methazolamide-6268 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the methazolamide-6268 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ADAP2 ArfGAP with dual PH domains 2
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALPK1 alpha-kinase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
BAIAP3 BAI1-associated protein 3
C7ORF43 chromosome 7 open reading frame 43
CDKN2A cyclin-dependent kinase inhibitor 2A
CEP250 centrosomal protein 250kDa
CHMP6 charged multivesicular body protein 6
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CYHR1 cysteine/histidine-rich 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DTX2 deltex 2, E3 ubiquitin ligase
EHBP1L1 EH domain binding protein 1-like 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EXPH5 exophilin 5
EZR ezrin
FAM155A family with sequence similarity 155, member A
FAM169A family with sequence similarity 169, member A
FCMR Fc fragment of IgM receptor
FGD1 FYVE, RhoGEF and PH domain containing 1
FGL1 fibrinogen-like 1
FH fumarate hydratase
GLG1 golgi glycoprotein 1
GPR137 G protein-coupled receptor 137
GRM4 glutamate receptor, metabotropic 4
GSPT2 G1 to S phase transition 2
GZMK granzyme K (granzyme 3; tryptase II)
HAPLN1 hyaluronan and proteoglycan link protein 1
HFE hemochromatosis
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HYI hydroxypyruvate isomerase (putative)
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT140 intraflagellar transport 140
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL16 interleukin 16
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITGB4 integrin, beta 4
JUNB jun B proto-oncogene
KMT2A lysine (K)-specific methyltransferase 2A
KREMEN2 kringle containing transmembrane protein 2
LAMC2 laminin, gamma 2
LPAR1 lysophosphatidic acid receptor 1
LRRC37A3 leucine rich repeat containing 37, member A3
LUZP1 leucine zipper protein 1
MAPK8 mitogen-activated protein kinase 8
MLX MLX, MAX dimerization protein
MMRN2 multimerin 2
MOCS1 molybdenum cofactor synthesis 1
MPPE1 metallophosphoesterase 1
MYL10 myosin, light chain 10, regulatory
NOTCH2 notch 2
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PADI1 peptidyl arginine deiminase, type I
PAWR PRKC, apoptosis, WT1, regulator
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRMT7 protein arginine methyltransferase 7
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RANBP1 RAN binding protein 1
RNF122 ring finger protein 122
RPL10L ribosomal protein L10-like
RPL7 ribosomal protein L7
SFTPB surfactant protein B
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMTN smoothelin
SPPL2B signal peptide peptidase like 2B
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCTN1 tectonic family member 1
TMEM121 transmembrane protein 121
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TOP3A topoisomerase (DNA) III alpha
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN9 tetraspanin 9
UBA6 ubiquitin-like modifier activating enzyme 6
UBOX5 U-box domain containing 5
USB1 U6 snRNA biogenesis 1
UTRN utrophin
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF701 zinc finger protein 701

decreased expression

Symbol Name
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANKRD10 ankyrin repeat domain 10
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ATG2B autophagy related 2B
ATP11B ATPase, class VI, type 11B
C17ORF80 chromosome 17 open reading frame 80
CAPN15 calpain 15
CBR4 carbonyl reductase 4
CCDC176 coiled-coil domain containing 176
CCDC6 coiled-coil domain containing 6
CCDC88C coiled-coil domain containing 88C
CEP72 centrosomal protein 72kDa
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLDN15 claudin 15
CLDND1 claudin domain containing 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CROT carnitine O-octanoyltransferase
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DAZAP1 DAZ associated protein 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTWD1 DTW domain containing 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
F8 coagulation factor VIII, procoagulant component
FASTKD5 FAST kinase domains 5
FGD6 FYVE, RhoGEF and PH domain containing 6
GATA6 GATA binding protein 6
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GDAP2 ganglioside induced differentiation associated protein 2
GLCE glucuronic acid epimerase
GMIP GEM interacting protein
HIST1H1D histone cluster 1, H1d
HIST1H2AC histone cluster 1, H2ac
HOOK1 hook microtubule-tethering protein 1
IL17RA interleukin 17 receptor A
IMPACT impact RWD domain protein
IQSEC1 IQ motif and Sec7 domain 1
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIAA0125 KIAA0125
KIAA0922 KIAA0922
KIF18A kinesin family member 18A
LNPEP leucyl/cystinyl aminopeptidase
LYPD3 LY6/PLAUR domain containing 3
MAGEF1 melanoma antigen family F1
MBOAT2 membrane bound O-acyltransferase domain containing 2
MCM3AP-AS1 MCM3AP antisense RNA 1
MED15 mediator complex subunit 15
MEIS1 Meis homeobox 1
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NCAPH non-SMC condensin I complex, subunit H
NPIPB15 nuclear pore complex interacting protein family, member B15
ODF2 outer dense fiber of sperm tails 2
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PARD6A par-6 family cell polarity regulator alpha
PARG poly (ADP-ribose) glycohydrolase
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKN1 protein kinase N1
PPL periplakin
PQLC1 PQ loop repeat containing 1
PRR3 proline rich 3
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTCD2 pentatricopeptide repeat domain 2
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RBM38 RNA binding motif protein 38
RCOR3 REST corepressor 3
RHOBTB1 Rho-related BTB domain containing 1
RNF25 ring finger protein 25
SCML1 sex comb on midleg-like 1 (Drosophila)
SH2D4A SH2 domain containing 4A
SLC25A40 solute carrier family 25, member 40
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNX6 sorting nexin 6
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYT17 synaptotagmin XVII
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TNRC6B trinucleotide repeat containing 6B
TSPYL5 TSPY-like 5
UBE2S ubiquitin-conjugating enzyme E2S
VAV1 vav 1 guanine nucleotide exchange factor
WBP2 WW domain binding protein 2
WDR7 WD repeat domain 7
XYLT2 xylosyltransferase II
ZC3H3 zinc finger CCCH-type containing 3
ZFHX3 zinc finger homeobox 3
ZNF205 zinc finger protein 205
ZNF23 zinc finger protein 23
ZNF280D zinc finger protein 280D
ZNF408 zinc finger protein 408
ZNF552 zinc finger protein 552
ZNF787 zinc finger protein 787
ZXDC ZXD family zinc finger C