mesothelioma cell Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description A cell from a tumor derived from mesothelial tissue (peritoneum, pleura, pericardium); both benign and malignant varieties exist. Malignant varieties are often the result of excessive exposure to asbestos. (BRENDA Tissue and Enzyme Source Ontology, BTO_0002423)
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Genes

218 proteins co-occuring with the tissue mesothelioma cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
MSLN mesothelin 1.62108
RPL18A ribosomal protein L18a 1.1758
LRRN4 leucine rich repeat neuronal 4 1.13723
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.09695
NF2 neurofibromin 2 (merlin) 1.08811
TP53 tumor protein p53 1.06426
BCL2L1 BCL2-like 1 1.0462
CDKN2A cyclin-dependent kinase inhibitor 2A 0.985425
ZDHHC8 zinc finger, DHHC-type containing 8 0.92291
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.919061
UPK3B uroplakin 3B 0.900296
AK7 adenylate kinase 7 0.881627
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.849585
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.829034
PUF60 poly-U binding splicing factor 60KDa 0.824013
BIRC5 baculoviral IAP repeat containing 5 0.818158
RAP1A RAP1A, member of RAS oncogene family 0.81565
EGFR epidermal growth factor receptor 0.784388
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 0.769855
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.764468
SP1 Sp1 transcription factor 0.750405
BAX BCL2-associated X protein 0.74174
CALB2 calbindin 2 0.738442
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.723631
TNNT1 troponin T type 1 (skeletal, slow) 0.71542
RBM8A RNA binding motif protein 8A 0.7146
DIO2 deiodinase, iodothyronine, type II 0.703536
MET MET proto-oncogene, receptor tyrosine kinase 0.678617
EIF4E eukaryotic translation initiation factor 4E 0.670064
PDGFD platelet derived growth factor D 0.660304
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.657866
SFRP4 secreted frizzled-related protein 4 0.65746
CCND1 cyclin D1 0.646911
FOSL1 FOS-like antigen 1 0.621024
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.614974
CD46 CD46 molecule, complement regulatory protein 0.59646
SEP15 15 kDa selenoprotein 0.586026
DVL1 dishevelled segment polarity protein 1 0.577215
MDK midkine (neurite growth-promoting factor 2) 0.57042
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.552888
KAT7 K(lysine) acetyltransferase 7 0.551298
SDC1 syndecan 1 0.551298
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.546533
IGHV3-30 immunoglobulin heavy variable 3-30 0.543359
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.532274
CD44 CD44 molecule (Indian blood group) 0.530693
DIRC2 disrupted in renal carcinoma 2 0.529508
PDPN podoplanin 0.529113
XAF1 XIAP associated factor 1 0.527928
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.511384
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.50079
PDGFA platelet-derived growth factor alpha polypeptide 0.499223
HTRA1 HtrA serine peptidase 1 0.496483
CUL4A cullin 4A 0.483206
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.474646
INCENP inner centromere protein antigens 135/155kDa 0.472704
DVL3 dishevelled segment polarity protein 3 0.470375
TXN thioredoxin 0.456828
ARHGAP32 Rho GTPase activating protein 32 0.456055
COPA coatomer protein complex, subunit alpha 0.454126
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.453355
CD9 CD9 molecule 0.450657
LTBP3 latent transforming growth factor beta binding protein 3 0.437972
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.437972
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.430695
LTBP2 latent transforming growth factor beta binding protein 2 0.425344
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.424963
MMP2 matrix metallopeptidase 2 0.423818
AXL AXL receptor tyrosine kinase 0.422673
WT1 Wilms tumor 1 0.420004
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.415434
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.412771
PIAS3 protein inhibitor of activated STAT, 3 0.412391
HAS2 hyaluronan synthase 2 0.409731
HAPLN1 hyaluronan and proteoglycan link protein 1 0.409351
VEGFA vascular endothelial growth factor A 0.40328
SOD2 superoxide dismutase 2, mitochondrial 0.393064
HRK harakiri, BCL2 interacting protein 0.390044
TPBG trophoblast glycoprotein 0.389289
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.38552
METAP2 methionyl aminopeptidase 2 0.382508
FN1 fibronectin 1 0.361901
LTBP1 latent transforming growth factor beta binding protein 1 0.355942
GREM1 gremlin 1, DAN family BMP antagonist 0.354826
HDAC2 histone deacetylase 2 0.354084
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.352969
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.347038
FZD2 frizzled class receptor 2 0.3356
TYMS thymidylate synthetase 0.328628
MTAP methylthioadenosine phosphorylase 0.325335
WNT5A wingless-type MMTV integration site family, member 5A 0.324605
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.324239
FGF2 fibroblast growth factor 2 (basic) 0.314772
FGFR1 fibroblast growth factor receptor 1 0.313683
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.309335
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.307528
GLIS2 GLIS family zinc finger 2 0.306805
WNT3 wingless-type MMTV integration site family, member 3 0.303559
SPHK2 sphingosine kinase 2 0.303198
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.302478
PDPK1 3-phosphoinositide dependent protein kinase 1 0.301039
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.29996
TGFB2 transforming growth factor, beta 2 0.29673
TYRO3 TYRO3 protein tyrosine kinase 0.292436
ZHX2 zinc fingers and homeoboxes 2 0.284607
IGF1R insulin-like growth factor 1 receptor 0.284253
HAT1 histone acetyltransferase 1 0.281423
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.279307
FPGS folylpolyglutamate synthase 0.277197
THBD thrombomodulin 0.274394
HAS3 hyaluronan synthase 3 0.270909
IGLV2-8 immunoglobulin lambda variable 2-8 0.268137
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.2559
TOP2A topoisomerase (DNA) II alpha 170kDa 0.255234
SDC4 syndecan 4 0.25259
JUN jun proto-oncogene 0.249006
PDGFB platelet-derived growth factor beta polypeptide 0.247079
MCAM melanoma cell adhesion molecule 0.246124
JUNB jun B proto-oncogene 0.237513
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.233162
TSPO translocator protein (18kDa) 0.228764
F8 coagulation factor VIII, procoagulant component 0.219707
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.21883
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.217762
ANXA4 annexin A4 0.215534
BDKRB1 bradykinin receptor B1 0.214954
CSF1R colony stimulating factor 1 receptor 0.214388
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.213112
IL3 interleukin 3 0.194587
DPYD dihydropyrimidine dehydrogenase 0.193942
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 0.19217
TNC tenascin C 0.19035
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.188336
CHEK1 checkpoint kinase 1 0.187148
EMD emerin 0.18588
IGFBP4 insulin-like growth factor binding protein 4 0.185738
VIMP VCP-interacting membrane selenoprotein 0.185559
TYMP thymidine phosphorylase 0.184882
MMP9 matrix metallopeptidase 9 0.182276
RAB12 RAB12, member RAS oncogene family 0.180672
RECQL5 RecQ protein-like 5 0.179455
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.178946
PRPF19 pre-mRNA processing factor 19 0.178285
SIRT1 sirtuin 1 0.17781
RRM1 ribonucleotide reductase M1 0.177272
WIF1 WNT inhibitory factor 1 0.177109
FGFR2 fibroblast growth factor receptor 2 0.17592
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.175742
SCNN1D sodium channel, non voltage gated 1 delta subunit 0.175234
SECISBP2 SECIS binding protein 2 0.174651
RET ret proto-oncogene 0.174084
SPARCL1 SPARC-like 1 (hevin) 0.173765
IRS1 insulin receptor substrate 1 0.172871
AHNAK AHNAK nucleoprotein 0.172482
TGFBI transforming growth factor, beta-induced, 68kDa 0.172417
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 0.171996
FOLR1 folate receptor 1 (adult) 0.171473
IFNA1 interferon, alpha 1 0.1706
BST1 bone marrow stromal cell antigen 1 0.17038
DHDH dihydrodiol dehydrogenase (dimeric) 0.170207
HMBS hydroxymethylbilane synthase 0.170035
CLMP CXADR-like membrane protein 0.168425
PRCP prolylcarboxypeptidase (angiotensinase C) 0.167879
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 0.167145
IL32 interleukin 32 0.166972
ZEB2 zinc finger E-box binding homeobox 2 0.166972
IGFBP3 insulin-like growth factor binding protein 3 0.166326
IFNGR1 interferon gamma receptor 1 0.166177
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.165969
CCNH cyclin H 0.164565
ERCC1 excision repair cross-complementation group 1 0.164438
NTSR1 neurotensin receptor 1 (high affinity) 0.163618
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.163484
MAPK7 mitogen-activated protein kinase 7 0.163382
EEF1A1P6 eukaryotic translation elongation factor 1 alpha 1 pseudogene 6 0.16328
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.163246
PARP1 poly (ADP-ribose) polymerase 1 0.162839
DPP4 dipeptidyl-peptidase 4 0.162631
MCL1 myeloid cell leukemia 1 0.161497
RIPK2 receptor-interacting serine-threonine kinase 2 0.161425
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.160952
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.160728
DHFR dihydrofolate reductase 0.159745
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.159707
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.159437
YAP1 Yes-associated protein 1 0.159087
SLC46A1 solute carrier family 46 (folate transporter), member 1 0.15857
MAPK9 mitogen-activated protein kinase 9 0.157309
PRDX5 peroxiredoxin 5 0.15638
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 0.155207
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.154849
NLRP3 NLR family, pyrin domain containing 3 0.153992
C19ORF48 chromosome 19 open reading frame 48 0.153946
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.153621
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.153018
ZEB1 zinc finger E-box binding homeobox 1 0.152591
CDC6 cell division cycle 6 0.151533
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.151385
GABARAP GABA(A) receptor-associated protein 0.151139
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.150893
CHEK2 checkpoint kinase 2 0.150497
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.149889
CCND3 cyclin D3 0.146245
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.145969
PLG plasminogen 0.145474
FANCD2 Fanconi anemia, complementation group D2 0.144738
HMOX1 heme oxygenase 1 0.144173
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.144173
S100A4 S100 calcium binding protein A4 0.144173
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.143594
IL4R interleukin 4 receptor 0.143187
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.142128
F3 coagulation factor III (thromboplastin, tissue factor) 0.142068
NT5C 5', 3'-nucleotidase, cytosolic 0.141174
IL6 interleukin 6 0.14099
GJA4 gap junction protein, alpha 4, 37kDa 0.137109
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.134949
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.134411