methylbenzethonium chloride-4325 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the methylbenzethonium chloride-4325 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
C1ORF116 chromosome 1 open reading frame 116
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
COPE coatomer protein complex, subunit epsilon
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EDN1 endothelin 1
EGR1 early growth response 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPAS1 endothelial PAS domain protein 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GABARAPL1 GABA(A) receptor-associated protein like 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDS iduronate 2-sulfatase
IL11 interleukin 11
IL1RL1 interleukin 1 receptor-like 1
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF3 Kruppel-like factor 3 (basic)
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT34 keratin 34, type I
LDLR low density lipoprotein receptor
LOC157562 uncharacterized LOC157562
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARS methionyl-tRNA synthetase
MMP10 matrix metallopeptidase 10
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1M metallothionein 1M
NCOA3 nuclear receptor coactivator 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAWR PRKC, apoptosis, WT1, regulator
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4D phosphodiesterase 4D, cAMP-specific
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRR protein tyrosine phosphatase, receptor type, R
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REST RE1-silencing transcription factor
RGS4 regulator of G-protein signaling 4
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SARM1 sterile alpha and TIR motif containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24D SEC24 family member D
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TEP1 telomerase-associated protein 1
TGFB2 transforming growth factor, beta 2
TMEM176A transmembrane protein 176A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRIB3 tribbles pseudokinase 3
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ACOX2 acyl-CoA oxidase 2, branched chain
ACTC1 actin, alpha, cardiac muscle 1
ADGRB2 adhesion G protein-coupled receptor B2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ATAT1 alpha tubulin acetyltransferase 1
ATG10 autophagy related 10
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BEX1 brain expressed, X-linked 1
BTF3P12 basic transcription factor 3 pseudogene 12
C1ORF56 chromosome 1 open reading frame 56
C9ORF40 chromosome 9 open reading frame 40
CAPN15 calpain 15
CCDC106 coiled-coil domain containing 106
CCNE2 cyclin E2
CENPB centromere protein B, 80kDa
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CINP cyclin-dependent kinase 2 interacting protein
CISH cytokine inducible SH2-containing protein
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DNAAF2 dynein, axonemal, assembly factor 2
E2F8 E2F transcription factor 8
EDC4 enhancer of mRNA decapping 4
EFHD2 EF-hand domain family, member D2
EN2 engrailed homeobox 2
EVPL envoplakin
FAM86C1 family with sequence similarity 86, member C1
FBXO2 F-box protein 2
FSCN1 fascin actin-bundling protein 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GEMIN4 gem (nuclear organelle) associated protein 4
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXC13 homeobox C13
HSPA2 heat shock 70kDa protein 2
ITPKB inositol-trisphosphate 3-kinase B
KDM5C lysine (K)-specific demethylase 5C
KRT8P12 keratin 8 pseudogene 12
LRP3 low density lipoprotein receptor-related protein 3
LRRC20 leucine rich repeat containing 20
LRRC6 leucine rich repeat containing 6
LRRC61 leucine rich repeat containing 61
MAGEH1 melanoma antigen family H1
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MCM10 minichromosome maintenance complex component 10
MDFI MyoD family inhibitor
MFGE8 milk fat globule-EGF factor 8 protein
MTERF1 mitochondrial transcription termination factor 1
MUC3B mucin 3B, cell surface associated
MYLK myosin light chain kinase
MYO1F myosin IF
NABP2 nucleic acid binding protein 2
NDP Norrie disease (pseudoglioma)
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NLRX1 NLR family member X1
NPY1R neuropeptide Y receptor Y1
OSGIN1 oxidative stress induced growth inhibitor 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PALMD palmdelphin
PAQR4 progestin and adipoQ receptor family member IV
PAQR6 progestin and adipoQ receptor family member VI
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLK2 polo-like kinase 2
PLXNB3 plexin B3
PMPCA peptidase (mitochondrial processing) alpha
POLL polymerase (DNA directed), lambda
PRR15L proline rich 15-like
PTPRU protein tyrosine phosphatase, receptor type, U
R3HCC1L R3H domain and coiled-coil containing 1-like
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBM38 RNA binding motif protein 38
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUSC2 RUN and SH3 domain containing 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCARA3 scavenger receptor class A, member 3
SETD1A SET domain containing 1A
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLITRK5 SLIT and NTRK-like family, member 5
STAG3 stromal antigen 3
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TLN1 talin 1
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
VN1R1 vomeronasal 1 receptor 1
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF215 zinc finger protein 215
ZNF358 zinc finger protein 358
ZNF41 zinc finger protein 41
ZNF480 zinc finger protein 480
ZNF606 zinc finger protein 606
ZNF668 zinc finger protein 668
ZYX zyxin