mercaptopurine-667 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the mercaptopurine-667 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ADH6 alcohol dehydrogenase 6 (class V)
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ATF6 activating transcription factor 6
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BIK BCL2-interacting killer (apoptosis-inducing)
BIN1 bridging integrator 1
BLK BLK proto-oncogene, Src family tyrosine kinase
BLMH bleomycin hydrolase
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAMTA2 calmodulin binding transcription activator 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD8A CD8a molecule
CHERP calcium homeostasis endoplasmic reticulum protein
CHRM4 cholinergic receptor, muscarinic 4
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN1 claudin 1
CNTN1 contactin 1
CRYM crystallin, mu
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43
DEDD death effector domain containing
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DISC1 disrupted in schizophrenia 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
ECE2 endothelin converting enzyme 2
FN1 fibronectin 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GAB1 GRB2-associated binding protein 1
GBAP1 glucosidase, beta, acid pseudogene 1
GLRX3 glutaredoxin 3
GOSR1 golgi SNAP receptor complex member 1
GPR107 G protein-coupled receptor 107
H2AFY2 H2A histone family, member Y2
HOXD9 homeobox D9
HRH1 histamine receptor H1
INO80B INO80 complex subunit B
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KATNBL1 katanin p80 subunit B-like 1
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KHK ketohexokinase (fructokinase)
KIAA1045 KIAA1045
KLHL1 kelch-like family member 1
KYNU kynureninase
LMO3 LIM domain only 3 (rhombotin-like 2)
LPP LIM domain containing preferred translocation partner in lipoma
LRRN2 leucine rich repeat neuronal 2
MBNL2 muscleblind-like splicing regulator 2
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MED1 mediator complex subunit 1
MT1G metallothionein 1G
MYL10 myosin, light chain 10, regulatory
MYL12B myosin, light chain 12B, regulatory
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYLIP myosin regulatory light chain interacting protein
NCS1 neuronal calcium sensor 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
NUP214 nucleoporin 214kDa
PASK PAS domain containing serine/threonine kinase
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PKP1 plakophilin 1
PLIN2 perilipin 2
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTH1R parathyroid hormone 1 receptor
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB29 RAB29, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
REC8 REC8 meiotic recombination protein
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RGS3 regulator of G-protein signaling 3
RNF141 ring finger protein 141
RUNDC3A RUN domain containing 3A
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPRR1A small proline-rich protein 1A
SYNGR1 synaptogyrin 1
TAGLN3 transgelin 3
TBC1D2B TBC1 domain family, member 2B
TLE3 transducin-like enhancer of split 3
TMEM97 transmembrane protein 97
TP53I11 tumor protein p53 inducible protein 11
TP63 tumor protein p63
TRIB2 tribbles pseudokinase 2
TSKU tsukushi, small leucine rich proteoglycan
TTLL4 tubulin tyrosine ligase-like family member 4
TWIST1 twist family bHLH transcription factor 1
WDR61 WD repeat domain 61
WNK1 WNK lysine deficient protein kinase 1
WWC2 WW and C2 domain containing 2
ZNF778 zinc finger protein 778
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ADRB2 adrenoceptor beta 2, surface
ANAPC2 anaphase promoting complex subunit 2
ARHGAP5 Rho GTPase activating protein 5
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARMC7 armadillo repeat containing 7
ASCC1 activating signal cointegrator 1 complex subunit 1
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATXN2 ataxin 2
AXIN1 axin 1
BCAR3 breast cancer anti-estrogen resistance 3
BHLHE41 basic helix-loop-helix family, member e41
C1ORF56 chromosome 1 open reading frame 56
CA5BP1 carbonic anhydrase VB pseudogene 1
CCNA1 cyclin A1
CCS copper chaperone for superoxide dismutase
CDH18 cadherin 18, type 2
CDK3 cyclin-dependent kinase 3
CDR2L cerebellar degeneration-related protein 2-like
CHD1 chromodomain helicase DNA binding protein 1
CPOX coproporphyrinogen oxidase
CRYBG3 beta-gamma crystallin domain containing 3
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTNNBIP1 catenin, beta interacting protein 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
ELP6 elongator acetyltransferase complex subunit 6
ERF Ets2 repressor factor
EXOSC9 exosome component 9
FUZ fuzzy planar cell polarity protein
GALK1 galactokinase 1
GDF9 growth differentiation factor 9
GPR21 G protein-coupled receptor 21
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HIST1H4J histone cluster 1, H4j
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLX H2.0-like homeobox
HMGA2 high mobility group AT-hook 2
HMHA1 histocompatibility (minor) HA-1
IL22 interleukin 22
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IRS1 insulin receptor substrate 1
ITPKB inositol-trisphosphate 3-kinase B
KIF18A kinesin family member 18A
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLF3 Kruppel-like factor 3 (basic)
KRI1 KRI1 homolog (S. cerevisiae)
LINC00339 long intergenic non-protein coding RNA 339
LIPG lipase, endothelial
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPK3 mitogen-activated protein kinase 3
MED23 mediator complex subunit 23
MOB3B MOB kinase activator 3B
NME3 NME/NM23 nucleoside diphosphate kinase 3
NRIP1 nuclear receptor interacting protein 1
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUPL2 nucleoporin like 2
NVL nuclear VCP-like
OSGIN1 oxidative stress induced growth inhibitor 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PELP1 proline, glutamate and leucine rich protein 1
PLAU plasminogen activator, urokinase
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLM polymerase (DNA directed), mu
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PTDSS2 phosphatidylserine synthase 2
PTX3 pentraxin 3, long
RAD54L RAD54-like (S. cerevisiae)
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RSPH6A radial spoke head 6 homolog A (Chlamydomonas)
SIX1 SIX homeobox 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC35F6 solute carrier family 35, member F6
SMO smoothened, frizzled class receptor
SNAI2 snail family zinc finger 2
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
STAU2 staufen double-stranded RNA binding protein 2
TBX3 T-box 3
THBS4 thrombospondin 4
TJP2 tight junction protein 2
TMEM8A transmembrane protein 8A
TMOD3 tropomodulin 3 (ubiquitous)
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRAPPC12 trafficking protein particle complex 12
TRPS1 trichorhinophalangeal syndrome I
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN5 tetraspanin 5
USB1 U6 snRNA biogenesis 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
WDR41 WD repeat domain 41
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF432 zinc finger protein 432
ZNF671 zinc finger protein 671
ZNF696 zinc finger protein 696
ZNF787 zinc finger protein 787