metolazone-2014 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the metolazone-2014 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFF2 AF4/FMR2 family, member 2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ARFRP1 ADP-ribosylation factor related protein 1
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARRB2 arrestin, beta 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
AVPR1B arginine vasopressin receptor 1B
BCL7A B-cell CLL/lymphoma 7A
C4BPA complement component 4 binding protein, alpha
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBY1 chibby homolog 1 (Drosophila)
CD82 CD82 molecule
CDT1 chromatin licensing and DNA replication factor 1
CLCN6 chloride channel, voltage-sensitive 6
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DBP D site of albumin promoter (albumin D-box) binding protein
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM102A family with sequence similarity 102, member A
FAM153A family with sequence similarity 153, member A
FAM189A2 family with sequence similarity 189, member A2
FZD2 frizzled class receptor 2
GCKR glucokinase (hexokinase 4) regulator
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPR12 G protein-coupled receptor 12
GUCA2A guanylate cyclase activator 2A (guanylin)
HIST1H2AJ histone cluster 1, H2aj
HIST1H4J histone cluster 1, H4j
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-F major histocompatibility complex, class I, F
HP1BP3 heterochromatin protein 1, binding protein 3
HTRA2 HtrA serine peptidase 2
HYAL3 hyaluronoglucosaminidase 3
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IFNA17 interferon, alpha 17
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL1R2 interleukin 1 receptor, type II
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGA7 integrin, alpha 7
ITSN1 intersectin 1 (SH3 domain protein)
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDM5C lysine (K)-specific demethylase 5C
KLF6 Kruppel-like factor 6
KLHL18 kelch-like family member 18
LAMA4 laminin, alpha 4
LPAR2 lysophosphatidic acid receptor 2
LRRC14 leucine rich repeat containing 14
LTB4R leukotriene B4 receptor
MAGOH2P mago-nashi homolog 2, pseudogene
MAML3 mastermind-like 3 (Drosophila)
MAST3 microtubule associated serine/threonine kinase 3
METTL7A methyltransferase like 7A
MMP25 matrix metallopeptidase 25
MORC2 MORC family CW-type zinc finger 2
MSH3 mutS homolog 3
MSL3 male-specific lethal 3 homolog (Drosophila)
MST1 macrophage stimulating 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MZF1 myeloid zinc finger 1
NHEJ1 nonhomologous end-joining factor 1
PCIF1 PDX1 C-terminal inhibiting factor 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PICALM phosphatidylinositol binding clathrin assembly protein
PILRB paired immunoglobin-like type 2 receptor beta
PLCB4 phospholipase C, beta 4
POLG polymerase (DNA directed), gamma
PRLH prolactin releasing hormone
R3HDM1 R3H domain containing 1
RBFA ribosome binding factor A (putative)
RPL10 ribosomal protein L10
RTEL1 regulator of telomere elongation helicase 1
SARM1 sterile alpha and TIR motif containing 1
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SH2D3A SH2 domain containing 3A
SLC25A44 solute carrier family 25, member 44
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SPHK1 sphingosine kinase 1
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SRGN serglycin
ST7 suppression of tumorigenicity 7
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STRN4 striatin, calmodulin binding protein 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TARDBP TAR DNA binding protein
TCL1A T-cell leukemia/lymphoma 1A
TERT telomerase reverse transcriptase
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THEM6 thioesterase superfamily member 6
THOC6 THO complex 6
TUBGCP2 tubulin, gamma complex associated protein 2
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2O ubiquitin-conjugating enzyme E2O
VAC14 Vac14 homolog (S. cerevisiae)
XAF1 XIAP associated factor 1
ZFYVE26 zinc finger, FYVE domain containing 26
ZNF224 zinc finger protein 224
ZNF512B zinc finger protein 512B

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABHD4 abhydrolase domain containing 4
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ADAM9 ADAM metallopeptidase domain 9
ANKRD40 ankyrin repeat domain 40
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ASNSD1 asparagine synthetase domain containing 1
ATAD2B ATPase family, AAA domain containing 2B
ATF3 activating transcription factor 3
ATG7 autophagy related 7
ATXN2 ataxin 2
BCL10 B-cell CLL/lymphoma 10
BCL7C B-cell CLL/lymphoma 7C
BSG basigin (Ok blood group)
C1ORF216 chromosome 1 open reading frame 216
CASP8AP2 caspase 8 associated protein 2
CCDC53 coiled-coil domain containing 53
CDCA8 cell division cycle associated 8
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLDND1 claudin domain containing 1
CNR2 cannabinoid receptor 2 (macrophage)
CNTD2 cyclin N-terminal domain containing 2
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
COMMD10 COMM domain containing 10
COMMD3 COMM domain containing 3
COMMD8 COMM domain containing 8
CPOX coproporphyrinogen oxidase
CRIPT cysteine-rich PDZ-binding protein
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYCS cytochrome c, somatic
DDHD2 DDHD domain containing 2
DENND1A DENN/MADD domain containing 1A
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYNLL1 dynein, light chain, LC8-type 1
EGLN1 egl-9 family hypoxia-inducible factor 1
ERF Ets2 repressor factor
EXO1 exonuclease 1
FAF1 Fas (TNFRSF6) associated factor 1
FBXL4 F-box and leucine-rich repeat protein 4
FKBP3 FK506 binding protein 3, 25kDa
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GINS1 GINS complex subunit 1 (Psf1 homolog)
GMCL1 germ cell-less, spermatogenesis associated 1
GMEB1 glucocorticoid modulatory element binding protein 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HEBP1 heme binding protein 1
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HILPDA hypoxia inducible lipid droplet-associated
IL4R interleukin 4 receptor
INO80D INO80 complex subunit D
IP6K2 inositol hexakisphosphate kinase 2
ITGAV integrin, alpha V
KIAA0753 KIAA0753
KPNA4 karyopherin alpha 4 (importin alpha 3)
LIMA1 LIM domain and actin binding 1
MAPK3 mitogen-activated protein kinase 3
MAPKBP1 mitogen-activated protein kinase binding protein 1
METTL18 methyltransferase like 18
MOCS2 molybdenum cofactor synthesis 2
MRPL19 mitochondrial ribosomal protein L19
NDE1 nudE neurodevelopment protein 1
NDRG1 N-myc downstream regulated 1
PAQR3 progestin and adipoQ receptor family member III
PARG poly (ADP-ribose) glycohydrolase
PCTP phosphatidylcholine transfer protein
PEPD peptidase D
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PKN1 protein kinase N1
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RINT1 RAD50 interactor 1
RPUSD2 RNA pseudouridylate synthase domain containing 2
SERINC1 serine incorporator 1
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SMNDC1 survival motor neuron domain containing 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TBCC tubulin folding cofactor C
TBCCD1 TBCC domain containing 1
TK1 thymidine kinase 1, soluble
TMEM135 transmembrane protein 135
TMEM30A transmembrane protein 30A
TRAPPC11 trafficking protein particle complex 11
TRMT61B tRNA methyltransferase 61B
TSPAN32 tetraspanin 32
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USB1 U6 snRNA biogenesis 1
VLDLR very low density lipoprotein receptor
WDR18 WD repeat domain 18
ZCCHC8 zinc finger, CCHC domain containing 8
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF217 zinc finger protein 217
ZNF408 zinc finger protein 408