mephentermine-7384 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the mephentermine-7384 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ACOT11 acyl-CoA thioesterase 11
ACVR1B activin A receptor, type IB
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ARHGAP35 Rho GTPase activating protein 35
ATP11A ATPase, class VI, type 11A
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BAIAP3 BAI1-associated protein 3
BGLAP bone gamma-carboxyglutamate (gla) protein
BLZF1 basic leucine zipper nuclear factor 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCPG1 cell cycle progression 1
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CSRNP3 cysteine-serine-rich nuclear protein 3
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DENND2A DENN/MADD domain containing 2A
DOHH deoxyhypusine hydroxylase/monooxygenase
DRD2 dopamine receptor D2
EFNA3 ephrin-A3
ELOVL5 ELOVL fatty acid elongase 5
EPHB2 EPH receptor B2
ETV1 ets variant 1
FAM120C family with sequence similarity 120C
FAS Fas cell surface death receptor
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FKBP10 FK506 binding protein 10, 65 kDa
FKBP8 FK506 binding protein 8, 38kDa
FZD1 frizzled class receptor 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GRM2 glutamate receptor, metabotropic 2
GUK1 guanylate kinase 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HN1L hematological and neurological expressed 1-like
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFITM1 interferon induced transmembrane protein 1
IFT74 intraflagellar transport 74
IL11 interleukin 11
IRAK4 interleukin-1 receptor-associated kinase 4
JUNB jun B proto-oncogene
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIRREL kin of IRRE like (Drosophila)
LCAT lecithin-cholesterol acyltransferase
LIMK2 LIM domain kinase 2
LPIN1 lipin 1
LRP5L low density lipoprotein receptor-related protein 5-like
MAPK11 mitogen-activated protein kinase 11
MIIP migration and invasion inhibitory protein
MLX MLX, MAX dimerization protein
MRPL57 mitochondrial ribosomal protein L57
MTRF1L mitochondrial translational release factor 1-like
NPEPL1 aminopeptidase-like 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PAPPA2 pappalysin 2
PBX2 pre-B-cell leukemia homeobox 2
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDS5A PDS5 cohesin associated factor A
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLK4 polo-like kinase 4
POLH polymerase (DNA directed), eta
POMT2 protein-O-mannosyltransferase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTCH1 patched 1
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRU protein tyrosine phosphatase, receptor type, U
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB31 RAB31, member RAS oncogene family
RAB36 RAB36, member RAS oncogene family
RABGAP1 RAB GTPase activating protein 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS4 regulator of G-protein signaling 4
RUSC2 RUN and SH3 domain containing 2
SEC14L2 SEC14-like 2 (S. cerevisiae)
SENP6 SUMO1/sentrin specific peptidase 6
SETD2 SET domain containing 2
SETD8 SET domain containing (lysine methyltransferase) 8
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH2D3A SH2 domain containing 3A
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SMC1A structural maintenance of chromosomes 1A
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNX2 sorting nexin 2
SSBP3 single stranded DNA binding protein 3
STARD3 StAR-related lipid transfer (START) domain containing 3
TAGLN3 transgelin 3
TBC1D2B TBC1 domain family, member 2B
TMEM231 transmembrane protein 231
TRAPPC13 trafficking protein particle complex 13
UNC93B1 unc-93 homolog B1 (C. elegans)
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF428 zinc finger protein 428
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ADGRG2 adhesion G protein-coupled receptor G2
AFAP1 actin filament associated protein 1
ALPK1 alpha-kinase 1
ALS2CL ALS2 C-terminal like
ANXA2P1 annexin A2 pseudogene 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATP10D ATPase, class V, type 10D
ATP13A2 ATPase type 13A2
ATP7B ATPase, Cu++ transporting, beta polypeptide
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL9 B-cell CLL/lymphoma 9
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C7ORF43 chromosome 7 open reading frame 43
CA5BP1 carbonic anhydrase VB pseudogene 1
CAPN15 calpain 15
CASZ1 castor zinc finger 1
CCDC106 coiled-coil domain containing 106
CCNO cyclin O
CDH7 cadherin 7, type 2
CDON cell adhesion associated, oncogene regulated
CLEC10A C-type lectin domain family 10, member A
CLEC2B C-type lectin domain family 2, member B
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CTSD cathepsin D
CUL9 cullin 9
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ELP6 elongator acetyltransferase complex subunit 6
F3 coagulation factor III (thromboplastin, tissue factor)
FBXL15 F-box and leucine-rich repeat protein 15
FPGS folylpolyglutamate synthase
GAA glucosidase, alpha; acid
GALK1 galactokinase 1
GATA6 GATA binding protein 6
GMIP GEM interacting protein
GRHL2 grainyhead-like 2 (Drosophila)
GTPBP2 GTP binding protein 2
HIST1H3A histone cluster 1, H3a
HIST1H3G histone cluster 1, H3g
HOXC10 homeobox C10
IFT81 intraflagellar transport 81
IMPACT impact RWD domain protein
IREB2 iron-responsive element binding protein 2
IRF9 interferon regulatory factor 9
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
MANEA mannosidase, endo-alpha
MCC mutated in colorectal cancers
MCTP1 multiple C2 domains, transmembrane 1
MED15 mediator complex subunit 15
NDE1 nudE neurodevelopment protein 1
NFS1 NFS1 cysteine desulfurase
NT5M 5',3'-nucleotidase, mitochondrial
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PARM1 prostate androgen-regulated mucin-like protein 1
PID1 phosphotyrosine interaction domain containing 1
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRKX protein kinase, X-linked
RAD54L2 RAD54-like 2 (S. cerevisiae)
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RUNX1-IT1 RUNX1 intronic transcript 1
SCARA3 scavenger receptor class A, member 3
SCEL sciellin
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH2D4A SH2 domain containing 4A
SIGLEC15 sialic acid binding Ig-like lectin 15
SIRT6 sirtuin 6
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SNTA1 syntrophin, alpha 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD5 StAR-related lipid transfer (START) domain containing 5
SYNPO synaptopodin
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TMEM183A transmembrane protein 183A
TMEM212 transmembrane protein 212
TMEM8B transmembrane protein 8B
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNNI3 troponin I type 3 (cardiac)
TNS2 tensin 2
TOR4A torsin family 4, member A
TPCN1 two pore segment channel 1
TRAPPC11 trafficking protein particle complex 11
UNKL unkempt family zinc finger-like
VEZT vezatin, adherens junctions transmembrane protein
WASF3 WAS protein family, member 3
WDR33 WD repeat domain 33
YOD1 YOD1 deubiquitinase
ZBTB39 zinc finger and BTB domain containing 39
ZNF215 zinc finger protein 215
ZNF480 zinc finger protein 480
ZNF671 zinc finger protein 671
ZNF701 zinc finger protein 701