methyldopate-2940 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the methyldopate-2940 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIF1 allograft inflammatory factor 1
ARHGAP44 Rho GTPase activating protein 44
ATXN2L ataxin 2-like
AXIN1 axin 1
BCL2 B-cell CLL/lymphoma 2
BMP6 bone morphogenetic protein 6
BTBD7 BTB (POZ) domain containing 7
C11ORF16 chromosome 11 open reading frame 16
C9ORF9 chromosome 9 open reading frame 9
CDON cell adhesion associated, oncogene regulated
CLCN7 chloride channel, voltage-sensitive 7
CNTD2 cyclin N-terminal domain containing 2
CNTN1 contactin 1
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL5A2 collagen, type V, alpha 2
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DMP1 dentin matrix acidic phosphoprotein 1
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DRD2 dopamine receptor D2
ELN elastin
ELSPBP1 epididymal sperm binding protein 1
EPHB3 EPH receptor B3
F12 coagulation factor XII (Hageman factor)
FER1L4 fer-1-like family member 4, pseudogene (functional)
FTCD formimidoyltransferase cyclodeaminase
GIPC1 GIPC PDZ domain containing family, member 1
GLP1R glucagon-like peptide 1 receptor
GMPR guanosine monophosphate reductase
GRM1 glutamate receptor, metabotropic 1
GSTA3 glutathione S-transferase alpha 3
HAB1 B1 for mucin
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HEXIM1 hexamethylene bis-acetamide inducible 1
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGHM immunoglobulin heavy constant mu
ING2 inhibitor of growth family, member 2
JMJD4 jumonji domain containing 4
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
LMNA lamin A/C
MVD mevalonate (diphospho) decarboxylase
MYO6 myosin VI
MYOF myoferlin
NCS1 neuronal calcium sensor 1
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRP1 NLR family, pyrin domain containing 1
NOP16 NOP16 nucleolar protein
NPFFR1 neuropeptide FF receptor 1
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NRAP nebulin-related anchoring protein
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE8B phosphodiesterase 8B
PGP phosphoglycolate phosphatase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKLR pyruvate kinase, liver and RBC
PLXNB2 plexin B2
PML promyelocytic leukemia
PRDM1 PR domain containing 1, with ZNF domain
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPCTL glutaminyl-peptide cyclotransferase-like
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBP4 retinol binding protein 4, plasma
RPL7 ribosomal protein L7
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCAMP5 secretory carrier membrane protein 5
SEC14L5 SEC14-like 5 (S. cerevisiae)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SETD1A SET domain containing 1A
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOCS1 suppressor of cytokine signaling 1
SOCS7 suppressor of cytokine signaling 7
SORBS1 sorbin and SH3 domain containing 1
TCP1 t-complex 1
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM187 transmembrane protein 187
TMPRSS15 transmembrane protease, serine 15
TP53TG5 TP53 target 5
TPD52L1 tumor protein D52-like 1
TREM2 triggering receptor expressed on myeloid cells 2
TRIM3 tripartite motif containing 3
TTLL5 tubulin tyrosine ligase-like family member 5
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
WWOX WW domain containing oxidoreductase
ZNF407 zinc finger protein 407
ZNF460 zinc finger protein 460
ZNF580 zinc finger protein 580

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AGBL5 ATP/GTP binding protein-like 5
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARL15 ADP-ribosylation factor-like 15
ARMC7 armadillo repeat containing 7
ASGR2 asialoglycoprotein receptor 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BBS7 Bardet-Biedl syndrome 7
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
C17ORF80 chromosome 17 open reading frame 80
C6ORF47 chromosome 6 open reading frame 47
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CEP70 centrosomal protein 70kDa
CORO7 coronin 7
CPSF3L cleavage and polyadenylation specific factor 3-like
CPTP ceramide-1-phosphate transfer protein
CRELD2 cysteine-rich with EGF-like domains 2
CRNKL1 crooked neck pre-mRNA splicing factor 1
CXCR2 chemokine (C-X-C motif) receptor 2
DCAF17 DDB1 and CUL4 associated factor 17
DDA1 DET1 and DDB1 associated 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DTX4 deltex 4, E3 ubiquitin ligase
EGR2 early growth response 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM188A family with sequence similarity 188, member A
GALE UDP-galactose-4-epimerase
GID4 GID complex subunit 4
GMCL1 germ cell-less, spermatogenesis associated 1
GMIP GEM interacting protein
GPATCH2 G patch domain containing 2
GPR65 G protein-coupled receptor 65
HIST1H2BJ histone cluster 1, H2bj
HPSE heparanase
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IP6K1 inositol hexakisphosphate kinase 1
KDM7A lysine (K)-specific demethylase 7A
KIF24 kinesin family member 24
KLF13 Kruppel-like factor 13
KPTN kaptin (actin binding protein)
LGALS9 lectin, galactoside-binding, soluble, 9
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LINC00115 long intergenic non-protein coding RNA 115
LINC00597 long intergenic non-protein coding RNA 597
LOC157562 uncharacterized LOC157562
LPAR6 lysophosphatidic acid receptor 6
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
MAGEB2 melanoma antigen family B2
MAK male germ cell-associated kinase
MANEA mannosidase, endo-alpha
MAP1S microtubule-associated protein 1S
MCOLN1 mucolipin 1
METTL16 methyltransferase like 16
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MIR22HG MIR22 host gene
MOCOS molybdenum cofactor sulfurase
NTSR1 neurotensin receptor 1 (high affinity)
PAQR6 progestin and adipoQ receptor family member VI
PARG poly (ADP-ribose) glycohydrolase
PCNXL4 pecanex-like 4 (Drosophila)
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
POLM polymerase (DNA directed), mu
PYGB phosphorylase, glycogen; brain
QTRT1 queuine tRNA-ribosyltransferase 1
RABL3 RAB, member of RAS oncogene family-like 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF126P1 ring finger protein 126 pseudogene 1
RWDD2A RWD domain containing 2A
SECISBP2 SECIS binding protein 2
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLFN12 schlafen family member 12
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
SPAG1 sperm associated antigen 1
SPRYD7 SPRY domain containing 7
STX1A syntaxin 1A (brain)
TEC tec protein tyrosine kinase
TGFBR1 transforming growth factor, beta receptor 1
THBS3 thrombospondin 3
TMEM159 transmembrane protein 159
TNNT1 troponin T type 1 (skeletal, slow)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
UNC13B unc-13 homolog B (C. elegans)
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZDHHC14 zinc finger, DHHC-type containing 14
ZMAT3 zinc finger, matrin-type 3
ZNF10 zinc finger protein 10
ZNF250 zinc finger protein 250
ZNF354A zinc finger protein 354A
ZNHIT2 zinc finger, HIT-type containing 2