meprylcaine-6123 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the meprylcaine-6123 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI2 abl-interactor 2
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADARB1 adenosine deaminase, RNA-specific, B1
ANXA9 annexin A9
ASB9 ankyrin repeat and SOCS box containing 9
ATN1 atrophin 1
ATP9B ATPase, class II, type 9B
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
BPI bactericidal/permeability-increasing protein
C11ORF16 chromosome 11 open reading frame 16
CALCA calcitonin-related polypeptide alpha
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CES3 carboxylesterase 3
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLDN11 claudin 11
CLDN5 claudin 5
CLTA clathrin, light chain A
CNGB1 cyclic nucleotide gated channel beta 1
COL18A1 collagen, type XVIII, alpha 1
CUZD1 CUB and zona pellucida-like domains 1
CXXC4 CXXC finger protein 4
DOCK5 dedicator of cytokinesis 5
DSCAM Down syndrome cell adhesion molecule
DUSP7 dual specificity phosphatase 7
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EMP1 epithelial membrane protein 1
EPHB2 EPH receptor B2
FBXO31 F-box protein 31
FGFR2 fibroblast growth factor receptor 2
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FPR2 formyl peptide receptor 2
FUZ fuzzy planar cell polarity protein
GIPR gastric inhibitory polypeptide receptor
GPATCH4 G patch domain containing 4
GPC1 glypican 1
GPM6A glycoprotein M6A
GPR31 G protein-coupled receptor 31
GUK1 guanylate kinase 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HLA-DOA major histocompatibility complex, class II, DO alpha
HUS1 HUS1 checkpoint homolog (S. pombe)
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IQCK IQ motif containing K
IQSEC1 IQ motif and Sec7 domain 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KDM4B lysine (K)-specific demethylase 4B
KYNU kynureninase
LAD1 ladinin 1
LEPR leptin receptor
LGSN lengsin, lens protein with glutamine synthetase domain
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3AP minichromosome maintenance complex component 3 associated protein
MFSD6 major facilitator superfamily domain containing 6
MSX1 msh homeobox 1
MYOZ2 myozenin 2
NIPAL2 NIPA-like domain containing 2
NLK nemo-like kinase
NPR1 natriuretic peptide receptor 1
NRP2 neuropilin 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAIP2B poly(A) binding protein interacting protein 2B
PASK PAS domain containing serine/threonine kinase
PDZK1 PDZ domain containing 1
PLCE1 phospholipase C, epsilon 1
PLEKHS1 pleckstrin homology domain containing, family S member 1
PLK3 polo-like kinase 3
PML promyelocytic leukemia
POU3F2 POU class 3 homeobox 2
PPAP2B phosphatidic acid phosphatase type 2B
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PSEN2 presenilin 2
PTGDR2 prostaglandin D2 receptor 2
RAB40C RAB40C, member RAS oncogene family
REC8 REC8 meiotic recombination protein
RGS4 regulator of G-protein signaling 4
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RTCA RNA 3'-terminal phosphate cyclase
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLAMF7 SLAM family member 7
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SP1 Sp1 transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAP1 signal transducing adaptor family member 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBC1D19 TBC1 domain family, member 19
TP53I11 tumor protein p53 inducible protein 11
TUBG2 tubulin, gamma 2
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VGF VGF nerve growth factor inducible
WSB1 WD repeat and SOCS box containing 1
ZIM2 zinc finger, imprinted 2
ZNF668 zinc finger protein 668

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BIRC3 baculoviral IAP repeat containing 3
BTF3P11 basic transcription factor 3 pseudogene 11
C16ORF59 chromosome 16 open reading frame 59
C17ORF80 chromosome 17 open reading frame 80
C7ORF69 chromosome 7 open reading frame 69
C9ORF9 chromosome 9 open reading frame 9
CA5BP1 carbonic anhydrase VB pseudogene 1
CBR3 carbonyl reductase 3
CCDC85C coiled-coil domain containing 85C
CDHR2 cadherin-related family member 2
CDON cell adhesion associated, oncogene regulated
CDR2L cerebellar degeneration-related protein 2-like
CHM choroideremia (Rab escort protein 1)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNTNAP1 contactin associated protein 1
CPNE7 copine VII
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRMP1 collapsin response mediator protein 1
CTNNBIP1 catenin, beta interacting protein 1
CTSO cathepsin O
CYB5R2 cytochrome b5 reductase 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DCAF13 DDB1 and CUL4 associated factor 13
DCAF17 DDB1 and CUL4 associated factor 17
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNM3 dynamin 3
FGFBP1 fibroblast growth factor binding protein 1
GAA glucosidase, alpha; acid
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GADD45G growth arrest and DNA-damage-inducible, gamma
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GP6 glycoprotein VI (platelet)
GPR21 G protein-coupled receptor 21
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GPX2 glutathione peroxidase 2
GSPT2 G1 to S phase transition 2
GTF2I general transcription factor IIi
HHLA3 HERV-H LTR-associating 3
HIST1H2AJ histone cluster 1, H2aj
HSPB8 heat shock 22kDa protein 8
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KLF3 Kruppel-like factor 3 (basic)
LOC730101 uncharacterized LOC730101
LYRM9 LYR motif containing 9
MEGF8 multiple EGF-like-domains 8
MMRN2 multimerin 2
MNX1 motor neuron and pancreas homeobox 1
MST1 macrophage stimulating 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFE2L3 nuclear factor, erythroid 2-like 3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NSUN6 NOP2/Sun domain family, member 6
OMG oligodendrocyte myelin glycoprotein
OR1G1 olfactory receptor, family 1, subfamily G, member 1
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PAQR4 progestin and adipoQ receptor family member IV
PAQR6 progestin and adipoQ receptor family member VI
PHF14 PHD finger protein 14
PIPOX pipecolic acid oxidase
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G3 phospholipase A2, group III
PLCD1 phospholipase C, delta 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R26 protein phosphatase 1, regulatory subunit 26
PRR14L proline rich 14-like
RUSC2 RUN and SH3 domain containing 2
SCAMP5 secretory carrier membrane protein 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCE sarcoglycan, epsilon
SH2D4A SH2 domain containing 4A
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIK1 salt-inducible kinase 1
SMR3A submaxillary gland androgen regulated protein 3A
SPATA1 spermatogenesis associated 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAOK1 TAO kinase 1
TGFBR3 transforming growth factor, beta receptor III
TIMP2 TIMP metallopeptidase inhibitor 2
TM4SF20 transmembrane 4 L six family member 20
TMEM134 transmembrane protein 134
TMEM53 transmembrane protein 53
TOM1 target of myb1 (chicken)
TSPAN2 tetraspanin 2
TTLL1 tubulin tyrosine ligase-like family member 1
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
UPB1 ureidopropionase, beta
USP19 ubiquitin specific peptidase 19
ZC3H12A zinc finger CCCH-type containing 12A
ZFP37 ZFP37 zinc finger protein
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF234 zinc finger protein 234