meropenem-7180 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the meropenem-7180 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACO2 aconitase 2, mitochondrial
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APC adenomatous polyposis coli
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP44 Rho GTPase activating protein 44
ATP7A ATPase, Cu++ transporting, alpha polypeptide
AVL9 AVL9 homolog (S. cerevisiase)
CCL22 chemokine (C-C motif) ligand 22
CCNO cyclin O
CDC14A cell division cycle 14A
CEMP1 cementum protein 1
CEP164 centrosomal protein 164kDa
CHKB choline kinase beta
CNPY4 canopy FGF signaling regulator 4
COL14A1 collagen, type XIV, alpha 1
COMT catechol-O-methyltransferase
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CPD carboxypeptidase D
CSE1L CSE1 chromosome segregation 1-like (yeast)
DAPK3 death-associated protein kinase 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DOK4 docking protein 4
EGFR epidermal growth factor receptor
ELSPBP1 epididymal sperm binding protein 1
EXTL3 exostosin-like glycosyltransferase 3
FBXO40 F-box protein 40
FSHB follicle stimulating hormone, beta polypeptide
FZD1 frizzled class receptor 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GMEB1 glucocorticoid modulatory element binding protein 1
HFE hemochromatosis
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMOX1 heme oxygenase 1
HP1BP3 heterochromatin protein 1, binding protein 3
IFT140 intraflagellar transport 140
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITGA10 integrin, alpha 10
ITGA6 integrin, alpha 6
LIG4 ligase IV, DNA, ATP-dependent
LYPD1 LY6/PLAUR domain containing 1
LZTR1 leucine-zipper-like transcription regulator 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MECOM MDS1 and EVI1 complex locus
MPPED2 metallophosphoesterase domain containing 2
MTSS1L metastasis suppressor 1-like
MXD4 MAX dimerization protein 4
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NF1 neurofibromin 1
NIPAL2 NIPA-like domain containing 2
NKTR natural killer cell triggering receptor
NOP14-AS1 NOP14 antisense RNA 1
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
OSMR oncostatin M receptor
PARD6B par-6 family cell polarity regulator beta
PCM1 pericentriolar material 1
PLK4 polo-like kinase 4
PLXNC1 plexin C1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PSPH phosphoserine phosphatase
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RBM5 RNA binding motif protein 5
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RFXAP regulatory factor X-associated protein
RNF6 ring finger protein (C3H2C3 type) 6
RPL23AP32 ribosomal protein L23a pseudogene 32
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
SFXN3 sideroflexin 3
SH3BP2 SH3-domain binding protein 2
SKIL SKI-like proto-oncogene
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC39A9 solute carrier family 39, member 9
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SRI sorcin
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAPBP TAP binding protein (tapasin)
TAZ tafazzin
TJP3 tight junction protein 3
TMEM63A transmembrane protein 63A
TMPRSS2 transmembrane protease, serine 2
TRAPPC13 trafficking protein particle complex 13
TXNIP thioredoxin interacting protein
TXNL4A thioredoxin-like 4A
VEZT vezatin, adherens junctions transmembrane protein
WNT16 wingless-type MMTV integration site family, member 16
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZNF573 zinc finger protein 573

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
AHDC1 AT hook, DNA binding motif, containing 1
ALPK1 alpha-kinase 1
ANKRD36 ankyrin repeat domain 36
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARID3A AT rich interactive domain 3A (BRIGHT-like)
BBS10 Bardet-Biedl syndrome 10
BCL9 B-cell CLL/lymphoma 9
BCORL1 BCL6 corepressor-like 1
BSDC1 BSD domain containing 1
BTBD2 BTB (POZ) domain containing 2
C14ORF132 chromosome 14 open reading frame 132
C19ORF40 chromosome 19 open reading frame 40
CBX4 chromobox homolog 4
CCDC88C coiled-coil domain containing 88C
CCDC92 coiled-coil domain containing 92
CCNT1 cyclin T1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CKB creatine kinase, brain
CLASRP CLK4-associating serine/arginine rich protein
COL9A2 collagen, type IX, alpha 2
COPS7B COP9 signalosome subunit 7B
CXORF56 chromosome X open reading frame 56
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DSPP dentin sialophosphoprotein
EVPL envoplakin
FAM114A1 family with sequence similarity 114, member A1
FAM188A family with sequence similarity 188, member A
FAM53B family with sequence similarity 53, member B
FBXL6 F-box and leucine-rich repeat protein 6
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOXC1 forkhead box C1
GRAMD4 GRAM domain containing 4
GTPBP6 GTP binding protein 6 (putative)
HIST1H2AI histone cluster 1, H2ai
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IPO8 importin 8
IRF7 interferon regulatory factor 7
ITPKC inositol-trisphosphate 3-kinase C
KIAA0922 KIAA0922
LAMB2 laminin, beta 2 (laminin S)
LOXL1 lysyl oxidase-like 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP6D1 MAP6 domain containing 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MAST3 microtubule associated serine/threonine kinase 3
MBD5 methyl-CpG binding domain protein 5
MED15 mediator complex subunit 15
MFSD10 major facilitator superfamily domain containing 10
MFSD12 major facilitator superfamily domain containing 12
MXD3 MAX dimerization protein 3
NEO1 neogenin 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRGN neurogranin (protein kinase C substrate, RC3)
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PCDHB3 protocadherin beta 3
PCSK7 proprotein convertase subtilisin/kexin type 7
PLD3 phospholipase D family, member 3
PNPLA6 patatin-like phospholipase domain containing 6
PPT2 palmitoyl-protein thioesterase 2
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB33B RAB33B, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF170 ring finger protein 170
RNF25 ring finger protein 25
SAMHD1 SAM domain and HD domain 1
SECISBP2L SECIS binding protein 2-like
SH2D4A SH2 domain containing 4A
SHPK sedoheptulokinase
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SNX16 sorting nexin 16
STAG3 stromal antigen 3
TBX19 T-box 19
TMEM110 transmembrane protein 110
TMEM132A transmembrane protein 132A
TRAIP TRAF interacting protein
TSPAN14 tetraspanin 14
TUBA3C tubulin, alpha 3c
TUBGCP5 tubulin, gamma complex associated protein 5
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBIAD1 UbiA prenyltransferase domain containing 1
UBXN6 UBX domain protein 6
VWA1 von Willebrand factor A domain containing 1
YEATS2 YEATS domain containing 2
ZBTB48 zinc finger and BTB domain containing 48
ZNF254 zinc finger protein 254
ZNF552 zinc finger protein 552
ZNF813 zinc finger protein 813
ZNHIT2 zinc finger, HIT-type containing 2