methazolamide-3474 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the methazolamide-3474 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACAD10 acyl-CoA dehydrogenase family, member 10
AK2 adenylate kinase 2
ALMS1 Alstrom syndrome protein 1
ALPK1 alpha-kinase 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARTN artemin
ATP2A3 ATPase, Ca++ transporting, ubiquitous
B9D2 B9 protein domain 2
BCL9 B-cell CLL/lymphoma 9
BCO1 beta-carotene oxygenase 1
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD82 CD82 molecule
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDK19 cyclin-dependent kinase 19
CFLAR CASP8 and FADD-like apoptosis regulator
CHRM3 cholinergic receptor, muscarinic 3
CYTH1 cytohesin 1
DCAF13 DDB1 and CUL4 associated factor 13
DUSP10 dual specificity phosphatase 10
DVL2 dishevelled segment polarity protein 2
EGFR epidermal growth factor receptor
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
ERCC4 excision repair cross-complementation group 4
FBXL18 F-box and leucine-rich repeat protein 18
FOXP3 forkhead box P3
FRMD1 FERM domain containing 1
GAS7 growth arrest-specific 7
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLRX3 glutaredoxin 3
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GYG2 glycogenin 2
HFE hemochromatosis
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
HYI hydroxypyruvate isomerase (putative)
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
ITGB6 integrin, beta 6
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KRBOX4 KRAB box domain containing 4
KRT17 keratin 17, type I
KRT85 keratin 85, type II
LDB1 LIM domain binding 1
LINC00341 long intergenic non-protein coding RNA 341
LOC157562 uncharacterized LOC157562
MAN2A2 mannosidase, alpha, class 2A, member 2
MARC2 mitochondrial amidoxime reducing component 2
MARK2 MAP/microtubule affinity-regulating kinase 2
N4BP1 NEDD4 binding protein 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NF1 neurofibromin 1
NOL12 nucleolar protein 12
NR1I2 nuclear receptor subfamily 1, group I, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFML2A olfactomedin-like 2A
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDIA2 protein disulfide isomerase family A, member 2
PDLIM7 PDZ and LIM domain 7 (enigma)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKNOX1 PBX/knotted 1 homeobox 1
PLIN2 perilipin 2
POMT2 protein-O-mannosyltransferase 2
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PSEN2 presenilin 2
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
RASAL2 RAS protein activator like 2
RER1 retention in endoplasmic reticulum sorting receptor 1
RGS12 regulator of G-protein signaling 12
RNF2 ring finger protein 2
RPLP2 ribosomal protein, large, P2
SAMD4A sterile alpha motif domain containing 4A
SCAND2P SCAN domain containing 2 pseudogene
SGPL1 sphingosine-1-phosphate lyase 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPTBN1 spectrin, beta, non-erythrocytic 1
SRCAP Snf2-related CREBBP activator protein
SRPR signal recognition particle receptor (docking protein)
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STK11 serine/threonine kinase 11
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMC6 transmembrane channel-like 6
TMPRSS15 transmembrane protease, serine 15
TRIM16 tripartite motif containing 16
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VPS13B vacuolar protein sorting 13 homolog B (yeast)
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
YIPF2 Yip1 domain family, member 2
ZBTB22 zinc finger and BTB domain containing 22
ZCCHC4 zinc finger, CCHC domain containing 4
ZNF202 zinc finger protein 202
ZNF350 zinc finger protein 350
ZNF41 zinc finger protein 41
ZNF652 zinc finger protein 652
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
AHCYL2 adenosylhomocysteinase-like 2
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
APOD apolipoprotein D
ARL15 ADP-ribosylation factor-like 15
BATF basic leucine zipper transcription factor, ATF-like
C11ORF80 chromosome 11 open reading frame 80
C2ORF54 chromosome 2 open reading frame 54
C5AR2 complement component 5a receptor 2
CAMTA2 calmodulin binding transcription activator 2
CASZ1 castor zinc finger 1
CCDC85C coiled-coil domain containing 85C
CD151 CD151 molecule (Raph blood group)
CDK20 cyclin-dependent kinase 20
CDK3 cyclin-dependent kinase 3
CDR2L cerebellar degeneration-related protein 2-like
CHST10 carbohydrate sulfotransferase 10
CISH cytokine inducible SH2-containing protein
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL9A2 collagen, type IX, alpha 2
CORT cortistatin
CRLF1 cytokine receptor-like factor 1
CRY2 cryptochrome circadian clock 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CXORF56 chromosome X open reading frame 56
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DGKE diacylglycerol kinase, epsilon 64kDa
DNM1 dynamin 1
DSCAM Down syndrome cell adhesion molecule
EHD3 EH-domain containing 3
ELOVL4 ELOVL fatty acid elongase 4
ERCC5 excision repair cross-complementation group 5
FAM169A family with sequence similarity 169, member A
FKBP10 FK506 binding protein 10, 65 kDa
GBP2 guanylate binding protein 2, interferon-inducible
GPRC5C G protein-coupled receptor, class C, group 5, member C
HLA-J major histocompatibility complex, class I, J (pseudogene)
IFT81 intraflagellar transport 81
IGSF1 immunoglobulin superfamily, member 1
IRF1 interferon regulatory factor 1
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KDM5C lysine (K)-specific demethylase 5C
KIAA0319L KIAA0319-like
KIAA0355 KIAA0355
KLHL21 kelch-like family member 21
LAMA5 laminin, alpha 5
LRRC61 leucine rich repeat containing 61
LY6G5C lymphocyte antigen 6 complex, locus G5C
LYRM9 LYR motif containing 9
MAMLD1 mastermind-like domain containing 1
MAP9 microtubule-associated protein 9
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBNL3 muscleblind-like splicing regulator 3
MFAP2 microfibrillar-associated protein 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MNX1 motor neuron and pancreas homeobox 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5C 5', 3'-nucleotidase, cytosolic
PARPBP PARP1 binding protein
PLA2G3 phospholipase A2, group III
PMCH pro-melanin-concentrating hormone
PPT2 palmitoyl-protein thioesterase 2
PRPH peripherin
PRR7 proline rich 7 (synaptic)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
QTRT1 queuine tRNA-ribosyltransferase 1
RNF123 ring finger protein 123
RPH3AL rabphilin 3A-like (without C2 domains)
RWDD3 RWD domain containing 3
SAV1 salvador family WW domain containing protein 1
SDF2 stromal cell-derived factor 2
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH2D4A SH2 domain containing 4A
SLC12A8 solute carrier family 12, member 8
SLC41A3 solute carrier family 41, member 3
SPATA2L spermatogenesis associated 2-like
SREK1IP1 SREK1-interacting protein 1
THRAP3 thyroid hormone receptor associated protein 3
TMC7 transmembrane channel-like 7
TMEM104 transmembrane protein 104
TMEM115 transmembrane protein 115
TOM1 target of myb1 (chicken)
TRIM25 tripartite motif containing 25
TTBK2 tau tubulin kinase 2
TTC26 tetratricopeptide repeat domain 26
TUBA3C tubulin, alpha 3c
WBP2 WW domain binding protein 2
XAB2 XPA binding protein 2
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF205 zinc finger protein 205
ZNF480 zinc finger protein 480
ZNF668 zinc finger protein 668