metolazone-1514 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the metolazone-1514 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ACSF2 acyl-CoA synthetase family member 2
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AIF1 allograft inflammatory factor 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANKRD12 ankyrin repeat domain 12
ANXA2P3 annexin A2 pseudogene 3
ARR3 arrestin 3, retinal (X-arrestin)
ASAP1-IT1 ASAP1 intronic transcript 1
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BIN1 bridging integrator 1
BMP5 bone morphogenetic protein 5
BTBD7 BTB (POZ) domain containing 7
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2ORF27A chromosome 2 open reading frame 27A
CDC25A cell division cycle 25A
CEP152 centrosomal protein 152kDa
CEP85 centrosomal protein 85kDa
CHRM3 cholinergic receptor, muscarinic 3
COL6A1 collagen, type VI, alpha 1
CRMP1 collapsin response mediator protein 1
CTNS cystinosin, lysosomal cystine transporter
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DLK2 delta-like 2 homolog (Drosophila)
EFNB3 ephrin-B3
EFR3B EFR3 homolog B (S. cerevisiae)
EPHB2 EPH receptor B2
ERC1 ELKS/RAB6-interacting/CAST family member 1
EXO5 exonuclease 5
EZR ezrin
FAM212B family with sequence similarity 212, member B
FAM214B family with sequence similarity 214, member B
FBXL8 F-box and leucine-rich repeat protein 8
FGF3 fibroblast growth factor 3
FKBP8 FK506 binding protein 8, 38kDa
FOXG1 forkhead box G1
GRIK5 glutamate receptor, ionotropic, kainate 5
HIST2H2AA3 histone cluster 2, H2aa3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXB3 homeobox B3
HOXC5 homeobox C5
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL6ST interleukin 6 signal transducer
KCNIP1 Kv channel interacting protein 1
KCTD17 potassium channel tetramerization domain containing 17
KIAA0319L KIAA0319-like
LAMC2 laminin, gamma 2
LEF1 lymphoid enhancer-binding factor 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAGOH2P mago-nashi homolog 2, pseudogene
MALL mal, T-cell differentiation protein-like
MED25 mediator complex subunit 25
MTA1 metastasis associated 1
MTERF1 mitochondrial transcription termination factor 1
MYO15B myosin XVB
NPY2R neuropeptide Y receptor Y2
NRSN2 neurensin 2
OGFR opioid growth factor receptor
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PCNX pecanex homolog (Drosophila)
PHC1 polyhomeotic homolog 1 (Drosophila)
PLK3 polo-like kinase 3
POMT2 protein-O-mannosyltransferase 2
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP5C protein phosphatase 5, catalytic subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RIMS3 regulating synaptic membrane exocytosis 3
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RNF17 ring finger protein 17
RUNDC3A RUN domain containing 3A
S100A8 S100 calcium binding protein A8
SAMD4A sterile alpha motif domain containing 4A
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STXBP5L syntaxin binding protein 5-like
SUMO1 small ubiquitin-like modifier 1
SYBU syntabulin (syntaxin-interacting)
SYNJ2 synaptojanin 2
TAOK2 TAO kinase 2
TH tyrosine hydroxylase
TIMELESS timeless circadian clock
TRD T cell receptor delta locus
TUBA3C tubulin, alpha 3c
TXNL4A thioredoxin-like 4A
USB1 U6 snRNA biogenesis 1
UTRN utrophin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIPR1 vasoactive intestinal peptide receptor 1
ZBTB14 zinc finger and BTB domain containing 14
ZDHHC14 zinc finger, DHHC-type containing 14
ZIC3 Zic family member 3
ZNF500 zinc finger protein 500
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AEN apoptosis enhancing nuclease
ALDOC aldolase C, fructose-bisphosphate
ALPK1 alpha-kinase 1
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARMC4 armadillo repeat containing 4
ARRB1 arrestin, beta 1
C8ORF60 chromosome 8 open reading frame 60
CAPRIN2 caprin family member 2
CBX7 chromobox homolog 7
CCDC121 coiled-coil domain containing 121
CCDC85C coiled-coil domain containing 85C
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDR2L cerebellar degeneration-related protein 2-like
CFD complement factor D (adipsin)
CIDEC cell death-inducing DFFA-like effector c
CLSPN claspin
CLSTN2 calsyntenin 2
CORO7 coronin 7
CORT cortistatin
CRYBG3 beta-gamma crystallin domain containing 3
CST6 cystatin E/M
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DGAT1 diacylglycerol O-acyltransferase 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DSCAM Down syndrome cell adhesion molecule
FBXL6 F-box and leucine-rich repeat protein 6
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GAMT guanidinoacetate N-methyltransferase
GRB7 growth factor receptor-bound protein 7
GRPR gastrin-releasing peptide receptor
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2AI histone cluster 1, H2ai
HIST1H2BJ histone cluster 1, H2bj
IPO8 importin 8
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA10 integrin, alpha 10
KIFC1 kinesin family member C1
KLHL26 kelch-like family member 26
KRT13 keratin 13, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LIME1 Lck interacting transmembrane adaptor 1
LOC257152 uncharacterized LOC257152
LOC390998 ribosomal protein L10 pseudogene
LRP2 low density lipoprotein receptor-related protein 2
LYPLA2P1 lysophospholipase II pseudogene 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MAST3 microtubule associated serine/threonine kinase 3
MBOAT2 membrane bound O-acyltransferase domain containing 2
MCOLN3 mucolipin 3
MKS1 Meckel syndrome, type 1
MMP2 matrix metallopeptidase 2
MSI1 musashi RNA-binding protein 1
MTRF1 mitochondrial translational release factor 1
MUC3A mucin 3A, cell surface associated
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NPFFR1 neuropeptide FF receptor 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5DC3 5'-nucleotidase domain containing 3
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PLEKHO2 pleckstrin homology domain containing, family O member 2
POM121 POM121 transmembrane nucleoporin
PYCRL pyrroline-5-carboxylate reductase-like
RAB30 RAB30, member RAS oncogene family
RANBP17 RAN binding protein 17
RGS19 regulator of G-protein signaling 19
RIN2 Ras and Rab interactor 2
RPAP2 RNA polymerase II associated protein 2
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUFY2 RUN and FYVE domain containing 2
S100A4 S100 calcium binding protein A4
SAYSD1 SAYSVFN motif domain containing 1
SDC3 syndecan 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC16A6 solute carrier family 16, member 6
SMA4 glucuronidase, beta pseudogene
SULT4A1 sulfotransferase family 4A, member 1
TADA2A transcriptional adaptor 2A
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TCTN2 tectonic family member 2
THBS3 thrombospondin 3
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TLR5 toll-like receptor 5
TMCC2 transmembrane and coiled-coil domain family 2
TMEM104 transmembrane protein 104
TMEM184C transmembrane protein 184C
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM25 tripartite motif containing 25
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSPAN5 tetraspanin 5
UBQLN4 ubiquilin 4
UNC93B1 unc-93 homolog B1 (C. elegans)
VASH1 vasohibin 1
WDR25 WD repeat domain 25
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZNF276 zinc finger protein 276
ZNF492 zinc finger protein 492