methotrexate-6318 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the methotrexate-6318 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ATAT1 alpha tubulin acetyltransferase 1
ATXN2L ataxin 2-like
C14ORF105 chromosome 14 open reading frame 105
C17ORF59 chromosome 17 open reading frame 59
C5ORF45 chromosome 5 open reading frame 45
CALD1 caldesmon 1
CCDC85B coiled-coil domain containing 85B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFAP69 cilia and flagella associated protein 69
CLIP4 CAP-GLY domain containing linker protein family, member 4
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPN2 carboxypeptidase N, polypeptide 2
CREB1 cAMP responsive element binding protein 1
CRELD1 cysteine-rich with EGF-like domains 1
CRTC1 CREB regulated transcription coactivator 1
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DDIT3 DNA-damage-inducible transcript 3
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DMTN dematin actin binding protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAL4 dynein, axonemal, light chain 4
EHF ets homologous factor
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EPS8L1 EPS8-like 1
ETNK2 ethanolamine kinase 2
FAM131B family with sequence similarity 131, member B
FASTKD2 FAST kinase domains 2
FBXL15 F-box and leucine-rich repeat protein 15
FBXO31 F-box protein 31
GABARAPL1 GABA(A) receptor-associated protein like 1
GMPR guanosine monophosphate reductase
GPR17 G protein-coupled receptor 17
GRIK2 glutamate receptor, ionotropic, kainate 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HFE hemochromatosis
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMOX1 heme oxygenase 1
HOXC11 homeobox C11
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL11 interleukin 11
IRF4 interferon regulatory factor 4
IRX4 iroquois homeobox 4
ITGB4 integrin, beta 4
ITGB7 integrin, beta 7
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDM4C lysine (K)-specific demethylase 4C
KLF13 Kruppel-like factor 13
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LAMP1 lysosomal-associated membrane protein 1
MON1B MON1 secretory trafficking family member B
MPI mannose phosphate isomerase
MUC1 mucin 1, cell surface associated
MXD3 MAX dimerization protein 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEURL1 neuralized E3 ubiquitin protein ligase 1
OAZ3 ornithine decarboxylase antizyme 3
OLFML2B olfactomedin-like 2B
OVGP1 oviductal glycoprotein 1, 120kDa
OXLD1 oxidoreductase-like domain containing 1
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PCDHGA10 protocadherin gamma subfamily A, 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE8B phosphodiesterase 8B
PDIA4 protein disulfide isomerase family A, member 4
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLCD1 phospholipase C, delta 1
PLCG1 phospholipase C, gamma 1
PLXNC1 plexin C1
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRKCI protein kinase C, iota
PTCRA pre T-cell antigen receptor alpha
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTK6 protein tyrosine kinase 6
RARG retinoic acid receptor, gamma
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
ROM1 retinal outer segment membrane protein 1
RWDD2A RWD domain containing 2A
SDF2L1 stromal cell-derived factor 2-like 1
SIX3 SIX homeobox 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SSH3 slingshot protein phosphatase 3
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STOM stomatin
TLR2 toll-like receptor 2
TMEM209 transmembrane protein 209
TMEM50B transmembrane protein 50B
TMEM8A transmembrane protein 8A
TMEM8B transmembrane protein 8B
TMSB15A thymosin beta 15a
TRIB3 tribbles pseudokinase 3
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)

decreased expression

Symbol Name
AATF apoptosis antagonizing transcription factor
ACAD10 acyl-CoA dehydrogenase family, member 10
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ATAD5 ATPase family, AAA domain containing 5
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
CDCA8 cell division cycle associated 8
CENPA centromere protein A
CHST10 carbohydrate sulfotransferase 10
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNTNAP3B contactin associated protein-like 3B
CRYBA2 crystallin, beta A2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CSRNP3 cysteine-serine-rich nuclear protein 3
DBF4 DBF4 zinc finger
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEPDC1 DEP domain containing 1
DSPP dentin sialophosphoprotein
EGF epidermal growth factor
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ERN2 endoplasmic reticulum to nucleus signaling 2
EVPL envoplakin
FA2H fatty acid 2-hydroxylase
FAM120C family with sequence similarity 120C
FANCC Fanconi anemia, complementation group C
FCHSD2 FCH and double SH3 domains 2
FEM1C fem-1 homolog c (C. elegans)
FOXN2 forkhead box N2
FSD1 fibronectin type III and SPRY domain containing 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GJC1 gap junction protein, gamma 1, 45kDa
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HIST1H1E histone cluster 1, H1e
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HLX H2.0-like homeobox
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IFT22 intraflagellar transport 22
IL17RA interleukin 17 receptor A
JMJD4 jumonji domain containing 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF20A kinesin family member 20A
KIRREL kin of IRRE like (Drosophila)
LHX6 LIM homeobox 6
LOC100286895 cell division cycle 27 homolog pseudogene
LRP3 low density lipoprotein receptor-related protein 3
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MCM9 minichromosome maintenance complex component 9
MN1 meningioma (disrupted in balanced translocation) 1
NDC80 NDC80 kinetochore complex component
NDE1 nudE neurodevelopment protein 1
NFIL3 nuclear factor, interleukin 3 regulated
NLGN1 neuroligin 1
NMRK1 nicotinamide riboside kinase 1
ONECUT2 one cut homeobox 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PALMD palmdelphin
PCF11 PCF11 cleavage and polyadenylation factor subunit
PCOLCE procollagen C-endopeptidase enhancer
PDLIM2 PDZ and LIM domain 2 (mystique)
PHC1 polyhomeotic homolog 1 (Drosophila)
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLK1 polo-like kinase 1
POU2F1 POU class 2 homeobox 1
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRKCD protein kinase C, delta
PRMT7 protein arginine methyltransferase 7
PSRC1 proline/serine-rich coiled-coil 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGS17 regulator of G-protein signaling 17
SCUBE3 signal peptide, CUB domain, EGF-like 3
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SMG9 SMG9 nonsense mediated mRNA decay factor
SND1-IT1 SND1 intronic transcript 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYTL2 synaptotagmin-like 2
TICAM1 toll-like receptor adaptor molecule 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSKU tsukushi, small leucine rich proteoglycan
TULP4 tubby like protein 4
TXNIP thioredoxin interacting protein
UBQLN4 ubiquilin 4
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
USB1 U6 snRNA biogenesis 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBTB39 zinc finger and BTB domain containing 39
ZFP36 ZFP36 ring finger protein
ZNF254 zinc finger protein 254
ZNF304 zinc finger protein 304
ZNF385D zinc finger protein 385D
ZNF552 zinc finger protein 552
ZNRD1-AS1 ZNRD1 antisense RNA 1