metoclopramide-4750 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the metoclopramide-4750 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ADAM22 ADAM metallopeptidase domain 22
ADORA1 adenosine A1 receptor
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANKRD7 ankyrin repeat domain 7
ASIC1 acid sensing (proton gated) ion channel 1
BCL6 B-cell CLL/lymphoma 6
BST2 bone marrow stromal cell antigen 2
BUD31 BUD31 homolog (S. cerevisiae)
C1ORF54 chromosome 1 open reading frame 54
C7ORF69 chromosome 7 open reading frame 69
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCDC64 coiled-coil domain containing 64
CCR2 chemokine (C-C motif) receptor 2
CD300A CD300a molecule
CDH8 cadherin 8, type 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEP135 centrosomal protein 135kDa
CIDEB cell death-inducing DFFA-like effector b
CLUL1 clusterin-like 1 (retinal)
CNTN5 contactin 5
CPQ carboxypeptidase Q
CRYGC crystallin, gamma C
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DNAAF1 dynein, axonemal, assembly factor 1
DST dystonin
DTNB dystrobrevin, beta
FCGBP Fc fragment of IgG binding protein
GLB1L galactosidase, beta 1-like
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPM6B glycoprotein M6B
GPR75 G protein-coupled receptor 75
GSTA1 glutathione S-transferase alpha 1
HOXB2 homeobox B2
HPR haptoglobin-related protein
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
ICOS inducible T-cell co-stimulator
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHM immunoglobulin heavy constant mu
IGSF6 immunoglobulin superfamily, member 6
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KIF21B kinesin family member 21B
KLHL35 kelch-like family member 35
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEB4 melanoma antigen family B4
MALL mal, T-cell differentiation protein-like
MAPK7 mitogen-activated protein kinase 7
MED25 mediator complex subunit 25
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
MYT1 myelin transcription factor 1
NAG18 NAG18 mRNA
NRF1 nuclear respiratory factor 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAX3 paired box 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCLO piccolo presynaptic cytomatrix protein
PLCH1 phospholipase C, eta 1
PLTP phospholipid transfer protein
POM121L2 POM121 transmembrane nucleoporin-like 2
PRDM2 PR domain containing 2, with ZNF domain
PRKCA protein kinase C, alpha
PTGIS prostaglandin I2 (prostacyclin) synthase
PTHLH parathyroid hormone-like hormone
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAB40C RAB40C, member RAS oncogene family
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RB1 retinoblastoma 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBP4 retinol binding protein 4, plasma
RNASE4 ribonuclease, RNase A family, 4
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RUNX1 runt-related transcription factor 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEZ6L seizure related 6 homolog (mouse)-like
SH3D21 SH3 domain containing 21
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPG20 spastic paraplegia 20 (Troyer syndrome)
SRSF7 serine/arginine-rich splicing factor 7
TBC1D2 TBC1 domain family, member 2
TBL2 transducin (beta)-like 2
TCP10 t-complex 10
THOC5 THO complex 5
TMPRSS4 transmembrane protease, serine 4
TP63 tumor protein p63
TUBA3C tubulin, alpha 3c
VGLL3 vestigial-like family member 3
WSB1 WD repeat and SOCS box containing 1
YY2 YY2 transcription factor
ZC3H7B zinc finger CCCH-type containing 7B

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BGLAP bone gamma-carboxyglutamate (gla) protein
C19ORF73 chromosome 19 open reading frame 73
C1ORF105 chromosome 1 open reading frame 105
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2ORF27A chromosome 2 open reading frame 27A
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CBX7 chromobox homolog 7
CCDC68 coiled-coil domain containing 68
CCRL2 chemokine (C-C motif) receptor-like 2
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDADC1 cytidine and dCMP deaminase domain containing 1
CDKN2AIP CDKN2A interacting protein
CEL carboxyl ester lipase
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CHST10 carbohydrate sulfotransferase 10
CLDN1 claudin 1
CLGN calmegin
CLSTN2 calsyntenin 2
CORO7 coronin 7
DGKE diacylglycerol kinase, epsilon 64kDa
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DRD1 dopamine receptor D1
EFNA3 ephrin-A3
EGFL7 EGF-like-domain, multiple 7
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM120C family with sequence similarity 120C
FGL1 fibrinogen-like 1
GBP2 guanylate binding protein 2, interferon-inducible
GDAP1 ganglioside induced differentiation associated protein 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPATCH2L G patch domain containing 2-like
GTPBP2 GTP binding protein 2
HIST1H4F histone cluster 1, H4f
HOXC10 homeobox C10
HYI hydroxypyruvate isomerase (putative)
IQSEC2 IQ motif and Sec7 domain 2
KIAA0894 KIAA0894 protein
LOC390998 ribosomal protein L10 pseudogene
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCOLN3 mucolipin 3
MMRN2 multimerin 2
MRPS18C mitochondrial ribosomal protein S18C
MTCP1 mature T-cell proliferation 1
MXD3 MAX dimerization protein 3
NCALD neurocalcin delta
NHEJ1 nonhomologous end-joining factor 1
NNAT neuronatin
ONECUT1 one cut homeobox 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OVGP1 oviductal glycoprotein 1, 120kDa
PARD6B par-6 family cell polarity regulator beta
PCDHB8 protocadherin beta 8
PER3 period circadian clock 3
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PGR progesterone receptor
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RAB36 RAB36, member RAS oncogene family
RAI2 retinoic acid induced 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REM1 RAS (RAD and GEM)-like GTP-binding 1
RLN2 relaxin 2
RPA4 replication protein A4, 30kDa
S100A2 S100 calcium binding protein A2
SAYSD1 SAYSVFN motif domain containing 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERGEF secretion regulating guanine nucleotide exchange factor
SKI SKI proto-oncogene
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TAOK1 TAO kinase 1
TBX19 T-box 19
TBX3 T-box 3
TIGD6 tigger transposable element derived 6
TMC7 transmembrane channel-like 7
TMEM242 transmembrane protein 242
TRPM4 transient receptor potential cation channel, subfamily M, member 4
UBXN6 UBX domain protein 6
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBTB38 zinc finger and BTB domain containing 38
ZNF205 zinc finger protein 205
ZNF219 zinc finger protein 219
ZNF329 zinc finger protein 329
ZNF711 zinc finger protein 711