metamizole sodium-2175 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the metamizole sodium-2175 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADD2 adducin 2 (beta)
AHI1 Abelson helper integration site 1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
APOC4 apolipoprotein C-IV
BRS3 bombesin-like receptor 3
C11ORF16 chromosome 11 open reading frame 16
C17ORF59 chromosome 17 open reading frame 59
C1ORF68 chromosome 1 open reading frame 68
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAT catalase
CD22 CD22 molecule
CD70 CD70 molecule
CETN1 centrin, EF-hand protein, 1
CLTA clathrin, light chain A
CPB2 carboxypeptidase B2 (plasma)
CPEB3 cytoplasmic polyadenylation element binding protein 3
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DAGLA diacylglycerol lipase, alpha
DLG3 discs, large homolog 3 (Drosophila)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DPYSL4 dihydropyrimidinase-like 4
EGFR epidermal growth factor receptor
ELN elastin
FAM182B family with sequence similarity 182, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FGF12 fibroblast growth factor 12
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FURIN furin (paired basic amino acid cleaving enzyme)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAS8 growth arrest-specific 8
GJA9 gap junction protein, alpha 9, 59kDa
GJB4 gap junction protein, beta 4, 30.3kDa
GRIP2 glutamate receptor interacting protein 2
GRM1 glutamate receptor, metabotropic 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIF3A hypoxia inducible factor 3, alpha subunit
HIST1H2BO histone cluster 1, H2bo
IFITM1 interferon induced transmembrane protein 1
IL36G interleukin 36, gamma
IQSEC1 IQ motif and Sec7 domain 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KCTD2 potassium channel tetramerization domain containing 2
KLHDC8A kelch domain containing 8A
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAGEA5 melanoma antigen family A5
MALL mal, T-cell differentiation protein-like
MAPK11 mitogen-activated protein kinase 11
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MSI1 musashi RNA-binding protein 1
MXD4 MAX dimerization protein 4
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYO1E myosin IE
NCKIPSD NCK interacting protein with SH3 domain
NF2 neurofibromin 2 (merlin)
NKX2-1 NK2 homeobox 1
NPPA natriuretic peptide A
PCDH9 protocadherin 9
PCSK7 proprotein convertase subtilisin/kexin type 7
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM7 PDZ and LIM domain 7 (enigma)
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYCRL pyrroline-5-carboxylate reductase-like
RAB6B RAB6B, member RAS oncogene family
RASAL2 RAS protein activator like 2
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RB1 retinoblastoma 1
REC8 REC8 meiotic recombination protein
RHEB Ras homolog enriched in brain
SCUBE3 signal peptide, CUB domain, EGF-like 3
SDS serine dehydratase
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SELPLG selectin P ligand
SH2D4A SH2 domain containing 4A
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC17A2 solute carrier family 17, member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOCS3 suppressor of cytokine signaling 3
SPTBN1 spectrin, beta, non-erythrocytic 1
TAS2R14 taste receptor, type 2, member 14
TBX10 T-box 10
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCP10 t-complex 10
TIMELESS timeless circadian clock
TMEM176A transmembrane protein 176A
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TXK TXK tyrosine kinase
ZC3H7B zinc finger CCCH-type containing 7B
ZIC3 Zic family member 3
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
AMPD2 adenosine monophosphate deaminase 2
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ATAD3A ATPase family, AAA domain containing 3A
ATXN2 ataxin 2
BHLHE41 basic helix-loop-helix family, member e41
BPHL biphenyl hydrolase-like (serine hydrolase)
BSPRY B-box and SPRY domain containing
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C16ORF59 chromosome 16 open reading frame 59
C1ORF159 chromosome 1 open reading frame 159
C2CD2 C2 calcium-dependent domain containing 2
C6ORF47 chromosome 6 open reading frame 47
CCDC9 coiled-coil domain containing 9
CCRL2 chemokine (C-C motif) receptor-like 2
CD9 CD9 molecule
CDR2L cerebellar degeneration-related protein 2-like
CLCF1 cardiotrophin-like cytokine factor 1
CLCN5 chloride channel, voltage-sensitive 5
CLSPN claspin
COL9A2 collagen, type IX, alpha 2
CPNE1 copine I
CPTP ceramide-1-phosphate transfer protein
DCAF13 DDB1 and CUL4 associated factor 13
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DEPTOR DEP domain containing MTOR-interacting protein
DNAL4 dynein, axonemal, light chain 4
DOK3 docking protein 3
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FMO4 flavin containing monooxygenase 4
GALE UDP-galactose-4-epimerase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLCE glucuronic acid epimerase
GPR22 G protein-coupled receptor 22
GRAMD1B GRAM domain containing 1B
GSTCD glutathione S-transferase, C-terminal domain containing
GSTZ1 glutathione S-transferase zeta 1
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HHLA3 HERV-H LTR-associating 3
HIST1H2AM histone cluster 1, H2am
HIST1H2BH histone cluster 1, H2bh
ICK intestinal cell (MAK-like) kinase
IFI6 interferon, alpha-inducible protein 6
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFT81 intraflagellar transport 81
INO80D INO80 complex subunit D
ITPKB inositol-trisphosphate 3-kinase B
KLF13 Kruppel-like factor 13
KRT8P12 keratin 8 pseudogene 12
LIG4 ligase IV, DNA, ATP-dependent
LOC390998 ribosomal protein L10 pseudogene
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK3 mitogen-activated protein kinase 3
MEFV Mediterranean fever
MGC12488
MTMR12 myotubularin related protein 12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NARFL nuclear prelamin A recognition factor-like
NPM3 nucleophosmin/nucleoplasmin 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCDHGA10 protocadherin gamma subfamily A, 10
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PHC1 polyhomeotic homolog 1 (Drosophila)
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PMFBP1 polyamine modulated factor 1 binding protein 1
POM121 POM121 transmembrane nucleoporin
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RETN resistin
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RUSC2 RUN and SH3 domain containing 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SETD1A SET domain containing 1A
STAT5A signal transducer and activator of transcription 5A
SYCP2 synaptonemal complex protein 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAS2R10 taste receptor, type 2, member 10
THRAP3 thyroid hormone receptor associated protein 3
TIGD6 tigger transposable element derived 6
TMEM187 transmembrane protein 187
TMEM242 transmembrane protein 242
TRAF2 TNF receptor-associated factor 2
TRPS1 trichorhinophalangeal syndrome I
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSPAN13 tetraspanin 13
UNC13B unc-13 homolog B (C. elegans)
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZBTB25 zinc finger and BTB domain containing 25
ZBTB6 zinc finger and BTB domain containing 6
ZC4H2 zinc finger, C4H2 domain containing
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF215 zinc finger protein 215
ZNF426 zinc finger protein 426
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76