methyldopate-7360 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the methyldopate-7360 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACTG2 actin, gamma 2, smooth muscle, enteric
ALS2CL ALS2 C-terminal like
ANGEL2 angel homolog 2 (Drosophila)
ARHGAP33 Rho GTPase activating protein 33
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATG2A autophagy related 2A
BCAM basal cell adhesion molecule (Lutheran blood group)
C2ORF27A chromosome 2 open reading frame 27A
C9ORF9 chromosome 9 open reading frame 9
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCP110 centriolar coiled coil protein 110kDa
CD6 CD6 molecule
CIDEB cell death-inducing DFFA-like effector b
CLCN5 chloride channel, voltage-sensitive 5
CLCN7 chloride channel, voltage-sensitive 7
CLEC11A C-type lectin domain family 11, member A
CORO7 coronin 7
COX4I1 cytochrome c oxidase subunit IV isoform 1
DCTN1 dynactin 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSC3 desmocollin 3
DSCAM Down syndrome cell adhesion molecule
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELOVL5 ELOVL fatty acid elongase 5
ERAP1 endoplasmic reticulum aminopeptidase 1
FADS2 fatty acid desaturase 2
FAM120C family with sequence similarity 120C
FAM149B1 family with sequence similarity 149, member B1
FAM46C family with sequence similarity 46, member C
FGF2 fibroblast growth factor 2 (basic)
FLJ21369 uncharacterized protein FLJ21369
FLT3LG fms-related tyrosine kinase 3 ligand
FOXI1 forkhead box I1
FRK fyn-related Src family tyrosine kinase
GH1 growth hormone 1
GOLGA2 golgin A2
GPR107 G protein-coupled receptor 107
HBS1L HBS1-like translational GTPase
HFE hemochromatosis
HIPK2 homeodomain interacting protein kinase 2
HMGA1 high mobility group AT-hook 1
HOMER3 homer scaffolding protein 3
IL1RN interleukin 1 receptor antagonist
ITGB4 integrin, beta 4
JADE2 jade family PHD finger 2
KALRN kalirin, RhoGEF kinase
LPAR4 lysophosphatidic acid receptor 4
MAP1A microtubule-associated protein 1A
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAP4 microtubule-associated protein 4
MARK4 MAP/microtubule affinity-regulating kinase 4
MED16 mediator complex subunit 16
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MYOF myoferlin
NAG18 NAG18 mRNA
NCKIPSD NCK interacting protein with SH3 domain
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NME5 NME/NM23 family member 5
PARD6A par-6 family cell polarity regulator alpha
PCSK6 proprotein convertase subtilisin/kexin type 6
PHF3 PHD finger protein 3
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPARD peroxisome proliferator-activated receptor delta
PRDX2 peroxiredoxin 2
PRSS53 protease, serine, 53
PTPRS protein tyrosine phosphatase, receptor type, S
RAB11B RAB11B, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RECQL5 RecQ protein-like 5
RGS12 regulator of G-protein signaling 12
RPS2 ribosomal protein S2
S100A9 S100 calcium binding protein A9
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH3BP2 SH3-domain binding protein 2
SHOX2 short stature homeobox 2
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SPRR1A small proline-rich protein 1A
SSPN sarcospan
STMN1 stathmin 1
TFPI2 tissue factor pathway inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNK1 tyrosine kinase, non-receptor, 1
TRIM3 tripartite motif containing 3
TTLL3 tubulin tyrosine ligase-like family member 3
UBE2I ubiquitin-conjugating enzyme E2I
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VN1R1 vomeronasal 1 receptor 1
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF37BP zinc finger protein 37B, pseudogene
ZNF442 zinc finger protein 442
ZNF747 zinc finger protein 747
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATXN2 ataxin 2
BAHCC1 BAH domain and coiled-coil containing 1
C7ORF43 chromosome 7 open reading frame 43
C9ORF91 chromosome 9 open reading frame 91
CCDC186 coiled-coil domain containing 186
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD82 CD82 molecule
CDKL3 cyclin-dependent kinase-like 3
CLCF1 cardiotrophin-like cytokine factor 1
CLSTN2 calsyntenin 2
COL9A2 collagen, type IX, alpha 2
COMMD10 COMM domain containing 10
CPED1 cadherin-like and PC-esterase domain containing 1
CST6 cystatin E/M
CXORF56 chromosome X open reading frame 56
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DUSP13 dual specificity phosphatase 13
DVL1 dishevelled segment polarity protein 1
DYSF dysferlin
EFNA3 ephrin-A3
ELOVL4 ELOVL fatty acid elongase 4
EMID1 EMI domain containing 1
FAM50B family with sequence similarity 50, member B
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FRMPD1 FERM and PDZ domain containing 1
GBP2 guanylate binding protein 2, interferon-inducible
GLB1L2 galactosidase, beta 1-like 2
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPATCH2L G patch domain containing 2-like
GRTP1 growth hormone regulated TBC protein 1
GSTCD glutathione S-transferase, C-terminal domain containing
GSTT1 glutathione S-transferase theta 1
HAND1 heart and neural crest derivatives expressed 1
HDAC4 histone deacetylase 4
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BF histone cluster 1, H2bf
HIST1H2BI histone cluster 1, H2bi
HIST1H4A histone cluster 1, H4a
HIST1H4D histone cluster 1, H4d
HOXC10 homeobox C10
IDI2-AS1 IDI2 antisense RNA 1
IFI6 interferon, alpha-inducible protein 6
IPO8 importin 8
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIAA0754 KIAA0754
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL25 kelch-like family member 25
LAMB3 laminin, beta 3
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC49 leucine rich repeat containing 49
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEK11 NIMA-related kinase 11
NPR3 natriuretic peptide receptor 3
PELI1 pellino E3 ubiquitin protein ligase 1
PGPEP1 pyroglutamyl-peptidase I
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLTP phospholipid transfer protein
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
POM121 POM121 transmembrane nucleoporin
PROCR protein C receptor, endothelial
PYCRL pyrroline-5-carboxylate reductase-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB3A RAB3A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPH3AL rabphilin 3A-like (without C2 domains)
RPL7A ribosomal protein L7a
SCHIP1 schwannomin interacting protein 1
SLC12A9 solute carrier family 12, member 9
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SPAG4 sperm associated antigen 4
SYCP2 synaptonemal complex protein 2
TESK1 testis-specific kinase 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM209 transmembrane protein 209
TMEM51 transmembrane protein 51
TRAIP TRAF interacting protein
TRIM25 tripartite motif containing 25
TTPAL tocopherol (alpha) transfer protein-like
TUBGCP5 tubulin, gamma complex associated protein 5
UBOX5 U-box domain containing 5
VASH1 vasohibin 1
VAV1 vav 1 guanine nucleotide exchange factor
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR4 WD repeat domain 4
WDR62 WD repeat domain 62
WDR76 WD repeat domain 76
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFP30 ZFP30 zinc finger protein
ZNF205 zinc finger protein 205
ZNF41 zinc finger protein 41
ZNF506 zinc finger protein 506
ZNF552 zinc finger protein 552