methylergometrine-6704 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the methylergometrine-6704 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADGB androglobin
AIM2 absent in melanoma 2
APC2 adenomatosis polyposis coli 2
ARHGAP44 Rho GTPase activating protein 44
ASPA aspartoacylase
ATXN3L ataxin 3-like
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C10ORF12 chromosome 10 open reading frame 12
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CISH cytokine inducible SH2-containing protein
COL1A2 collagen, type I, alpha 2
CORO7 coronin 7
CPN2 carboxypeptidase N, polypeptide 2
CRYGD crystallin, gamma D
CSF1 colony stimulating factor 1 (macrophage)
CST1 cystatin SN
CTSF cathepsin F
CUL3 cullin 3
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DEFA4 defensin, alpha 4, corticostatin
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EGOT eosinophil granule ontogeny transcript (non-protein coding)
ELL elongation factor RNA polymerase II
EXO5 exonuclease 5
FAM205BP transmembrane protein C9orf144B pseudogene
FBXO21 F-box protein 21
FER1L4 fer-1-like family member 4, pseudogene (functional)
FOXL1 forkhead box L1
GAN gigaxonin
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM2 glutamate receptor, metabotropic 2
GYPB glycophorin B (MNS blood group)
HEMK1 HemK methyltransferase family member 1
HFE hemochromatosis
HOXC4 homeobox C4
HYAL1 hyaluronoglucosaminidase 1
ICOS inducible T-cell co-stimulator
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KRT12 keratin 12, type I
LINC00216 long intergenic non-protein coding RNA 216
LOXL2 lysyl oxidase-like 2
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MCTP2 multiple C2 domains, transmembrane 2
MED25 mediator complex subunit 25
MED27 mediator complex subunit 27
MEG3 maternally expressed 3 (non-protein coding)
NDOR1 NADPH dependent diflavin oxidoreductase 1
NEK3 NIMA-related kinase 3
NIPAL2 NIPA-like domain containing 2
NOX3 NADPH oxidase 3
NRF1 nuclear respiratory factor 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PARP11 poly (ADP-ribose) polymerase family, member 11
PAWR PRKC, apoptosis, WT1, regulator
PBOV1 prostate and breast cancer overexpressed 1
PDE4DIP phosphodiesterase 4D interacting protein
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLAC4 placenta-specific 4
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRDM12 PR domain containing 12
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROL1 proline rich, lacrimal 1
PTCRA pre T-cell antigen receptor alpha
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RGS12 regulator of G-protein signaling 12
RIMS1 regulating synaptic membrane exocytosis 1
RNLS renalase, FAD-dependent amine oxidase
RPL14 ribosomal protein L14
RS1 retinoschisin 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLN sarcolipin
SMAD1 SMAD family member 1
SPO11 SPO11 meiotic protein covalently bound to DSB
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRPX2 sushi-repeat containing protein, X-linked 2
SVIL supervillin
TBX5 T-box 5
TIMELESS timeless circadian clock
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLX2 T-cell leukemia homeobox 2
TM4SF5 transmembrane 4 L six family member 5
TMEM246 transmembrane protein 246
TMPRSS4 transmembrane protease, serine 4
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRAC T cell receptor alpha constant
TRPM3 transient receptor potential cation channel, subfamily M, member 3
VWA5A von Willebrand factor A domain containing 5A
ZNF234 zinc finger protein 234
ZNF268 zinc finger protein 268
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
ADGRG6 adhesion G protein-coupled receptor G6
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALS2CL ALS2 C-terminal like
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BAHD1 bromo adjacent homology domain containing 1
BEX4 brain expressed, X-linked 4
BTF3P12 basic transcription factor 3 pseudogene 12
CA5BP1 carbonic anhydrase VB pseudogene 1
CCP110 centriolar coiled coil protein 110kDa
CDT1 chromatin licensing and DNA replication factor 1
CHM choroideremia (Rab escort protein 1)
CLDND1 claudin domain containing 1
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CTSD cathepsin D
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCAF13 DDB1 and CUL4 associated factor 13
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DMTN dematin actin binding protein
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EML4 echinoderm microtubule associated protein like 4
EMP3 epithelial membrane protein 3
ERAP2 endoplasmic reticulum aminopeptidase 2
ERMP1 endoplasmic reticulum metallopeptidase 1
EXOC5 exocyst complex component 5
EXOSC5 exosome component 5
FAM50B family with sequence similarity 50, member B
FANCC Fanconi anemia, complementation group C
FAT4 FAT atypical cadherin 4
FBXW12 F-box and WD repeat domain containing 12
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FNTB farnesyltransferase, CAAX box, beta
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GJC1 gap junction protein, gamma 1, 45kDa
GPR176 G protein-coupled receptor 176
HIST1H2AM histone cluster 1, H2am
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IREB2 iron-responsive element binding protein 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD7 potassium channel tetramerization domain containing 7
KDM7A lysine (K)-specific demethylase 7A
KIRREL kin of IRRE like (Drosophila)
LIG4 ligase IV, DNA, ATP-dependent
LMAN1 lectin, mannose-binding, 1
LRRC61 leucine rich repeat containing 61
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MCOLN1 mucolipin 1
MMP13 matrix metallopeptidase 13
MON1B MON1 secretory trafficking family member B
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MYL9 myosin, light chain 9, regulatory
NAT6 N-acetyltransferase 6 (GCN5-related)
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
OCLN occludin
PAX9 paired box 9
PDE12 phosphodiesterase 12
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PLCD1 phospholipase C, delta 1
PLD3 phospholipase D family, member 3
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PWAR5 Prader Willi/Angelman region RNA 5
RAB17 RAB17, member RAS oncogene family
RAI2 retinoic acid induced 2
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNF146 ring finger protein 146
RUNX1-IT1 RUNX1 intronic transcript 1
S100A3 S100 calcium binding protein A3
SCN10A sodium channel, voltage gated, type X alpha subunit
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SPAG7 sperm associated antigen 7
STK16 serine/threonine kinase 16
SUGP1 SURP and G patch domain containing 1
TBC1D17 TBC1 domain family, member 17
THRAP3 thyroid hormone receptor associated protein 3
TMEM132A transmembrane protein 132A
TMEM212 transmembrane protein 212
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRABD TraB domain containing
TRIM25 tripartite motif containing 25
TSKU tsukushi, small leucine rich proteoglycan
TWISTNB TWIST neighbor
USP32 ubiquitin specific peptidase 32
WDR25 WD repeat domain 25
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF227 zinc finger protein 227
ZNF532 zinc finger protein 532
ZNF667 zinc finger protein 667