metacycline-2901 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the metacycline-2901 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADORA1 adenosine A1 receptor
AFF2 AF4/FMR2 family, member 2
AGFG1 ArfGAP with FG repeats 1
AIM1L absent in melanoma 1-like
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOE apolipoprotein E
AREG amphiregulin
ATAT1 alpha tubulin acetyltransferase 1
ATP10B ATPase, class V, type 10B
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BSPRY B-box and SPRY domain containing
C1ORF105 chromosome 1 open reading frame 105
CDH8 cadherin 8, type 2
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLTA clathrin, light chain A
CNTD2 cyclin N-terminal domain containing 2
CPN2 carboxypeptidase N, polypeptide 2
CREBZF CREB/ATF bZIP transcription factor
CRHR2 corticotropin releasing hormone receptor 2
CRYGC crystallin, gamma C
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CYB561 cytochrome b561
CYHR1 cysteine/histidine-rich 1
DICER1 dicer 1, ribonuclease type III
EFNA4 ephrin-A4
EFR3B EFR3 homolog B (S. cerevisiae)
EGFR epidermal growth factor receptor
EMID1 EMI domain containing 1
EXPH5 exophilin 5
FLT4 fms-related tyrosine kinase 4
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FUT2 fucosyltransferase 2 (secretor status included)
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GIF gastric intrinsic factor (vitamin B synthesis)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPR153 G protein-coupled receptor 153
GRIP2 glutamate receptor interacting protein 2
GYPB glycophorin B (MNS blood group)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXB9 homeobox B9
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
IL11 interleukin 11
IL27RA interleukin 27 receptor, alpha
INA internexin neuronal intermediate filament protein, alpha
IQCE IQ motif containing E
IRF5 interferon regulatory factor 5
KANK1 KN motif and ankyrin repeat domains 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF16B kinesin family member 16B
KLHL28 kelch-like family member 28
KLHL3 kelch-like family member 3
KRTAP5-8 keratin associated protein 5-8
LAMB3 laminin, beta 3
LATS1 large tumor suppressor kinase 1
LMF1 lipase maturation factor 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MFSD6 major facilitator superfamily domain containing 6
MYL10 myosin, light chain 10, regulatory
MYO9B myosin IXB
NANOG Nanog homeobox
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPFFR1 neuropeptide FF receptor 1
OGFR opioid growth factor receptor
PML promyelocytic leukemia
POFUT1 protein O-fucosyltransferase 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAP1GAP RAP1 GTPase activating protein
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RPL7 ribosomal protein L7
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RUFY3 RUN and FYVE domain containing 3
S100A13 S100 calcium binding protein A13
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SFTPB surfactant protein B
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPHK1 sphingosine kinase 1
STS steroid sulfatase (microsomal), isozyme S
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TCAF1 TRPM8 channel-associated factor 1
TLN2 talin 2
TMEM176A transmembrane protein 176A
TMEM63A transmembrane protein 63A
TOP3B topoisomerase (DNA) III beta
TRAF4 TNF receptor-associated factor 4
TTC38 tetratricopeptide repeat domain 38
USP53 ubiquitin specific peptidase 53
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ABHD4 abhydrolase domain containing 4
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARID5A AT rich interactive domain 5A (MRF1-like)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAHD1 bromo adjacent homology domain containing 1
BAK1 BCL2-antagonist/killer 1
BIRC3 baculoviral IAP repeat containing 3
BPI bactericidal/permeability-increasing protein
C2CD2 C2 calcium-dependent domain containing 2
C5 complement component 5
C7ORF43 chromosome 7 open reading frame 43
CBX7 chromobox homolog 7
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCL2 chemokine (C-C motif) ligand 2
CD300C CD300c molecule
CDK6 cyclin-dependent kinase 6
CHMP7 charged multivesicular body protein 7
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
DENND4C DENN/MADD domain containing 4C
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNMBP dynamin binding protein
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGR2 early growth response 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM188A family with sequence similarity 188, member A
FAM53B family with sequence similarity 53, member B
FES FES proto-oncogene, tyrosine kinase
GID4 GID complex subunit 4
GSTZ1 glutathione S-transferase zeta 1
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HIST1H4D histone cluster 1, H4d
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA5 homeobox A5
HP haptoglobin
HPSE heparanase
HYAL2 hyaluronoglucosaminidase 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IQCG IQ motif containing G
ISG15 ISG15 ubiquitin-like modifier
ITGA10 integrin, alpha 10
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCTD15 potassium channel tetramerization domain containing 15
LOC729164 hCG1732469
LPAR6 lysophosphatidic acid receptor 6
LRRK1 leucine-rich repeat kinase 1
MRPL44 mitochondrial ribosomal protein L44
MYH15 myosin, heavy chain 15
NABP2 nucleic acid binding protein 2
NFE2L3 nuclear factor, erythroid 2-like 3
NOL10 nucleolar protein 10
NOL6 nucleolar protein 6 (RNA-associated)
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NTSR1 neurotensin receptor 1 (high affinity)
PARP12 poly (ADP-ribose) polymerase family, member 12
PARP16 poly (ADP-ribose) polymerase family, member 16
PDGFD platelet derived growth factor D
PIR pirin (iron-binding nuclear protein)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POM121 POM121 transmembrane nucleoporin
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
POR P450 (cytochrome) oxidoreductase
PRICKLE3 prickle homolog 3 (Drosophila)
PTCD1 pentatricopeptide repeat domain 1
PYGB phosphorylase, glycogen; brain
RAB23 RAB23, member RAS oncogene family
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RPAP1 RNA polymerase II associated protein 1
RSAD1 radical S-adenosyl methionine domain containing 1
SEC31B SEC31 homolog B (S. cerevisiae)
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPON2 spondin 2, extracellular matrix protein
STK11 serine/threonine kinase 11
STX1A syntaxin 1A (brain)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TBC1D17 TBC1 domain family, member 17
TESK1 testis-specific kinase 1
THBS3 thrombospondin 3
THEM6 thioesterase superfamily member 6
TKFC triokinase/FMN cyclase
TPCN1 two pore segment channel 1
TRABD TraB domain containing
TRIM5 tripartite motif containing 5
TRPS1 trichorhinophalangeal syndrome I
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
ZNF428 zinc finger protein 428
ZNF816 zinc finger protein 816