mesothelioma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A usually malignant and aggressive neoplasm of the mesothelium which is often associated with exposure to asbestos.|A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed) (Experimental Factor Ontology, EFO_0000588)
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Genes

209 genes co-occuring with the biological term mesothelioma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
ACVR1 activin A receptor, type I
ADIPOQ adiponectin, C1Q and collagen domain containing
AHNAK AHNAK nucleoprotein
AJUBA ajuba LIM protein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALK anaplastic lymphoma receptor tyrosine kinase
ANGPT1 angiopoietin 1
AQP1 aquaporin 1 (Colton blood group)
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
AURKA aurora kinase A
AURKB aurora kinase B
AVEN apoptosis, caspase activation inhibitor
AXL AXL receptor tyrosine kinase
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CA9 carbonic anhydrase IX
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CADM1 cell adhesion molecule 1
CALB2 calbindin 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBX4 chromobox homolog 4
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFLAR CASP8 and FADD-like apoptosis regulator
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
CLDN1 claudin 1
CLDN4 claudin 4
CLNS1A chloride channel, nucleotide-sensitive, 1A
COBLL1 cordon-bleu WH2 repeat protein-like 1
CREB1 cAMP responsive element binding protein 1
CRTAM cytotoxic and regulatory T cell molecule
CTAG1B cancer/testis antigen 1B
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CUL4A cullin 4A
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DPP4 dipeptidyl-peptidase 4
DVL3 dishevelled segment polarity protein 3
E2F1 E2F transcription factor 1
EBAG9 estrogen receptor binding site associated, antigen, 9
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EGFR epidermal growth factor receptor
EHF ets homologous factor
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELAVL1 ELAV like RNA binding protein 1
EPHB2 EPH receptor B2
EPHB4 EPH receptor B4
EPOR erythropoietin receptor
ERCC1 excision repair cross-complementation group 1
EWSR1 EWS RNA-binding protein 1
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FHIT fragile histidine triad
FOSL1 FOS-like antigen 1
GAS5 growth arrest-specific 5 (non-protein coding)
GMNN geminin, DNA replication inhibitor
GREM1 gremlin 1, DAN family BMP antagonist
GSTM1 glutathione S-transferase mu 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HTRA1 HtrA serine peptidase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITLN1 intelectin 1 (galactofuranose binding)
JUP junction plakoglobin
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT5 keratin 5, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIMS2 LIM and senescent cell antigen-like domains 2
LOXL4 lysyl oxidase-like 4
LTBP1 latent transforming growth factor beta binding protein 1
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MCAM melanoma cell adhesion molecule
MCL1 myeloid cell leukemia 1
MCM7 minichromosome maintenance complex component 7
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR103A1 microRNA 103a-1
MIR126 microRNA 126
MIR145 microRNA 145
MIR16-1 microRNA 16-1
MIR16-2 microRNA 16-2
MIR21 microRNA 21
MIR23A microRNA 23a
MIR34A microRNA 34a
MIR625 microRNA 625
MIR92A1 microRNA 92a-1
MKI67 marker of proliferation Ki-67
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MSLN mesothelin
MSLNL mesothelin-like
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NF2 neurofibromin 2 (merlin)
NKX2-1 NK2 homeobox 1
NTS neurotensin
PARP1 poly (ADP-ribose) polymerase 1
PDGFD platelet derived growth factor D
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPN podoplanin
PDZK1IP1 PDZK1 interacting protein 1
PEA15 phosphoprotein enriched in astrocytes 15
PGF placental growth factor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKM pyruvate kinase, muscle
PLAUR plasminogen activator, urokinase receptor
PLXNA1 plexin A1
POMC proopiomelanocortin
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PRKCD protein kinase C, delta
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PVT1 Pvt1 oncogene (non-protein coding)
RAB25 RAB25, member RAS oncogene family
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
SDC1 syndecan 1
SDK1 sidekick cell adhesion molecule 1
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SFRP4 secreted frizzled-related protein 4
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A4 solute carrier family 16, member 4
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD2 SMAD family member 2
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSTR4 somatostatin receptor 4
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCN2 transcobalamin II
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
THY1 Thy-1 cell surface antigen
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNXB tenascin XB
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP63 tumor protein p63
TPBG trophoblast glycoprotein
TRIP6 thyroid hormone receptor interactor 6
TSC1 tuberous sclerosis 1
TUBB3 tubulin, beta 3 class III
TUSC2 tumor suppressor candidate 2
TWIST1 twist family bHLH transcription factor 1
TXNDC2 thioredoxin domain containing 2 (spermatozoa)
UPK3A uroplakin 3A
VCAN versican
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VIM vimentin
WIF1 WNT inhibitory factor 1
WNT2 wingless-type MMTV integration site family member 2
WT1 Wilms tumor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YAP1 Yes-associated protein 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YY1 YY1 transcription factor
ZEB1 zinc finger E-box binding homeobox 1
ZIC1 Zic family member 1