNA lamin A/C
LOC257152 uncharacterized LOC257152
LRRC75B leucine rich repeat containing 75B
LY6D lymphocyte antigen 6 complex, locus D
MBNL2 muscleblind-like splicing regulator 2
MFAP3L microfibrillar-associated protein 3-like
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MYBPC3 myosin binding protein C, cardiac
MZF1 myeloid zinc finger 1
NCLN nicalin
NDRG4 NDRG family member 4
NEURL1 neuralized E3 ubiquitin protein ligase 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OTOR otoraplin
PDE11A phosphodiesterase 11A
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAC8 placenta-specific 8
PLCH1 phospholipase C, eta 1
PLXNA2 plexin A2
POMT2 protein-O-mannosyltransferase 2
PRICKLE3 prickle homolog 3 (Drosophila)
PRSS22 protease, serine, 22
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RARG retinoic acid receptor, gamma
RGS12 regulator of G-protein signaling 12
RPL10 ribosomal protein L10
RPP25 ribonuclease P/MRP 25kDa subunit
RUSC2 RUN and SH3 domain containing 2
SAFB2 scaffold attachment factor B2
SAMD4A sterile alpha motif domain containing 4A
SAMD9 sterile alpha motif domain containing 9
SCIN scinderin
SMYD5 SMYD family member 5
SPTBN1 spectrin, beta, non-erythrocytic 1
STAG3 stromal antigen 3
STX2 syntaxin 2
SUGP1 SURP and G patch domain containing 1
SYMPK symplekin
TECPR2 tectonin beta-propeller repeat containing 2
TG thyroglobulin
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TMSB15A thymosin beta 15a
TRIL TLR4 interactor with leucine-rich repeats
TSSK2 testis-specific serine kinase 2
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
VARS valyl-tRNA synthetase
WDR76 WD repeat domain 76
ZNF222 zinc finger protein 222
ZNF446 zinc finger protein 446

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG2 adhesion G protein-coupled receptor G2
AFAP1 actin filament associated protein 1
AP1AR adaptor-related protein complex 1 associated regulatory protein
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ATAD5 ATPase family, AAA domain containing 5
BAK1 BCL2-antagonist/killer 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
C17ORF70 chromosome 17 open reading frame 70
C1ORF56 chromosome 1 open reading frame 56
CCS copper chaperone for superoxide dismutase
CDC37L1 cell division cycle 37-like 1
CDC73 cell division cycle 73
CDIP1 cell death-inducing p53 target 1
CHMP6 charged multivesicular body protein 6
CIDEC cell death-inducing DFFA-like effector c
CRYBA2 crystallin, beta A2
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEPDC1 DEP domain containing 1
DLL3 delta-like 3 (Drosophila)
DPH2 DPH2 homolog (S. cerevisiae)
ELP3 elongator acetyltransferase complex subunit 3
ERCC2 excision repair cross-complementation group 2
FAM69A family with sequence similarity 69, member A
FER fer (fps/fes related) tyrosine kinase
FXN frataxin
FZD3 frizzled class receptor 3
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GHR growth hormone receptor
GNA13 guanine nucleotide binding protein (G protein), alpha 13
HOXA2 homeobox A2
HOXB9 homeobox B9
IGSF3 immunoglobulin superfamily, member 3
INCENP inner centromere protein antigens 135/155kDa
IRF1 interferon regulatory factor 1
IRF6 interferon regulatory factor 6
KIAA0513 KIAA0513
KIAA0753 KIAA0753
KLF2 Kruppel-like factor 2
LNPEP leucyl/cystinyl aminopeptidase
MECR mitochondrial trans-2-enoyl-CoA reductase
MOGS mannosyl-oligosaccharide glucosidase
MOXD1 monooxygenase, DBH-like 1
MUM1 melanoma associated antigen (mutated) 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NECAP2 NECAP endocytosis associated 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NPM3 nucleophosmin/nucleoplasmin 3
NR1H3 nuclear receptor subfamily 1, group H, member 3
PALMD palmdelphin
PC pyruvate carboxylase
PCDHGB5 protocadherin gamma subfamily B, 5
PCSK7 proprotein convertase subtilisin/kexin type 7
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PEX13 peroxisomal biogenesis factor 13
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLA2G15 phospholipase A2, group XV
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLEKHA6 pleckstrin homology domain containing, family A member 6
POM121 POM121 transmembrane nucleoporin
PRR3 proline rich 3
PSAT1 phosphoserine aminotransferase 1
PTCD2 pentatricopeptide repeat domain 2
RNF121 ring finger protein 121
RNF31 ring finger protein 31
RNFT1 ring finger protein, transmembrane 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SCAI suppressor of cancer cell invasion
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SH2D2A SH2 domain containing 2A
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SIPA1 signal-induced proliferation-associated 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein
SNIP1 Smad nuclear interacting protein 1
SOX12 SRY (sex determining region Y)-box 12
SPEG SPEG complex locus
STBD1 starch binding domain 1
STX4 syntaxin 4
SYTL2 synaptotagmin-like 2
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAOK1 TAO kinase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX40 testis expressed 40
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TPRA1 transmembrane protein, adipocyte asscociated 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM45 tripartite motif containing 45
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TSPAN15 tetraspanin 15
TSPAN8 tetraspanin 8
TTC33 tetratricopeptide repeat domain 33
ZNF107 zinc finger protein 107
ZNF197 zinc finger protein 197
ZNF253 zinc finger protein 253
ZNF408 zinc finger protein 408
ZNF816 zinc finger protein 816