metformin-1858 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the metformin-1858 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN4 actinin, alpha 4
ADAM17 ADAM metallopeptidase domain 17
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
APP amyloid beta (A4) precursor protein
ATF6B activating transcription factor 6 beta
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATXN3 ataxin 3
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BLZF1 basic leucine zipper nuclear factor 1
BMP8B bone morphogenetic protein 8b
BRD4 bromodomain containing 4
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BRIX1 BRX1, biogenesis of ribosomes
C16ORF59 chromosome 16 open reading frame 59
C1ORF109 chromosome 1 open reading frame 109
CAMKMT calmodulin-lysine N-methyltransferase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDR2L cerebellar degeneration-related protein 2-like
CEP295 centrosomal protein 295kDa
CEP63 centrosomal protein 63kDa
CORT cortistatin
CREBZF CREB/ATF bZIP transcription factor
CUL5 cullin 5
DEPDC1 DEP domain containing 1
DHODH dihydroorotate dehydrogenase (quinone)
DLG1 discs, large homolog 1 (Drosophila)
DOCK10 dedicator of cytokinesis 10
ELF4 E74-like factor 4 (ets domain transcription factor)
FAM127A family with sequence similarity 127, member A
FAM63B family with sequence similarity 63, member B
FBXO9 F-box protein 9
FECH ferrochelatase
FSCN1 fascin actin-bundling protein 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GBAS glioblastoma amplified sequence
GK3P glycerol kinase 3 pseudogene
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GOSR2 golgi SNAP receptor complex member 2
H2AFX H2A histone family, member X
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HBEGF heparin-binding EGF-like growth factor
HDLBP high density lipoprotein binding protein
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HMGN5 high mobility group nucleosome binding domain 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KCTD20 potassium channel tetramerization domain containing 20
KRIT1 KRIT1, ankyrin repeat containing
MAPKAPK5-AS1 MAPKAPK5 antisense RNA 1
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MDFIC MyoD family inhibitor domain containing
MED7 mediator complex subunit 7
MRPL44 mitochondrial ribosomal protein L44
NTSR1 neurotensin receptor 1 (high affinity)
NUP188 nucleoporin 188kDa
PAQR3 progestin and adipoQ receptor family member III
PCCA propionyl CoA carboxylase, alpha polypeptide
PDS5A PDS5 cohesin associated factor A
PHTF2 putative homeodomain transcription factor 2
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAGL1 pleiomorphic adenoma gene-like 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PRRC2B proline-rich coiled-coil 2B
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RAD17 RAD17 homolog (S. pombe)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RARS arginyl-tRNA synthetase
RPL10 ribosomal protein L10
RPS2 ribosomal protein S2
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RWDD3 RWD domain containing 3
RXRA retinoid X receptor, alpha
S100A11 S100 calcium binding protein A11
SAT1 spermidine/spermine N1-acetyltransferase 1
SERBP1 SERPINE1 mRNA binding protein 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNX29P2 sorting nexin 29 pseudogene 2
SOCS6 suppressor of cytokine signaling 6
SORD sorbitol dehydrogenase
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
SUGP1 SURP and G patch domain containing 1
SYK spleen tyrosine kinase
TCF3 transcription factor 3
TLE4 transducin-like enhancer of split 4
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM38B transmembrane protein 38B
TMEM70 transmembrane protein 70
TSPAN3 tetraspanin 3
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VIPR2 vasoactive intestinal peptide receptor 2
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
ZNF324 zinc finger protein 324

decreased expression

Symbol Name
ACOT13 acyl-CoA thioesterase 13
ALPK1 alpha-kinase 1
APH1B APH1B gamma secretase subunit
ARHGAP10 Rho GTPase activating protein 10
ARMC6 armadillo repeat containing 6
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BTNL3 butyrophilin-like 3
C17ORF70 chromosome 17 open reading frame 70
C1ORF35 chromosome 1 open reading frame 35
C3 complement component 3
CBX4 chromobox homolog 4
CCDC85C coiled-coil domain containing 85C
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDADC1 cytidine and dCMP deaminase domain containing 1
CHST10 carbohydrate sulfotransferase 10
CLSPN claspin
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRY2 cryptochrome circadian clock 2
DBF4B DBF4 zinc finger B
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM188A family with sequence similarity 188, member A
FAM63A family with sequence similarity 63, member A
FBXL7 F-box and leucine-rich repeat protein 7
FBXW12 F-box and WD repeat domain containing 12
FLCN folliculin
GINS4 GINS complex subunit 4 (Sld5 homolog)
GIPC1 GIPC PDZ domain containing family, member 1
GSPT2 G1 to S phase transition 2
GSTA4 glutathione S-transferase alpha 4
GUSBP3 glucuronidase, beta pseudogene 3
HAUS2 HAUS augmin-like complex, subunit 2
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HIRA histone cell cycle regulator
HP haptoglobin
HYAL2 hyaluronoglucosaminidase 2
INO80D INO80 complex subunit D
IRF1 interferon regulatory factor 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KDM8 lysine (K)-specific demethylase 8
KIAA0894 KIAA0894 protein
KIFC1 kinesin family member C1
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LOC157562 uncharacterized LOC157562
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC37A3 leucine rich repeat containing 37, member A3
MTERF1 mitochondrial transcription termination factor 1
MYO1E myosin IE
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PHC2 polyhomeotic homolog 2 (Drosophila)
POLH polymerase (DNA directed), eta
PRAF2 PRA1 domain family, member 2
PRDM13 PR domain containing 13
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
QTRT1 queuine tRNA-ribosyltransferase 1
RIN1 Ras and Rab interactor 1
RNF122 ring finger protein 122
RNF2 ring finger protein 2
RPL32 ribosomal protein L32
RPL41 ribosomal protein L41
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RRP1 ribosomal RNA processing 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCAI suppressor of cancer cell invasion
SH2D3C SH2 domain containing 3C
SHPK sedoheptulokinase
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMA4 glucuronidase, beta pseudogene
SNHG20 small nucleolar RNA host gene 20
SNRPN small nuclear ribonucleoprotein polypeptide N
SNX15 sorting nexin 15
SPATS2 spermatogenesis associated, serine-rich 2
STX1A syntaxin 1A (brain)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCTN1 tectonic family member 1
TGFBR3 transforming growth factor, beta receptor III
THBS4 thrombospondin 4
THEM6 thioesterase superfamily member 6
TRAIP TRAF interacting protein
TTBK2 tau tubulin kinase 2
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
USP19 ubiquitin specific peptidase 19
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZDHHC24 zinc finger, DHHC-type containing 24
ZNF264 zinc finger protein 264
ZNF350 zinc finger protein 350
ZNF574 zinc finger protein 574
ZNF652 zinc finger protein 652