mesoridazine-7256 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the mesoridazine-7256 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADARB1 adenosine deaminase, RNA-specific, B1
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AKTIP AKT interacting protein
AP1M2 adaptor-related protein complex 1, mu 2 subunit
ATAD2B ATPase family, AAA domain containing 2B
ATXN3 ataxin 3
BAIAP2 BAI1-associated protein 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BRCA2 breast cancer 2, early onset
BRD4 bromodomain containing 4
C1ORF35 chromosome 1 open reading frame 35
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CEP104 centrosomal protein 104kDa
CEP162 centrosomal protein 162kDa
CEP290 centrosomal protein 290kDa
CES2 carboxylesterase 2
CLIP4 CAP-GLY domain containing linker protein family, member 4
COPE coatomer protein complex, subunit epsilon
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
DPYSL3 dihydropyrimidinase-like 3
ERCC1 excision repair cross-complementation group 1
FADS3 fatty acid desaturase 3
FAM13A family with sequence similarity 13, member A
FBN2 fibrillin 2
FLJ11292
FOXJ3 forkhead box J3
FZD3 frizzled class receptor 3
GABARAPL1 GABA(A) receptor-associated protein like 1
GLS glutaminase
GPC3 glypican 3
GPR17 G protein-coupled receptor 17
GTF2I general transcription factor IIi
ING1 inhibitor of growth family, member 1
INO80B INO80 complex subunit B
KIAA1644 KIAA1644
KIF2A kinesin heavy chain member 2A
KLHDC3 kelch domain containing 3
LSR lipolysis stimulated lipoprotein receptor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MXD4 MAX dimerization protein 4
NARFL nuclear prelamin A recognition factor-like
NCKAP1 NCK-associated protein 1
NCKIPSD NCK interacting protein with SH3 domain
NF1 neurofibromin 1
NFYA nuclear transcription factor Y, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRXN3 neurexin 3
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PACS1 phosphofurin acidic cluster sorting protein 1
PCM1 pericentriolar material 1
PER1 period circadian clock 1
PLK3 polo-like kinase 3
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP1R9A protein phosphatase 1, regulatory subunit 9A
RAB3A RAB3A, member RAS oncogene family
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RRP1B ribosomal RNA processing 1B
RUNX1-IT1 RUNX1 intronic transcript 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCN11A sodium channel, voltage gated, type XI alpha subunit
SETBP1 SET binding protein 1
SFT2D2 SFT2 domain containing 2
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMAD5 SMAD family member 5
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMYD2 SET and MYND domain containing 2
SPATA2L spermatogenesis associated 2-like
SRPX2 sushi-repeat containing protein, X-linked 2
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STC1 stanniocalcin 1
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBC1D5 TBC1 domain family, member 5
TESK2 testis-specific kinase 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGOLN2 trans-golgi network protein 2
TK2 thymidine kinase 2, mitochondrial
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNNI3 troponin I type 3 (cardiac)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM3 tripartite motif containing 3
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSC22D2 TSC22 domain family, member 2
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
USP24 ubiquitin specific peptidase 24
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZBTB7A zinc finger and BTB domain containing 7A
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF174 zinc finger protein 174
ZNF510 zinc finger protein 510

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ALPK1 alpha-kinase 1
ANXA2P3 annexin A2 pseudogene 3
APH1B APH1B gamma secretase subunit
BAK1 BCL2-antagonist/killer 1
BRD9 bromodomain containing 9
CARD8 caspase recruitment domain family, member 8
CCNA1 cyclin A1
CCNO cyclin O
CCNT1 cyclin T1
CD70 CD70 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHKB choline kinase beta
CIR1 corepressor interacting with RBPJ, 1
CLCF1 cardiotrophin-like cytokine factor 1
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COQ3 coenzyme Q3 methyltransferase
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRYBB2P1 crystallin, beta B2 pseudogene 1
CUL9 cullin 9
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DBF4B DBF4 zinc finger B
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DLL3 delta-like 3 (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EN1 engrailed homeobox 1
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM53B family with sequence similarity 53, member B
FLRT3 fibronectin leucine rich transmembrane protein 3
GAB2 GRB2-associated binding protein 2
GAMT guanidinoacetate N-methyltransferase
HINFP histone H4 transcription factor
HIST1H3B histone cluster 1, H3b
HMG20A high mobility group 20A
INF2 inverted formin, FH2 and WH2 domain containing
IREB2 iron-responsive element binding protein 2
IRF9 interferon regulatory factor 9
JUNB jun B proto-oncogene
KIAA0556 KIAA0556
KIF20A kinesin family member 20A
LPAR3 lysophosphatidic acid receptor 3
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MPP1 membrane protein, palmitoylated 1, 55kDa
MTRF1 mitochondrial translational release factor 1
MUC3B mucin 3B, cell surface associated
MUTYH mutY homolog
MYO1D myosin ID
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NPR3 natriuretic peptide receptor 3
NR1H2 nuclear receptor subfamily 1, group H, member 2
ORAI3 ORAI calcium release-activated calcium modulator 3
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PARD6A par-6 family cell polarity regulator alpha
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLCD1 phospholipase C, delta 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPT2 palmitoyl-protein thioesterase 2
PRICKLE3 prickle homolog 3 (Drosophila)
PRMT7 protein arginine methyltransferase 7
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SLC12A8 solute carrier family 12, member 8
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNIP1 Smad nuclear interacting protein 1
SNTA1 syntrophin, alpha 1
SORBS3 sorbin and SH3 domain containing 3
STK25 serine/threonine kinase 25
STXBP2 syntaxin binding protein 2
SYTL2 synaptotagmin-like 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAGLN3 transgelin 3
TCTN2 tectonic family member 2
TESPA1 thymocyte expressed, positive selection associated 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNRC6B trinucleotide repeat containing 6B
TRAIP TRAF interacting protein
TRAPPC6A trafficking protein particle complex 6A
TRIM66 tripartite motif containing 66
TRIOBP TRIO and F-actin binding protein
TUBA3D tubulin, alpha 3d
TYK2 tyrosine kinase 2
USP27X ubiquitin specific peptidase 27, X-linked
USP6NL USP6 N-terminal like
WDR76 WD repeat domain 76
WWC2 WW and C2 domain containing 2
ZMAT5 zinc finger, matrin-type 5
ZNF230 zinc finger protein 230
ZNHIT2 zinc finger, HIT-type containing 2
ZSCAN9 zinc finger and SCAN domain containing 9