mesalazine-6162 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the mesalazine-6162 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ADTRP androgen-dependent TFPI-regulating protein
ALK anaplastic lymphoma receptor tyrosine kinase
APOL1 apolipoprotein L, 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BPIFA1 BPI fold containing family A, member 1
BRS3 bombesin-like receptor 3
C1ORF61 chromosome 1 open reading frame 61
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAMKV CaM kinase-like vesicle-associated
CD1E CD1e molecule
CD6 CD6 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLEC3B C-type lectin domain family 3, member B
CLEC4M C-type lectin domain family 4, member M
CLSTN2 calsyntenin 2
CLTA clathrin, light chain A
CNOT4 CCR4-NOT transcription complex, subunit 4
COL14A1 collagen, type XIV, alpha 1
COL5A2 collagen, type V, alpha 2
CPT1A carnitine palmitoyltransferase 1A (liver)
CSHL1 chorionic somatomammotropin hormone-like 1
DICER1 dicer 1, ribonuclease type III
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
EHD3 EH-domain containing 3
ELL2 elongation factor, RNA polymerase II, 2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPX eosinophil peroxidase
ERBB3 erb-b2 receptor tyrosine kinase 3
ETNK2 ethanolamine kinase 2
FAIM2 Fas apoptotic inhibitory molecule 2
FAM49B family with sequence similarity 49, member B
FBXO31 F-box protein 31
FGF17 fibroblast growth factor 17
FRMD4A FERM domain containing 4A
GAN gigaxonin
GATA2 GATA binding protein 2
GDF2 growth differentiation factor 2
GLYAT glycine-N-acyltransferase
GPC1 glypican 1
GPR137 G protein-coupled receptor 137
GRIK1 glutamate receptor, ionotropic, kainate 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAMP hepcidin antimicrobial peptide
HFE hemochromatosis
HLA-DOA major histocompatibility complex, class II, DO alpha
HOXB6 homeobox B6
HPGDS hematopoietic prostaglandin D synthase
HYAL1 hyaluronoglucosaminidase 1
IDS iduronate 2-sulfatase
IGHA1 immunoglobulin heavy constant alpha 1
IL12A interleukin 12A
ING4 inhibitor of growth family, member 4
KIF2A kinesin heavy chain member 2A
KIF5C kinesin family member 5C
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KRT1 keratin 1, type II
LOC440895 two pore channel 3 pseudogene
LYZL6 lysozyme-like 6
MAP2K7 mitogen-activated protein kinase kinase 7
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NF2 neurofibromin 2 (merlin)
NINL ninein-like
NIPAL2 NIPA-like domain containing 2
NPFF neuropeptide FF-amide peptide precursor
NRCAM neuronal cell adhesion molecule
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PACS1 phosphofurin acidic cluster sorting protein 1
PARM1 prostate androgen-regulated mucin-like protein 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PGLYRP4 peptidoglycan recognition protein 4
PKP3 plakophilin 3
PLXNB2 plexin B2
POFUT2 protein O-fucosyltransferase 2
RAB6A RAB6A, member RAS oncogene family
RET ret proto-oncogene
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC25A30 solute carrier family 25, member 30
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNJ2 synaptojanin 2
TCP10 t-complex 10
TM4SF5 transmembrane 4 L six family member 5
TMCC1 transmembrane and coiled-coil domain family 1
TMEM180 transmembrane protein 180
TNXB tenascin XB
TTC12 tetratricopeptide repeat domain 12
WNT16 wingless-type MMTV integration site family, member 16
WWTR1 WW domain containing transcription regulator 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AMBRA1 autophagy/beclin-1 regulator 1
ATP10D ATPase, class V, type 10D
BBS7 Bardet-Biedl syndrome 7
BIK BCL2-interacting killer (apoptosis-inducing)
BMI1 BMI1 proto-oncogene, polycomb ring finger
CAPN7 calpain 7
CCDC91 coiled-coil domain containing 91
CD70 CD70 molecule
CDIP1 cell death-inducing p53 target 1
CENPT centromere protein T
CNR2 cannabinoid receptor 2 (macrophage)
CRNKL1 crooked neck pre-mRNA splicing factor 1
DEPTOR DEP domain containing MTOR-interacting protein
DGKE diacylglycerol kinase, epsilon 64kDa
DNMBP dynamin binding protein
DOCK4 dedicator of cytokinesis 4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC8 excision repair cross-complementation group 8
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1LB ERO1-like beta (S. cerevisiae)
FADD Fas (TNFRSF6)-associated via death domain
FAM188A family with sequence similarity 188, member A
FHIT fragile histidine triad
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMEB1 glucocorticoid modulatory element binding protein 1
GUSBP3 glucuronidase, beta pseudogene 3
HAGH hydroxyacylglutathione hydrolase
HIST1H2AJ histone cluster 1, H2aj
HTT huntingtin
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IQGAP2 IQ motif containing GTPase activating protein 2
KIAA0754 KIAA0754
KPNA4 karyopherin alpha 4 (importin alpha 3)
L2HGDH L-2-hydroxyglutarate dehydrogenase
LPAR6 lysophosphatidic acid receptor 6
LZTR1 leucine-zipper-like transcription regulator 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK3 mitogen-activated protein kinase 3
MED15 mediator complex subunit 15
METRN meteorin, glial cell differentiation regulator
MOCOS molybdenum cofactor sulfurase
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit
NCALD neurocalcin delta
NLRX1 NLR family member X1
NPIPB3 nuclear pore complex interacting protein family, member B3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PARG poly (ADP-ribose) glycohydrolase
PCTP phosphatidylcholine transfer protein
PDZD7 PDZ domain containing 7
PIGG phosphatidylinositol glycan anchor biosynthesis, class G
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
QTRT1 queuine tRNA-ribosyltransferase 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHOBTB2 Rho-related BTB domain containing 2
RPL13P5 ribosomal protein L13 pseudogene 5
RPP25 ribonuclease P/MRP 25kDa subunit
RUSC2 RUN and SH3 domain containing 2
SAMD9 sterile alpha motif domain containing 9
SATB1 SATB homeobox 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SNORA21 small nucleolar RNA, H/ACA box 21
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK16 serine/threonine kinase 16
TBCCD1 TBCC domain containing 1
TEC tec protein tyrosine kinase
TICAM1 toll-like receptor adaptor molecule 1
TMEM156 transmembrane protein 156
TMEM159 transmembrane protein 159
TMEM209 transmembrane protein 209
TMEM242 transmembrane protein 242
TMEM260 transmembrane protein 260
TOLLIP toll interacting protein
UPB1 ureidopropionase, beta
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
YY2 YY2 transcription factor
ZBTB44 zinc finger and BTB domain containing 44
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF248 zinc finger protein 248
ZNF273 zinc finger protein 273
ZNF345 zinc finger protein 345
ZNF354A zinc finger protein 354A
ZNF529 zinc finger protein 529
ZNF573 zinc finger protein 573
ZNF804A zinc finger protein 804A