metabolic acidosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A lactic acidosis that has_material_basis_in high levels of acid. (Human Disease Ontology, DOID_0050758)
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Genes

259 genes co-occuring with the disease metabolic acidosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
GLS glutaminase 2.16289
GLS2 glutaminase 2 (liver, mitochondrial) 1.98947
LBR lamin B receptor 1.84181
RHCG Rh family, C glycoprotein 1.73732
PTH parathyroid hormone 1.68091
RHBG Rh family, B glycoprotein (gene/pseudogene) 1.64711
ALB albumin 1.61799
DNAH8 dynein, axonemal, heavy chain 8 1.60189
INS insulin 1.54672
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 1.53524
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 1.46363
GSS glutathione synthetase 1.44386
DMRTA1 DMRT-like family A1 1.42762
SCNN1G sodium channel, non voltage gated 1 gamma subunit 1.4206
OPLAH 5-oxoprolinase (ATP-hydrolysing) 1.41183
REN renin 1.37512
WNK4 WNK lysine deficient protein kinase 4 1.3712
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 1.3494
PC pyruvate carboxylase 1.34025
CA2 carbonic anhydrase II 1.31974
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 1.29615
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.27563
MGAM maltase-glucoamylase 1.25733
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 1.20439
IGF1 insulin-like growth factor 1 (somatomedin C) 1.18927
WNK1 WNK lysine deficient protein kinase 1 1.17636
GPR4 G protein-coupled receptor 4 1.14942
MLYCD malonyl-CoA decarboxylase 1.13289
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.11225
GCG glucagon 1.10343
ALPPL2 alkaline phosphatase, placental-like 2 1.09209
ALPP alkaline phosphatase, placental 1.09167
ALPL alkaline phosphatase, liver/bone/kidney 1.09083
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 1.07824
MMD monocyte to macrophage differentiation-associated 1.07152
GLUL glutamate-ammonia ligase 1.07068
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 1.07026
FBP1 fructose-1,6-bisphosphatase 1 1.0606
OSGEP O-sialoglycoprotein endopeptidase 1.03367
SLC26A4 solute carrier family 26 (anion exchanger), member 4 1.01891
KLHL3 kelch-like family member 3 0.990222
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.97002
PCCB propionyl CoA carboxylase, beta polypeptide 0.95745
MUT methylmalonyl CoA mutase 0.947435
AQP2 aquaporin 2 (collecting duct) 0.942443
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.927932
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 0.925039
MB myoglobin 0.915963
DMBT1 deleted in malignant brain tumors 1 0.912668
F2 coagulation factor II (thrombin) 0.90321
ACAT1 acetyl-CoA acetyltransferase 1 0.902389
IVD isovaleryl-CoA dehydrogenase 0.895
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.88393
RHCE Rh blood group, CcEe antigens 0.881472
GPR68 G protein-coupled receptor 68 0.875329
BGLAP bone gamma-carboxyglutamate (gla) protein 0.868368
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.852402
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 0.844211
CSN1S1 casein alpha s1 0.841753
CUL3 cullin 3 0.816745
A1BG alpha-1-B glycoprotein 0.805667
BTD biotinidase 0.788852
SDS serine dehydratase 0.774523
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.77207
CA4 carbonic anhydrase IV 0.768393
POMC proopiomelanocortin 0.763494
DLD dihydrolipoamide dehydrogenase 0.74883
RHD Rh blood group, D antigen 0.746391
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.743547
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.737865
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.721673
TNF tumor necrosis factor 0.717635
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.711183
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.707157
SCNN1B sodium channel, non voltage gated 1 beta subunit 0.703536
ACAA2 acetyl-CoA acyltransferase 2 0.703134
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 0.703134
ATP11A ATPase, class VI, type 11A 0.695905
ACE angiotensin I converting enzyme 0.692697
B2M beta-2-microglobulin 0.683892
F3 coagulation factor III (thromboplastin, tissue factor) 0.675909
SLC38A2 solute carrier family 38, member 2 0.66755
ACSF3 acyl-CoA synthetase family member 3 0.66755
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 0.661594
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 0.651694
PHGDH phosphoglycerate dehydrogenase 0.645375
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 0.631205
PKDCC protein kinase domain containing, cytoplasmic 0.6214
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 0.620617
CRYZ crystallin, zeta (quinone reductase) 0.613183
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type 0.608885
PFKM phosphofructokinase, muscle 0.608104
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 0.592506
SMOX spermine oxidase 0.591727
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.583163
PECR peroxisomal trans-2-enoyl-CoA reductase 0.576939
ACO2 aconitase 2, mitochondrial 0.571495
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 0.571107
CA1 carbonic anhydrase I 0.571107
SLC16A6 solute carrier family 16, member 6 0.563723
VPS33B vacuolar protein sorting 33 homolog B (yeast) 0.557509
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.553627
CRP C-reactive protein, pentraxin-related 0.550911
MCEE methylmalonyl CoA epimerase 0.548971
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.537344
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.528835
ZMYM4 zinc finger, MYM-type 4 0.523045
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 0.521502
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.515725
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.51534
MLX MLX, MAX dimerization protein 0.508424
PAOX polyamine oxidase (exo-N4-amino) 0.508424
ETFDH electron-transferring-flavoprotein dehydrogenase 0.505739
GGT1 gamma-glutamyltransferase 1 0.505739
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 0.500379
ASIC1 acid sensing (proton gated) ion channel 1 0.498467
CALCA calcitonin-related polypeptide alpha 0.497703
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.49274
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 0.484744
MSTN myostatin 0.483224
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 0.482084
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.482084
MYH4 myosin, heavy chain 4, skeletal muscle 0.477909
IMMT inner membrane protein, mitochondrial 0.469576
ACAA1 acetyl-CoA acyltransferase 1 0.463527
IL6 interleukin 6 0.458996
AVP arginine vasopressin 0.452962
METTL13 methyltransferase like 13 0.450324
IGLV1-36 immunoglobulin lambda variable 1-36 0.443923
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.436778
FGF23 fibroblast growth factor 23 0.433397
RRBP1 ribosome binding protein 1 0.430768
SLC26A7 solute carrier family 26 (anion exchanger), member 7 0.427015
STX8 syntaxin 8 0.421765
MDH1 malate dehydrogenase 1, NAD (soluble) 0.421765
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.42139
OCRL oculocerebrorenal syndrome of Lowe 0.418019
CALB1 calbindin 1, 28kDa 0.414276
DCPS decapping enzyme, scavenger 0.40904
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.406051
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.403811
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 0.401199
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.400453
CLCN5 chloride channel, voltage-sensitive 5 0.398962
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.398216
VIP vasoactive intestinal peptide 0.397471
MGP matrix Gla protein 0.39598
UBE2H ubiquitin-conjugating enzyme E2H 0.395235
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.390025
KNTC1 kinetochore associated 1 0.385936
KRT38 keratin 38, type I 0.384451
GK glycerol kinase 0.382223
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 0.372587
DLL1 delta-like 1 (Drosophila) 0.370737
TRPV5 transient receptor potential cation channel, subfamily V, member 5 0.368888
IGFBP3 insulin-like growth factor binding protein 3 0.367779
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 0.366671
ACLY ATP citrate lyase 0.364824
OR5K2 olfactory receptor, family 5, subfamily K, member 2 0.362609
CLDN15 claudin 15 0.357446
MAMLD1 mastermind-like domain containing 1 0.355604
WT1 Wilms tumor 1 0.353763
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial 0.346409
TALDO1 transaldolase 1 0.34384
G6PC glucose-6-phosphatase, catalytic subunit 0.342006
HK1 hexokinase 1 0.340173
GHR growth hormone receptor 0.334681
CD320 CD320 molecule 0.334315
GUSB glucuronidase, beta 0.329565
IGLV3-9 immunoglobulin lambda variable 3-9 (gene/pseudogene) 0.328469
AMY2A amylase, alpha 2A (pancreatic) 0.326281
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 0.325552
SLC30A3 solute carrier family 30 (zinc transporter), member 3 0.317545
SLC38A5 solute carrier family 38, member 5 0.315729
ELAVL1 ELAV like RNA binding protein 1 0.315366
CTSS cathepsin S 0.315003
CASS4 Cas scaffolding protein family member 4 0.314278
KNG1 kininogen 1 0.313552
CP ceruloplasmin (ferroxidase) 0.313552
HLA-DOB major histocompatibility complex, class II, DO beta 0.309204
HAO2 hydroxyacid oxidase 2 (long chain) 0.304142
ACTG1 actin gamma 1 0.301615
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 0.300173
AMPD2 adenosine monophosphate deaminase 2 0.299812
GPS2 G protein pathway suppressor 2 0.299452
AMPD3 adenosine monophosphate deaminase 3 0.298011
RYR1 ryanodine receptor 1 (skeletal) 0.291898
FSIP1 fibrous sheath interacting protein 1 0.290103
GABPB1 GA binding protein transcription factor, beta subunit 1 0.279724
CNOT8 CCR4-NOT transcription complex, subunit 8 0.273308
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.272953
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.263368
AKAP5 A kinase (PRKA) anchor protein 5 0.26266
FOS FBJ murine osteosarcoma viral oncogene homolog 0.261952
CAT catalase 0.260538
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 0.259124
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 0.257005
EDN1 endothelin 1 0.256652
DEFB104B defensin, beta 104B 0.253479
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.25207
GLRA1 glycine receptor, alpha 1 0.249608
LARS leucyl-tRNA synthetase 0.247852
ELOVL2 ELOVL fatty acid elongase 2 0.243645
PCCA propionyl CoA carboxylase, alpha polypeptide 0.242245
ACTB actin, beta 0.241546
CLDN14 claudin 14 0.240847
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.23666
SOD2 superoxide dismutase 2, mitochondrial 0.235964
SPP1 secreted phosphoprotein 1 0.235268
TF transferrin 0.232836
LATS2 large tumor suppressor kinase 2 0.232489
PYGB phosphorylase, glycogen; brain 0.226607
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.225573
PYGL phosphorylase, glycogen, liver 0.223509
FABP6 fatty acid binding protein 6, ileal 0.223509
HGD homogentisate 1,2-dioxygenase 0.220766
CIRBP cold inducible RNA binding protein 0.220766
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.217352
HES3 hes family bHLH transcription factor 3 0.216672
PTOV1 prostate tumor overexpressed 1 0.212608
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.212271
ADM adrenomedullin 0.211597
GIN1 gypsy retrotransposon integrase 1 0.211261
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 0.211261
TBXA2R thromboxane A2 receptor 0.209918
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.208914
NPPA natriuretic peptide A 0.207578
GPI glucose-6-phosphate isomerase 0.202946
BMP7 bone morphogenetic protein 7 0.201962
LRRC4C leucine rich repeat containing 4C 0.201308
PYGM phosphorylase, glycogen, muscle 0.200331
GAST gastrin 0.198386
LEP leptin 0.195501
CLDN3 claudin 3 0.193915
EDNRB endothelin receptor type B 0.189244
GSTZ1 glutathione S-transferase zeta 1 0.187719
COQ9 coenzyme Q9 0.185313
DUOXA1 dual oxidase maturation factor 1 0.185313
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.182375
CLDN8 claudin 8 0.179802
HPD 4-hydroxyphenylpyruvate dioxygenase 0.178682
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.178682
TRH thyrotropin-releasing hormone 0.177851
AQP3 aquaporin 3 (Gill blood group) 0.176757
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.176215
FXYD3 FXYD domain containing ion transport regulator 3 0.173057
TCEA1 transcription elongation factor A (SII), 1 0.172799
TTR transthyretin 0.172038
AOX1 aldehyde oxidase 1 0.171785
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 0.168381
LCT lactase 0.167915
NOTO notochord homeobox 0.167224
GGCT gamma-glutamylcyclotransferase 0.166995
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 0.164786
CYGB cytoglobin 0.164359
CRNN cornulin 0.162707
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.162505
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 0.161139
C6ORF25 chromosome 6 open reading frame 25 0.158951