mesoridazine-7017 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the mesoridazine-7017 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACADSB acyl-CoA dehydrogenase, short/branched chain
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ART1 ADP-ribosyltransferase 1
ASMTL acetylserotonin O-methyltransferase-like
BAIAP3 BAI1-associated protein 3
BGN biglycan
BMP5 bone morphogenetic protein 5
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C10ORF95 chromosome 10 open reading frame 95
C7ORF43 chromosome 7 open reading frame 43
CAMTA1 calmodulin binding transcription activator 1
CD83 CD83 molecule
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM106A family with sequence similarity 106, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FFAR2 free fatty acid receptor 2
FHL1 four and a half LIM domains 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GSTCD glutathione S-transferase, C-terminal domain containing
HEXA hexosaminidase A (alpha polypeptide)
HFE hemochromatosis
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
IGFBP5 insulin-like growth factor binding protein 5
IGHMBP2 immunoglobulin mu binding protein 2
IQCK IQ motif containing K
IRF5 interferon regulatory factor 5
KIF3C kinesin family member 3C
KRT6B keratin 6B, type II
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
MAGED2 melanoma antigen family D2
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MSMB microseminoprotein, beta-
MSR1 macrophage scavenger receptor 1
MYOZ1 myozenin 1
NAG18 NAG18 mRNA
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NF2 neurofibromin 2 (merlin)
NRSN2 neurensin 2
OGFR opioid growth factor receptor
PACS1 phosphofurin acidic cluster sorting protein 1
PADI1 peptidyl arginine deiminase, type I
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAX5 paired box 5
PCDHGA10 protocadherin gamma subfamily A, 10
PDE3B phosphodiesterase 3B, cGMP-inhibited
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKNOX1 PBX/knotted 1 homeobox 1
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTTG2 pituitary tumor-transforming 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF39 ring finger protein 39
RRBP1 ribosome binding protein 1
RSU1 Ras suppressor protein 1
S100A8 S100 calcium binding protein A8
SASH1 SAM and SH3 domain containing 1
SCAPER S-phase cyclin A-associated protein in the ER
SCARB2 scavenger receptor class B, member 2
SCLY selenocysteine lyase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SETD1A SET domain containing 1A
SETD4 SET domain containing 4
SGSH N-sulfoglucosamine sulfohydrolase
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
SLC25A30 solute carrier family 25, member 30
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOWAHC sosondowah ankyrin repeat domain family member C
SPAST spastin
SPATA5L1 spermatogenesis associated 5-like 1
STAT5B signal transducer and activator of transcription 5B
STC1 stanniocalcin 1
SYT12 synaptotagmin XII
TARP TCR gamma alternate reading frame protein
TBC1D2 TBC1 domain family, member 2
TECTA tectorin alpha
TH tyrosine hydroxylase
TLN1 talin 1
TMEM183A transmembrane protein 183A
TMEM259 transmembrane protein 259
TTC9 tetratricopeptide repeat domain 9
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZBTB14 zinc finger and BTB domain containing 14
ZMYND8 zinc finger, MYND-type containing 8
ZNF134 zinc finger protein 134

decreased expression

Symbol Name
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANXA1 annexin A1
ATAD3A ATPase family, AAA domain containing 3A
ATAD5 ATPase family, AAA domain containing 5
ATF7IP2 activating transcription factor 7 interacting protein 2
BCORL1 BCL6 corepressor-like 1
C5ORF45 chromosome 5 open reading frame 45
CA11 carbonic anhydrase XI
CASZ1 castor zinc finger 1
CCDC170 coiled-coil domain containing 170
CCDC88C coiled-coil domain containing 88C
CCSER2 coiled-coil serine-rich protein 2
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CHKB choline kinase beta
CIDEC cell death-inducing DFFA-like effector c
COBL cordon-bleu WH2 repeat protein
CXORF56 chromosome X open reading frame 56
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DSCAM Down syndrome cell adhesion molecule
EAF2 ELL associated factor 2
EFNA3 ephrin-A3
EIF5A2 eukaryotic translation initiation factor 5A2
ELOVL4 ELOVL fatty acid elongase 4
EPHA2 EPH receptor A2
ETAA1 Ewing tumor-associated antigen 1
FBXL15 F-box and leucine-rich repeat protein 15
FCHSD2 FCH and double SH3 domains 2
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
H2AFY2 H2A histone family, member Y2
IFT140 intraflagellar transport 140
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IQSEC2 IQ motif and Sec7 domain 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
JADE1 jade family PHD finger 1
JRKL JRK-like
KCNK15 potassium channel, two pore domain subfamily K, member 15
LNPEP leucyl/cystinyl aminopeptidase
LRRC20 leucine rich repeat containing 20
LYPD1 LY6/PLAUR domain containing 1
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MBOAT2 membrane bound O-acyltransferase domain containing 2
MFSD10 major facilitator superfamily domain containing 10
MITF microphthalmia-associated transcription factor
MTHFSD methenyltetrahydrofolate synthetase domain containing
MXD3 MAX dimerization protein 3
MYO1E myosin IE
NARFL nuclear prelamin A recognition factor-like
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
ORAI3 ORAI calcium release-activated calcium modulator 3
ORC1 origin recognition complex, subunit 1
PARP6 poly (ADP-ribose) polymerase family, member 6
PC pyruvate carboxylase
PCDHA6 protocadherin alpha 6
PDLIM2 PDZ and LIM domain 2 (mystique)
PEX26 peroxisomal biogenesis factor 26
PGP phosphoglycolate phosphatase
PLD3 phospholipase D family, member 3
PPT2 palmitoyl-protein thioesterase 2
PTBP2 polypyrimidine tract binding protein 2
PTCD2 pentatricopeptide repeat domain 2
RANBP17 RAN binding protein 17
RECQL4 RecQ protein-like 4
REEP4 receptor accessory protein 4
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPUSD2 RNA pseudouridylate synthase domain containing 2
S100A4 S100 calcium binding protein A4
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOX3 SRY (sex determining region Y)-box 3
SPINK4 serine peptidase inhibitor, Kazal type 4
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STBD1 starch binding domain 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
THAP7 THAP domain containing 7
THBS3 thrombospondin 3
TMEM2 transmembrane protein 2
TRAPPC13 trafficking protein particle complex 13
TRIM25 tripartite motif containing 25
TRIP10 thyroid hormone receptor interactor 10
TSPAN1 tetraspanin 1
USP36 ubiquitin specific peptidase 36
VEGFC vascular endothelial growth factor C
VGF VGF nerve growth factor inducible
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR19 WD repeat domain 19
WDR4 WD repeat domain 4
WWC2 WW and C2 domain containing 2
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
YEATS4 YEATS domain containing 4
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF35 zinc finger protein 35
ZNF767P zinc finger family member 767, pseudogene
ZNF816 zinc finger protein 816