meropenem-6141 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the meropenem-6141 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
AMPH amphiphysin
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
BIN1 bridging integrator 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CASC1 cancer susceptibility candidate 1
CCDC57 coiled-coil domain containing 57
CDRT1 CMT1A duplicated region transcript 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHRM3 cholinergic receptor, muscarinic 3
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLTA clathrin, light chain A
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNR1 cannabinoid receptor 1 (brain)
COL17A1 collagen, type XVII, alpha 1
CRTC1 CREB regulated transcription coactivator 1
DAGLA diacylglycerol lipase, alpha
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ELAVL4 ELAV like neuron-specific RNA binding protein 4
EPHA1 EPH receptor A1
F2R coagulation factor II (thrombin) receptor
FBXO2 F-box protein 2
FOXD2 forkhead box D2
FOXG1 forkhead box G1
FUS FUS RNA binding protein
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GHRHR growth hormone releasing hormone receptor
GLRA1 glycine receptor, alpha 1
GLRB glycine receptor, beta
GPATCH4 G patch domain containing 4
GPR132 G protein-coupled receptor 132
GTPBP1 GTP binding protein 1
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IDS iduronate 2-sulfatase
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
KAT8 K(lysine) acetyltransferase 8
KIAA1462 KIAA1462
KIF25-AS1 KIF25 antisense RNA 1
KRT8 keratin 8, type II
KYNU kynureninase
L1TD1 LINE-1 type transposase domain containing 1
LMTK2 lemur tyrosine kinase 2
LPPR1 lipid phosphate phosphatase-related protein type 1
MMP3 matrix metallopeptidase 3
MPL MPL proto-oncogene, thrombopoietin receptor
MRPL41 mitochondrial ribosomal protein L41
MTMR3 myotubularin related protein 3
MYH14 myosin, heavy chain 14, non-muscle
NEUROD1 neuronal differentiation 1
NF2 neurofibromin 2 (merlin)
NPFF neuropeptide FF-amide peptide precursor
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NXPH4 neurexophilin 4
ONECUT2 one cut homeobox 2
OSBPL7 oxysterol binding protein-like 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNXL2 pecanex-like 2 (Drosophila)
PDLIM4 PDZ and LIM domain 4
PDZRN3 PDZ domain containing ring finger 3
PPEF1 protein phosphatase, EF-hand calcium binding domain 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRSS53 protease, serine, 53
RERGL RERG/RAS-like
RHBDD3 rhomboid domain containing 3
RIF1 replication timing regulatory factor 1
SCAND2P SCAN domain containing 2 pseudogene
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SH3GL3 SH3-domain GRB2-like 3
SLAMF7 SLAM family member 7
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPRR2B small proline-rich protein 2B
SPTBN1 spectrin, beta, non-erythrocytic 1
ST7L suppression of tumorigenicity 7 like
STMN4 stathmin-like 4
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCL1A T-cell leukemia/lymphoma 1A
TEF thyrotrophic embryonic factor
TM4SF4 transmembrane 4 L six family member 4
TMC7 transmembrane channel-like 7
TNK1 tyrosine kinase, non-receptor, 1
TP53I11 tumor protein p53 inducible protein 11
TPMT thiopurine S-methyltransferase
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC38 tetratricopeptide repeat domain 38
XIST X inactive specific transcript (non-protein coding)
XYLB xylulokinase homolog (H. influenzae)
YLPM1 YLP motif containing 1
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
AMIGO2 adhesion molecule with Ig-like domain 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ARRB1 arrestin, beta 1
BAG3 BCL2-associated athanogene 3
C11ORF68 chromosome 11 open reading frame 68
C14ORF93 chromosome 14 open reading frame 93
C9ORF9 chromosome 9 open reading frame 9
CAMKMT calmodulin-lysine N-methyltransferase
CCDC9 coiled-coil domain containing 9
CD82 CD82 molecule
CDR2L cerebellar degeneration-related protein 2-like
CHMP7 charged multivesicular body protein 7
CKB creatine kinase, brain
COG4 component of oligomeric golgi complex 4
COL15A1 collagen, type XV, alpha 1
CORO7 coronin 7
CTSO cathepsin O
CUX2 cut-like homeobox 2
DCAF17 DDB1 and CUL4 associated factor 17
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM188A family with sequence similarity 188, member A
FCF1 FCF1 rRNA-processing protein
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FJX1 four jointed box 1 (Drosophila)
GK3P glycerol kinase 3 pseudogene
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GPALPP1 GPALPP motifs containing 1
GPATCH3 G patch domain containing 3
GUSBP3 glucuronidase, beta pseudogene 3
HCAR3 hydroxycarboxylic acid receptor 3
HIRA histone cell cycle regulator
HIST1H2BN histone cluster 1, H2bn
HP haptoglobin
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
KIAA0753 KIAA0753
KIF3C kinesin family member 3C
MAGEF1 melanoma antigen family F1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MDM4 MDM4, p53 regulator
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5M 5',3'-nucleotidase, mitochondrial
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCYOX1 prenylcysteine oxidase 1
PDGFD platelet derived growth factor D
PDLIM2 PDZ and LIM domain 2 (mystique)
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PMP22 peripheral myelin protein 22
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRICKLE3 prickle homolog 3 (Drosophila)
PWAR5 Prader Willi/Angelman region RNA 5
PYGB phosphorylase, glycogen; brain
RGS13 regulator of G-protein signaling 13
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHOH ras homolog family member H
RUSC2 RUN and SH3 domain containing 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SETD8 SET domain containing (lysine methyltransferase) 8
SIGLEC9 sialic acid binding Ig-like lectin 9
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPATS2 spermatogenesis associated, serine-rich 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
THAP10 THAP domain containing 10
TMEM242 transmembrane protein 242
TRIM36 tripartite motif containing 36
TSPAN32 tetraspanin 32
TSPYL2 TSPY-like 2
TTLL1 tubulin tyrosine ligase-like family member 1
UNC93B1 unc-93 homolog B1 (C. elegans)
UPK3A uroplakin 3A
UPP1 uridine phosphorylase 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR76 WD repeat domain 76
WDR91 WD repeat domain 91
WWC3 WWC family member 3
YY2 YY2 transcription factor
ZBTB10 zinc finger and BTB domain containing 10
ZBTB38 zinc finger and BTB domain containing 38
ZBTB39 zinc finger and BTB domain containing 39
ZBTB6 zinc finger and BTB domain containing 6
ZFP37 ZFP37 zinc finger protein
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF35 zinc finger protein 35
ZNF862 zinc finger protein 862