metacycline-7321 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the metacycline-7321 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BHLHE41 basic helix-loop-helix family, member e41
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC181 coiled-coil domain containing 181
CCP110 centriolar coiled coil protein 110kDa
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
DAGLA diacylglycerol lipase, alpha
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGKE diacylglycerol kinase, epsilon 64kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIEXF digestive organ expansion factor homolog (zebrafish)
DVL2 dishevelled segment polarity protein 2
EPHB2 EPH receptor B2
EXOSC1 exosome component 1
FAM174B family with sequence similarity 174, member B
FAM212B family with sequence similarity 212, member B
FAM63B family with sequence similarity 63, member B
FBXO41 F-box protein 41
FECH ferrochelatase
FER fer (fps/fes related) tyrosine kinase
FRK fyn-related Src family tyrosine kinase
FZD7 frizzled class receptor 7
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GEMIN8 gem (nuclear organelle) associated protein 8
GNG3 guanine nucleotide binding protein (G protein), gamma 3
HAMP hepcidin antimicrobial peptide
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIC2 hypermethylated in cancer 2
HPS1 Hermansky-Pudlak syndrome 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IQCG IQ motif containing G
ITGB4 integrin, beta 4
ITM2C integral membrane protein 2C
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KITLG KIT ligand
KLK3 kallikrein-related peptidase 3
KMT2A lysine (K)-specific methyltransferase 2A
KRT37 keratin 37, type I
LIMCH1 LIM and calponin homology domains 1
LOC644450 uncharacterized LOC644450
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAGEA3 melanoma antigen family A3
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCOLN1 mucolipin 1
MFGE8 milk fat globule-EGF factor 8 protein
MKL1 megakaryoblastic leukemia (translocation) 1
MPL MPL proto-oncogene, thrombopoietin receptor
NF1 neurofibromin 1
NME5 NME/NM23 family member 5
OASL 2'-5'-oligoadenylate synthetase-like
PAPOLA poly(A) polymerase alpha
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAUR plasminogen activator, urokinase receptor
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POMT2 protein-O-mannosyltransferase 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRLR prolactin receptor
PRSS53 protease, serine, 53
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RAB11B RAB11B, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAD52 RAD52 homolog (S. cerevisiae)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
REL v-rel avian reticuloendotheliosis viral oncogene homolog
REM1 RAS (RAD and GEM)-like GTP-binding 1
RND1 Rho family GTPase 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SBF1 SET binding factor 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TADA3 transcriptional adaptor 3
TBC1D2 TBC1 domain family, member 2
TCTN2 tectonic family member 2
TDRKH tudor and KH domain containing
THBD thrombomodulin
TMEM212 transmembrane protein 212
TOP3A topoisomerase (DNA) III alpha
TRD T cell receptor delta locus
TRIM45 tripartite motif containing 45
TSPAN9 tetraspanin 9
TXNL4A thioredoxin-like 4A
USP46 ubiquitin specific peptidase 46

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABHD17B abhydrolase domain containing 17B
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD36 ankyrin repeat domain 36
ARHGAP11A Rho GTPase activating protein 11A
ASCC2 activating signal cointegrator 1 complex subunit 2
ATF7IP2 activating transcription factor 7 interacting protein 2
BACE1 beta-site APP-cleaving enzyme 1
BTF3P12 basic transcription factor 3 pseudogene 12
C19ORF40 chromosome 19 open reading frame 40
C1ORF115 chromosome 1 open reading frame 115
C5ORF45 chromosome 5 open reading frame 45
C7ORF43 chromosome 7 open reading frame 43
C9ORF91 chromosome 9 open reading frame 91
CAPN15 calpain 15
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDKL3 cyclin-dependent kinase-like 3
CGA glycoprotein hormones, alpha polypeptide
CHML choroideremia-like (Rab escort protein 2)
CLDN15 claudin 15
CTNNBIP1 catenin, beta interacting protein 1
DDIT3 DNA-damage-inducible transcript 3
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EVPL envoplakin
FLT4 fms-related tyrosine kinase 4
HIST1H1D histone cluster 1, H1d
HIST1H2BF histone cluster 1, H2bf
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IGFBP6 insulin-like growth factor binding protein 6
INCENP inner centromere protein antigens 135/155kDa
IRAK4 interleukin-1 receptor-associated kinase 4
IRF2BP1 interferon regulatory factor 2 binding protein 1
ISG15 ISG15 ubiquitin-like modifier
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIFAP3 kinesin-associated protein 3
KLF7 Kruppel-like factor 7 (ubiquitous)
LIG4 ligase IV, DNA, ATP-dependent
LOC730101 uncharacterized LOC730101
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MANBA mannosidase, beta A, lysosomal
MAST3 microtubule associated serine/threonine kinase 3
MBTD1 mbt domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCOLN3 mucolipin 3
MFSD11 major facilitator superfamily domain containing 11
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MUL1 mitochondrial E3 ubiquitin protein ligase 1
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NT5C 5', 3'-nucleotidase, cytosolic
P3H1 prolyl 3-hydroxylase 1
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PDZRN3 PDZ domain containing ring finger 3
PELP1 proline, glutamate and leucine rich protein 1
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLA2G15 phospholipase A2, group XV
PLEKHO1 pleckstrin homology domain containing, family O member 1
PPT2 palmitoyl-protein thioesterase 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAB28 RAB28, member RAS oncogene family
RAB4B RAB4B, member RAS oncogene family
RBM38 RNA binding motif protein 38
RFTN1 raftlin, lipid raft linker 1
RNF25 ring finger protein 25
RNF31 ring finger protein 31
RPAP2 RNA polymerase II associated protein 2
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SETD8 SET domain containing (lysine methyltransferase) 8
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SNIP1 Smad nuclear interacting protein 1
SOX12 SRY (sex determining region Y)-box 12
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TARP TCR gamma alternate reading frame protein
TLN1 talin 1
TMEM121 transmembrane protein 121
TMEM183A transmembrane protein 183A
TPRA1 transmembrane protein, adipocyte asscociated 1
TRAF2 TNF receptor-associated factor 2
TRAPPC13 trafficking protein particle complex 13
TRIM25 tripartite motif containing 25
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSPAN1 tetraspanin 1
UBQLN4 ubiquilin 4
USP36 ubiquitin specific peptidase 36
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
ZFHX3 zinc finger homeobox 3
ZNF141 zinc finger protein 141
ZNF205 zinc finger protein 205
ZNF675 zinc finger protein 675
ZNF770 zinc finger protein 770
ZNF778 zinc finger protein 778