metanephrine-2015 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the metanephrine-2015 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ABHD3 abhydrolase domain containing 3
ACVRL1 activin A receptor type II-like 1
AKTIP AKT interacting protein
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARHGAP33 Rho GTPase activating protein 33
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL7A B-cell CLL/lymphoma 7A
BMP1 bone morphogenetic protein 1
C19ORF66 chromosome 19 open reading frame 66
C20ORF27 chromosome 20 open reading frame 27
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CCDC85C coiled-coil domain containing 85C
CCPG1 cell cycle progression 1
CD1D CD1d molecule
CD69 CD69 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
COG5 component of oligomeric golgi complex 5
COL8A2 collagen, type VIII, alpha 2
CTSS cathepsin S
CYLD cylindromatosis (turban tumor syndrome)
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EID1 EP300 interacting inhibitor of differentiation 1
EIF4E eukaryotic translation initiation factor 4E
ELMO2 engulfment and cell motility 2
EVI5 ecotropic viral integration site 5
FCHO1 FCH domain only 1
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H4J histone cluster 1, H4j
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRAK3 interleukin-1 receptor-associated kinase 3
KIAA1109 KIAA1109
KIFC1 kinesin family member C1
KLHL18 kelch-like family member 18
KLHL20 kelch-like family member 20
LHB luteinizing hormone beta polypeptide
LIN7C lin-7 homolog C (C. elegans)
LTB4R leukotriene B4 receptor
MAGEB2 melanoma antigen family B2
MAP7D3 MAP7 domain containing 3
MICALL1 MICAL-like 1
MTAP methylthioadenosine phosphorylase
PARP16 poly (ADP-ribose) polymerase family, member 16
PCIF1 PDX1 C-terminal inhibiting factor 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4D phosphodiesterase 4D, cAMP-specific
PELI2 pellino E3 ubiquitin protein ligase family member 2
PIDD1 p53-induced death domain protein 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLD2 phospholipase D2
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PSG3 pregnancy specific beta-1-glycoprotein 3
RAD23B RAD23 homolog B (S. cerevisiae)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBM25 RNA binding motif protein 25
RGS1 regulator of G-protein signaling 1
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPS2 ribosomal protein S2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SLC25A40 solute carrier family 25, member 40
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SNX19 sorting nexin 19
SOCS5 suppressor of cytokine signaling 5
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STXBP3 syntaxin binding protein 3
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYT11 synaptotagmin XI
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TES testin LIM domain protein
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TMCO1 transmembrane and coiled-coil domains 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNRC6B trinucleotide repeat containing 6B
TTC37 tetratricopeptide repeat domain 37
UBE2O ubiquitin-conjugating enzyme E2O
USF2 upstream transcription factor 2, c-fos interacting
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WWC2 WW and C2 domain containing 2
YLPM1 YLP motif containing 1
ZC2HC1A zinc finger, C2HC-type containing 1A
ZMYM1 zinc finger, MYM-type 1
ZNF224 zinc finger protein 224
ZNF253 zinc finger protein 253
ZNF280D zinc finger protein 280D
ZNF500 zinc finger protein 500

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACACA acetyl-CoA carboxylase alpha
ADAM15 ADAM metallopeptidase domain 15
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ALS2CL ALS2 C-terminal like
ANKRD11 ankyrin repeat domain 11
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARL2 ADP-ribosylation factor-like 2
ATF7IP2 activating transcription factor 7 interacting protein 2
BCL7B B-cell CLL/lymphoma 7B
C11ORF68 chromosome 11 open reading frame 68
C1ORF35 chromosome 1 open reading frame 35
C2ORF44 chromosome 2 open reading frame 44
C6ORF47 chromosome 6 open reading frame 47
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLN3 ceroid-lipofuscinosis, neuronal 3
COPS7B COP9 signalosome subunit 7B
COQ6 coenzyme Q6 monooxygenase
CPA2 carboxypeptidase A2 (pancreatic)
CSRNP2 cysteine-serine-rich nuclear protein 2
CTSG cathepsin G
DBF4B DBF4 zinc finger B
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
ECHDC2 enoyl CoA hydratase domain containing 2
ECSIT ECSIT signalling integrator
EDC3 enhancer of mRNA decapping 3
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
ERCC5 excision repair cross-complementation group 5
EXOC5 exocyst complex component 5
FMO4 flavin containing monooxygenase 4
GAB2 GRB2-associated binding protein 2
GBAP1 glucosidase, beta, acid pseudogene 1
GMPPA GDP-mannose pyrophosphorylase A
GMPPB GDP-mannose pyrophosphorylase B
GPR27 G protein-coupled receptor 27
GSR glutathione reductase
GSTM5 glutathione S-transferase mu 5
HK1 hexokinase 1
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INO80D INO80 complex subunit D
KAT2A K(lysine) acetyltransferase 2A
KCTD20 potassium channel tetramerization domain containing 20
KRT38 keratin 38, type I
LAS1L LAS1-like (S. cerevisiae)
MKKS McKusick-Kaufman syndrome
MPDU1 mannose-P-dolichol utilization defect 1
MTRF1 mitochondrial translational release factor 1
MX2 MX dynamin-like GTPase 2
MYLIP myosin regulatory light chain interacting protein
MYO19 myosin XIX
NADSYN1 NAD synthetase 1
NCF1C neutrophil cytosolic factor 1C pseudogene
NCKAP1L NCK-associated protein 1-like
NECAB3 N-terminal EF-hand calcium binding protein 3
NEK11 NIMA-related kinase 11
NSD1 nuclear receptor binding SET domain protein 1
OR7E37P olfactory receptor, family 7, subfamily E, member 37 pseudogene
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCDHGB5 protocadherin gamma subfamily B, 5
PCSK7 proprotein convertase subtilisin/kexin type 7
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PEMT phosphatidylethanolamine N-methyltransferase
PGPEP1 pyroglutamyl-peptidase I
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PKN1 protein kinase N1
PSAT1 phosphoserine aminotransferase 1
PTCD1 pentatricopeptide repeat domain 1
RAB8B RAB8B, member RAS oncogene family
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RBMS3 RNA binding motif, single stranded interacting protein 3
RPUSD2 RNA pseudouridylate synthase domain containing 2
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SIRT6 sirtuin 6
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SNX6 sorting nexin 6
SRRD SRR1 domain containing
SSNA1 Sjogren syndrome nuclear autoantigen 1
STRA13 stimulated by retinoic acid 13
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TCTN2 tectonic family member 2
TMEM50A transmembrane protein 50A
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
UBIAD1 UbiA prenyltransferase domain containing 1
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
USB1 U6 snRNA biogenesis 1
WDR77 WD repeat domain 77
XDH xanthine dehydrogenase
YIPF1 Yip1 domain family, member 1
YY2 YY2 transcription factor
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF606 zinc finger protein 606