methanthelinium bromide-6254 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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192 genes differentially expressed following the methanthelinium bromide-6254 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADAM23 ADAM metallopeptidase domain 23
AHCYL2 adenosylhomocysteinase-like 2
AHDC1 AT hook, DNA binding motif, containing 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALS2CL ALS2 C-terminal like
ARL3 ADP-ribosylation factor-like 3
ARMC4 armadillo repeat containing 4
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AVL9 AVL9 homolog (S. cerevisiase)
BAAT bile acid CoA:amino acid N-acyltransferase
BIN1 bridging integrator 1
BMP4 bone morphogenetic protein 4
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CD4 CD4 molecule
CD82 CD82 molecule
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CHKB choline kinase beta
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COL7A1 collagen, type VII, alpha 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CRELD1 cysteine-rich with EGF-like domains 1
CRISP1 cysteine-rich secretory protein 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTTN cortactin
CYHR1 cysteine/histidine-rich 1
CYLD cylindromatosis (turban tumor syndrome)
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DEPDC5 DEP domain containing 5
DMBT1 deleted in malignant brain tumors 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FBXO9 F-box protein 9
FHL1 four and a half LIM domains 1
FOXN2 forkhead box N2
GJA4 gap junction protein, alpha 4, 37kDa
GMEB1 glucocorticoid modulatory element binding protein 1
HIST1H2BN histone cluster 1, H2bn
HIST1H4A histone cluster 1, H4a
HPCA hippocalcin
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL27RA interleukin 27 receptor, alpha
INADL InaD-like (Drosophila)
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KAT8 K(lysine) acetyltransferase 8
KIAA0930 KIAA0930
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
KRT24 keratin 24, type I
LMBR1L limb development membrane protein 1-like
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MAST3 microtubule associated serine/threonine kinase 3
MECP2 methyl CpG binding protein 2
MID1 midline 1
MYOF myoferlin
NR2C1 nuclear receptor subfamily 2, group C, member 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLSCR3 phospholipid scramblase 3
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
QKI QKI, KH domain containing, RNA binding
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPL18 ribosomal protein L18
SFTPB surfactant protein B
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMTN smoothelin
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPPL2B signal peptide peptidase like 2B
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
TAOK1 TAO kinase 1
TLE2 transducin-like enhancer of split 2
TLN2 talin 2
TMEM259 transmembrane protein 259
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TOM1 target of myb1 (chicken)
UBE3A ubiquitin protein ligase E3A
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZNF423 zinc finger protein 423
ZNF510 zinc finger protein 510
ZNF609 zinc finger protein 609
ZNF675 zinc finger protein 675
ZNF710 zinc finger protein 710
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABLIM3 actin binding LIM protein family, member 3
AGBL5 ATP/GTP binding protein-like 5
ALG12 ALG12, alpha-1,6-mannosyltransferase
APH1B APH1B gamma secretase subunit
ARMC6 armadillo repeat containing 6
ASB9 ankyrin repeat and SOCS box containing 9
ASCC2 activating signal cointegrator 1 complex subunit 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATM ATM serine/threonine kinase
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BAX BCL2-associated X protein
C11ORF71 chromosome 11 open reading frame 71
C19ORF40 chromosome 19 open reading frame 40
CASZ1 castor zinc finger 1
CBX4 chromobox homolog 4
CCDC85C coiled-coil domain containing 85C
CENPJ centromere protein J
CENPQ centromere protein Q
CEP72 centrosomal protein 72kDa
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL4A5 collagen, type IV, alpha 5
COL9A2 collagen, type IX, alpha 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DENND4C DENN/MADD domain containing 4C
DEPTOR DEP domain containing MTOR-interacting protein
F3 coagulation factor III (thromboplastin, tissue factor)
F8 coagulation factor VIII, procoagulant component
FLCN folliculin
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GALK1 galactokinase 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNL1 guanine nucleotide binding protein-like 1
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2AG histone cluster 1, H2ag
HTRA1 HtrA serine peptidase 1
IFT81 intraflagellar transport 81
IMPACT impact RWD domain protein
ITGA6 integrin, alpha 6
ITPKC inositol-trisphosphate 3-kinase C
LOC100272216 uncharacterized LOC100272216
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC642236 FSHD region gene 1 pseudogene
LRP3 low density lipoprotein receptor-related protein 3
LRP5 low density lipoprotein receptor-related protein 5
LRRC49 leucine rich repeat containing 49
LZTR1 leucine-zipper-like transcription regulator 1
MITF microphthalmia-associated transcription factor
MTCL1 microtubule crosslinking factor 1
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYO1E myosin IE
NBEAL2 neurobeachin-like 2
NPIPB15 nuclear pore complex interacting protein family, member B15
NPY5R neuropeptide Y receptor Y5
NR2C2 nuclear receptor subfamily 2, group C, member 2
NT5C 5', 3'-nucleotidase, cytosolic
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PCSK7 proprotein convertase subtilisin/kexin type 7
PDGFRL platelet-derived growth factor receptor-like
PILRB paired immunoglobin-like type 2 receptor beta
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLAA phospholipase A2-activating protein
PMM1 phosphomannomutase 1
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PTTG3P pituitary tumor-transforming 3, pseudogene
RBL1 retinoblastoma-like 1
RINT1 RAD50 interactor 1
RNF126P1 ring finger protein 126 pseudogene 1
RP2 retinitis pigmentosa 2 (X-linked recessive)
S100A6 S100 calcium binding protein A6
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SETD8 SET domain containing (lysine methyltransferase) 8
SH2B2 SH2B adaptor protein 2
SND1-IT1 SND1 intronic transcript 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM2 transmembrane protein 2
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TPCN1 two pore segment channel 1
TSPAN14 tetraspanin 14
ULBP2 UL16 binding protein 2
USP36 ubiquitin specific peptidase 36
VEGFC vascular endothelial growth factor C
ZNF280D zinc finger protein 280D
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721