methylergometrine-6704 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the methylergometrine-6704 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADGB androglobin
AIM2 absent in melanoma 2
APC2 adenomatosis polyposis coli 2
ARHGAP44 Rho GTPase activating protein 44
ASPA aspartoacylase
ATXN3L ataxin 3-like
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C10ORF12 chromosome 10 open reading frame 12
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CISH cytokine inducible SH2-containing protein
COL1A2 collagen, type I, alpha 2
CORO7 coronin 7
CPN2 carboxypeptidase N, polypeptide 2
CRYGD crystallin, gamma D
CSF1 colony stimulating factor 1 (macrophage)
CST1 cystatin SN
CTSF cathepsin F
CUL3 cullin 3
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DEFA4 defensin, alpha 4, corticostatin
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EGOT eosinophil granule ontogeny transcript (non-protein coding)
ELL elongation factor RNA polymerase II
EXO5 exonuclease 5
FAM205BP transmembrane protein C9orf144B pseudogene
FBXO21 F-box protein 21
FER1L4 fer-1-like family member 4, pseudogene (functional)
FOXL1 forkhead box L1
GAN gigaxonin
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM2 glutamate receptor, metabotropic 2
GYPB glycophorin B (MNS blood group)
HEMK1 HemK methyltransferase family member 1
HFE hemochromatosis
HOXC4 homeobox C4
HYAL1 hyaluronoglucosaminidase 1
ICOS inducible T-cell co-stimulator
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KRT12 keratin 12, type I
LINC00216 long intergenic non-protein coding RNA 216
LOXL2 lysyl oxidase-like 2
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MCTP2 multiple C2 domains, transmembrane 2
MED25 mediator complex subunit 25
MED27 mediator complex subunit 27
MEG3 maternally expressed 3 (non-protein coding)
NDOR1 NADPH dependent diflavin oxidoreductase 1
NEK3 NIMA-related kinase 3
NIPAL2 NIPA-like domain containing 2
NOX3 NADPH oxidase 3
NRF1 nuclear respiratory factor 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PARP11 poly (ADP-ribose) polymerase family, member 11
PAWR PRKC, apoptosis, WT1, regulator
PBOV1 prostate and breast cancer overexpressed 1
PDE4DIP phosphodiesterase 4D interacting protein
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLAC4 placenta-specific 4
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRDM12 PR domain containing 12
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROL1 proline rich, lacrimal 1
PTCRA pre T-cell antigen receptor alpha
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RGS12 regulator of G-protein signaling 12
RIMS1 regulating synaptic membrane exocytosis 1
RNLS renalase, FAD-dependent amine oxidase
RPL14 ribosomal protein L14
RS1 retinoschisin 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLN sarcolipin
SMAD1 SMAD family member 1
SPO11 SPO11 meiotic protein covalently bound to DSB
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRPX2 sushi-repeat containing protein, X-linked 2
SVIL supervillin
TBX5 T-box 5
TIMELESS timeless circadian clock
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLX2 T-cell leukemia homeobox 2
TM4SF5 transmembrane 4 L six family member 5
TMEM246 transmembrane protein 246
TMPRSS4 transmembrane protease, serine 4
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRAC T cell receptor alpha constant
TRPM3 transient receptor potential cation channel, subfamily M, member 3
VWA5A von Willebrand factor A domain containing 5A
ZNF234 zinc finger protein 234
ZNF268 zinc finger protein 268
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
ADGRG6 adhesion G protein-coupled receptor G6
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALS2CL ALS2 C-terminal like
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BAHD1 bromo adjacent homology domain containing 1
BEX4 brain expressed, X-linked 4
BTF3P12 basic transcription factor 3 pseudogene 12
CA5BP1 carbonic anhydrase VB pseudogene 1
CCP110 centriolar coiled coil protein 110kDa
CDT1 chromatin licensing and DNA replication factor 1
CHM choroideremia (Rab escort protein 1)
CLDND1 claudin domain containing 1
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CTSD cathepsin D
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCAF13 DDB1 and CUL4 associated factor 13
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DMTN dematin actin binding protein
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EML4 echinoderm microtubule associated protein like 4
EMP3 epithelial membrane protein 3
ERAP2 endoplasmic reticulum aminopeptidase 2
ERMP1 endoplasmic reticulum metallopeptidase 1
EXOC5 exocyst complex component 5
EXOSC5 exosome component 5
FAM50B family with sequence similarity 50, member B
FANCC Fanconi anemia, complementation group C
FAT4 FAT atypical cadherin 4
FBXW12 F-box and WD repeat domain containing 12
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FNTB farnesyltransferase, CAAX box, beta
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GJC1 gap junction protein, gamma 1, 45kDa
GPR176 G protein-coupled receptor 176
HIST1H2AM histone cluster 1, H2am
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IREB2 iron-responsive element binding protein 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD7 potassium channel tetramerization domain containing 7
KDM7A lysine (K)-specific demethylase 7A
KIRREL kin of IRRE like (Drosophila)
LIG4 ligase IV, DNA, ATP-dependent
LMAN1 lectin, mannose-binding, 1
LRRC61 leucine rich repeat containing 61
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MCOLN1 mucolipin 1
MMP13 matrix metallopeptidase 13
MON1B MON1 secretory trafficking family member B
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MYL9 myosin, light chain 9, regulatory
NAT6 N-acetyltransferase 6 (GCN5-related)
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
OCLN occludin
PAX9 paired box 9
PDE12 phosphodiesterase 12
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PLCD1 phospholipase C, delta 1
PLD3 phospholipase D family, member 3
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PWAR5 Prader Willi/Angelman region RNA 5
RAB17 RAB17, member RAS oncogene family
RAI2 retinoic acid induced 2
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNF146 ring finger protein 146
RUNX1-IT1 RUNX1 intronic transcript 1
S100A3 S100 calcium binding protein A3
SCN10A sodium channel, voltage gated, type X alpha subunit
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SPAG7 sperm associated antigen 7
STK16 serine/threonine kinase 16
SUGP1 SURP and G patch domain containing 1
TBC1D17 TBC1 domain family, member 17
THRAP3 thyroid hormone receptor associated protein 3
TMEM132A transmembrane protein 132A
TMEM212 transmembrane protein 212
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRABD TraB domain containing
TRIM25 tripartite motif containing 25
TSKU tsukushi, small leucine rich proteoglycan
USP32 ubiquitin specific peptidase 32
WDR25 WD repeat domain 25
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF227 zinc finger protein 227
ZNF532 zinc finger protein 532
ZNF667 zinc finger protein 667