merbromin-7398 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the merbromin-7398 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
AMT aminomethyltransferase
AP1M2 adaptor-related protein complex 1, mu 2 subunit
APOL6 apolipoprotein L, 6
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ATP10A ATPase, class V, type 10A
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
CCNJ cyclin J
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CLDN11 claudin 11
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CNGB3 cyclic nucleotide gated channel beta 3
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COL9A2 collagen, type IX, alpha 2
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHODH dihydroorotate dehydrogenase (quinone)
E2F1 E2F transcription factor 1
EDA ectodysplasin A
EDN1 endothelin 1
EMP1 epithelial membrane protein 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ERCC5 excision repair cross-complementation group 5
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FAM186A family with sequence similarity 186, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FH fumarate hydratase
GIPC2 GIPC PDZ domain containing family, member 2
GLP1R glucagon-like peptide 1 receptor
HBB hemoglobin, beta
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HSDL2 hydroxysteroid dehydrogenase like 2
IDS iduronate 2-sulfatase
IL11 interleukin 11
IRS2 insulin receptor substrate 2
KAZN kazrin, periplakin interacting protein
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KDM4B lysine (K)-specific demethylase 4B
KIAA1644 KIAA1644
KLF13 Kruppel-like factor 13
KLHL22 kelch-like family member 22
KRT6B keratin 6B, type II
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAP2K5 mitogen-activated protein kinase kinase 5
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MTSS1L metastasis suppressor 1-like
MTUS1 microtubule associated tumor suppressor 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPH2 non-SMC condensin II complex, subunit H2
NPAS2 neuronal PAS domain protein 2
NPEPL1 aminopeptidase-like 1
OASL 2'-5'-oligoadenylate synthetase-like
OSBPL2 oxysterol binding protein-like 2
PAX2 paired box 2
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE8B phosphodiesterase 8B
PDZK1 PDZ domain containing 1
PER1 period circadian clock 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIDD1 p53-induced death domain protein 1
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PMCH pro-melanin-concentrating hormone
POMT2 protein-O-mannosyltransferase 2
PRSS53 protease, serine, 53
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RAB26 RAB26, member RAS oncogene family
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RER1 retention in endoplasmic reticulum sorting receptor 1
RUNX1 runt-related transcription factor 1
S100A11 S100 calcium binding protein A11
S1PR1 sphingosine-1-phosphate receptor 1
SAA4 serum amyloid A4, constitutive
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SIGLEC8 sialic acid binding Ig-like lectin 8
SIX1 SIX homeobox 1
SLC35F6 solute carrier family 35, member F6
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SMG7 SMG7 nonsense mediated mRNA decay factor
SOX21 SRY (sex determining region Y)-box 21
SOX4 SRY (sex determining region Y)-box 4
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STX6 syntaxin 6
TBCD tubulin folding cofactor D
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TSNAXIP1 translin-associated factor X interacting protein 1
TSPAN9 tetraspanin 9
TTC12 tetratricopeptide repeat domain 12
UBE3B ubiquitin protein ligase E3B
UBOX5 U-box domain containing 5
UNC93B1 unc-93 homolog B1 (C. elegans)
ZER1 zyg-11 related, cell cycle regulator
ZFP36L1 ZFP36 ring finger protein-like 1
ZKSCAN5 zinc finger with KRAB and SCAN domains 5
ZNF141 zinc finger protein 141

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADGRG2 adhesion G protein-coupled receptor G2
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BCAS3 breast carcinoma amplified sequence 3
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
CASZ1 castor zinc finger 1
CBX4 chromobox homolog 4
CBX8 chromobox homolog 8
CCNO cyclin O
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CENPJ centromere protein J
CEP83 centrosomal protein 83kDa
CFAP69 cilia and flagella associated protein 69
CHM choroideremia (Rab escort protein 1)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CPEB1 cytoplasmic polyadenylation element binding protein 1
CUL9 cullin 9
DBR1 debranching RNA lariats 1
DCAF17 DDB1 and CUL4 associated factor 17
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNM1 dynamin 1
ELP3 elongator acetyltransferase complex subunit 3
ELP6 elongator acetyltransferase complex subunit 6
EPHA4 EPH receptor A4
EPHB6 EPH receptor B6
ERN2 endoplasmic reticulum to nucleus signaling 2
EYA3 EYA transcriptional coactivator and phosphatase 3
GTF2I general transcription factor IIi
HIST1H2AM histone cluster 1, H2am
HOOK1 hook microtubule-tethering protein 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGSF3 immunoglobulin superfamily, member 3
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IREB2 iron-responsive element binding protein 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITPKC inositol-trisphosphate 3-kinase C
KCTD20 potassium channel tetramerization domain containing 20
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
LINS lines homolog (Drosophila)
LMO7 LIM domain 7
LPAR6 lysophosphatidic acid receptor 6
LRRC37A3 leucine rich repeat containing 37, member A3
LTBP2 latent transforming growth factor beta binding protein 2
MAGEA6 melanoma antigen family A6
MAN2C1 mannosidase, alpha, class 2C, member 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCC mutated in colorectal cancers
MED15 mediator complex subunit 15
MFSD11 major facilitator superfamily domain containing 11
MITF microphthalmia-associated transcription factor
MOB3B MOB kinase activator 3B
NDRG4 NDRG family member 4
NOL12 nucleolar protein 12
OLFML3 olfactomedin-like 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAQR4 progestin and adipoQ receptor family member IV
PCDHGB5 protocadherin gamma subfamily B, 5
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PRR3 proline rich 3
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RASA2 RAS p21 protein activator 2
RCAN3 RCAN family member 3
RIN1 Ras and Rab interactor 1
SCG5 secretogranin V
SECISBP2 SECIS binding protein 2
SERTAD3 SERTA domain containing 3
SETD6 SET domain containing 6
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SNTA1 syntrophin, alpha 1
SPEG SPEG complex locus
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYTL2 synaptotagmin-like 2
TMEM53 transmembrane protein 53
TMEM8B transmembrane protein 8B
TRIM25 tripartite motif containing 25
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TSC22D4 TSC22 domain family, member 4
TSPAN15 tetraspanin 15
TXLNG taxilin gamma
VGF VGF nerve growth factor inducible
YOD1 YOD1 deubiquitinase
ZBTB48 zinc finger and BTB domain containing 48
ZMAT5 zinc finger, matrin-type 5
ZNF10 zinc finger protein 10
ZNF254 zinc finger protein 254
ZNF408 zinc finger protein 408
ZNF669 zinc finger protein 669