metacycline-4143 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the metacycline-4143 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
AHSP alpha hemoglobin stabilizing protein
AQP6 aquaporin 6, kidney specific
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CARTPT CART prepropeptide
CCL19 chemokine (C-C motif) ligand 19
CDK2 cyclin-dependent kinase 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLCA2 chloride channel accessory 2
CLDN17 claudin 17
COL10A1 collagen, type X, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL7A1 collagen, type VII, alpha 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CTIF CBP80/20-dependent translation initiation factor
CXCR2 chemokine (C-X-C motif) receptor 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22
DENND6B DENN/MADD domain containing 6B
DKFZP434L187 uncharacterized LOC26082
DMPK dystrophia myotonica-protein kinase
DVL2 dishevelled segment polarity protein 2
ELP6 elongator acetyltransferase complex subunit 6
ERC2-IT1 ERC2 intronic transcript 1
FAM134B family with sequence similarity 134, member B
FGF1 fibroblast growth factor 1 (acidic)
FGF14 fibroblast growth factor 14
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOXE1 forkhead box E1
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GFER growth factor, augmenter of liver regeneration
GFI1B growth factor independent 1B transcription repressor
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GP2 glycoprotein 2 (zymogen granule membrane)
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRK5 G protein-coupled receptor kinase 5
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
IFNA10 interferon, alpha 10
IFNA5 interferon, alpha 5
IMPG1 interphotoreceptor matrix proteoglycan 1
INSL3 insulin-like 3 (Leydig cell)
IRF8 interferon regulatory factor 8
KANK1 KN motif and ankyrin repeat domains 1
KDM4B lysine (K)-specific demethylase 4B
KLF13 Kruppel-like factor 13
KRT23 keratin 23, type I
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LINC00216 long intergenic non-protein coding RNA 216
MAGEA8 melanoma antigen family A8
MCAM melanoma cell adhesion molecule
MECOM MDS1 and EVI1 complex locus
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTSS1 metastasis suppressor 1
MX1 MX dynamin-like GTPase 1
NLRP3 NLR family, pyrin domain containing 3
NR6A1 nuclear receptor subfamily 6, group A, member 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
OR2W1 olfactory receptor, family 2, subfamily W, member 1
PAH phenylalanine hydroxylase
PDLIM4 PDZ and LIM domain 4
PILRA paired immunoglobin-like type 2 receptor alpha
PPP1R17 protein phosphatase 1, regulatory subunit 17
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPRB protein tyrosine phosphatase, receptor type, B
RAB40C RAB40C, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RORA RAR-related orphan receptor A
SATB2 SATB homeobox 2
SCNN1B sodium channel, non voltage gated 1 beta subunit
SEZ6L seizure related 6 homolog (mouse)-like
SH2D3A SH2 domain containing 3A
SIPA1 signal-induced proliferation-associated 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SOD2 superoxide dismutase 2, mitochondrial
SYN2 synapsin II
TDRD12 tudor domain containing 12
TEX13A testis expressed 13A
TRIM29 tripartite motif containing 29
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSC22D2 TSC22 domain family, member 2
TTC22 tetratricopeptide repeat domain 22
TULP2 tubby like protein 2
UPK1A uroplakin 1A
USP22 ubiquitin specific peptidase 22
WNT2B wingless-type MMTV integration site family, member 2B
ZER1 zyg-11 related, cell cycle regulator
ZFPL1 zinc finger protein-like 1
ZNF44 zinc finger protein 44
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTL8 actin-like 8
ADGRG2 adhesion G protein-coupled receptor G2
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BRAF B-Raf proto-oncogene, serine/threonine kinase
C17ORF53 chromosome 17 open reading frame 53
C2ORF27A chromosome 2 open reading frame 27A
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMK4 calcium/calmodulin-dependent protein kinase IV
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CES3 carboxylesterase 3
CGA glycoprotein hormones, alpha polypeptide
CHKB choline kinase beta
CRIP1 cysteine-rich protein 1 (intestinal)
CRYBB2P1 crystallin, beta B2 pseudogene 1
CUEDC1 CUE domain containing 1
DBF4B DBF4 zinc finger B
DCAF4 DDB1 and CUL4 associated factor 4
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
ERN2 endoplasmic reticulum to nucleus signaling 2
FADS2 fatty acid desaturase 2
FAM46C family with sequence similarity 46, member C
FBXO2 F-box protein 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FURIN furin (paired basic amino acid cleaving enzyme)
GADD45G growth arrest and DNA-damage-inducible, gamma
GAMT guanidinoacetate N-methyltransferase
GFI1 growth factor independent 1 transcription repressor
HCAR3 hydroxycarboxylic acid receptor 3
HDAC11 histone deacetylase 11
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXB2 homeobox B2
HPN hepsin
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KDM7A lysine (K)-specific demethylase 7A
KLF3 Kruppel-like factor 3 (basic)
KLHL28 kelch-like family member 28
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRRC20 leucine rich repeat containing 20
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP7D1 MAP7 domain containing 1
MEFV Mediterranean fever
MFSD11 major facilitator superfamily domain containing 11
MOB3B MOB kinase activator 3B
MRPL41 mitochondrial ribosomal protein L41
MTCP1 mature T-cell proliferation 1
MTG1 mitochondrial ribosome-associated GTPase 1
MXD3 MAX dimerization protein 3
NBEAL2 neurobeachin-like 2
NDOR1 NADPH dependent diflavin oxidoreductase 1
NIPAL2 NIPA-like domain containing 2
NKX3-2 NK3 homeobox 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OLFML2A olfactomedin-like 2A
PARPBP PARP1 binding protein
PCDHB13 protocadherin beta 13
PCDHB3 protocadherin beta 3
PCDHB8 protocadherin beta 8
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G3 phospholipase A2, group III
POMT2 protein-O-mannosyltransferase 2
PRKCE protein kinase C, epsilon
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RHBG Rh family, B glycoprotein (gene/pseudogene)
RPAP1 RNA polymerase II associated protein 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC16A6 solute carrier family 16, member 6
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM121 transmembrane protein 121
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPAN1 tetraspanin 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBTB6 zinc finger and BTB domain containing 6
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF37BP zinc finger protein 37B, pseudogene
ZNF701 zinc finger protein 701
ZNF747 zinc finger protein 747
ZNF750 zinc finger protein 750
ZNF787 zinc finger protein 787
ZSWIM1 zinc finger, SWIM-type containing 1