mephenesin-7374 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the mephenesin-7374 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRB2 adhesion G protein-coupled receptor B2
AHI1 Abelson helper integration site 1
ALPPL2 alkaline phosphatase, placental-like 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APH1B APH1B gamma secretase subunit
APOC4 apolipoprotein C-IV
APOF apolipoprotein F
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
AXIN1 axin 1
BAX BCL2-associated X protein
BTN3A2 butyrophilin, subfamily 3, member A2
C9ORF9 chromosome 9 open reading frame 9
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCNJ cyclin J
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP164 centrosomal protein 164kDa
CFD complement factor D (adipsin)
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYTH3 cytohesin 3
DENND4A DENN/MADD domain containing 4A
DOPEY2 dopey family member 2
EDAR ectodysplasin A receptor
EGF epidermal growth factor
ELL elongation factor RNA polymerase II
ENOX1 ecto-NOX disulfide-thiol exchanger 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ETV1 ets variant 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM69A family with sequence similarity 69, member A
FGFR4 fibroblast growth factor receptor 4
FNDC4 fibronectin type III domain containing 4
GNL1 guanine nucleotide binding protein-like 1
GPM6B glycoprotein M6B
GPR27 G protein-coupled receptor 27
HBB hemoglobin, beta
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HMGN5 high mobility group nucleosome binding domain 5
HMHA1 histocompatibility (minor) HA-1
HOXC4 homeobox C4
IDS iduronate 2-sulfatase
IFNA6 interferon, alpha 6
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL24 interleukin 24
KDM4B lysine (K)-specific demethylase 4B
KRT6B keratin 6B, type II
LINC00260 long intergenic non-protein coding RNA 260
LRRK1 leucine-rich repeat kinase 1
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAP1B microtubule-associated protein 1B
MAP2K5 mitogen-activated protein kinase kinase 5
MAPT microtubule-associated protein tau
MED16 mediator complex subunit 16
MRAS muscle RAS oncogene homolog
MTHFSD methenyltetrahydrofolate synthetase domain containing
NDRG2 NDRG family member 2
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NR1H4 nuclear receptor subfamily 1, group H, member 4
OASL 2'-5'-oligoadenylate synthetase-like
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCCA propionyl CoA carboxylase, alpha polypeptide
PEX3 peroxisomal biogenesis factor 3
PGM5 phosphoglucomutase 5
PIP prolactin-induced protein
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PML promyelocytic leukemia
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PTCRA pre T-cell antigen receptor alpha
RAB36 RAB36, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SETD8 SET domain containing (lysine methyltransferase) 8
SKAP1 src kinase associated phosphoprotein 1
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC16A4 solute carrier family 16, member 4
SND1-IT1 SND1 intronic transcript 1
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRRM2 serine/arginine repetitive matrix 2
TBC1D2B TBC1 domain family, member 2B
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRAPPC13 trafficking protein particle complex 13
TUBA3C tubulin, alpha 3c
UBE3B ubiquitin protein ligase E3B
WDR61 WD repeat domain 61
ZFP36L1 ZFP36 ring finger protein-like 1
ZKSCAN5 zinc finger with KRAB and SCAN domains 5
ZNF155 zinc finger protein 155
ZNF428 zinc finger protein 428
ZNF606 zinc finger protein 606

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADCY7 adenylate cyclase 7
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALPK1 alpha-kinase 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARRB2 arrestin, beta 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BOLA1 bolA family member 1
C19ORF40 chromosome 19 open reading frame 40
C9ORF91 chromosome 9 open reading frame 91
CAPN15 calpain 15
CBX7 chromobox homolog 7
CCDC25 coiled-coil domain containing 25
CCDC68 coiled-coil domain containing 68
CCNE1 cyclin E1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD70 CD70 molecule
CDH7 cadherin 7, type 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLEC10A C-type lectin domain family 10, member A
CLSPN claspin
CNPY3 canopy FGF signaling regulator 3
CPA4 carboxypeptidase A4
CTAGE9 CTAGE family, member 9
CTSK cathepsin K
CTSV cathepsin V
CUL9 cullin 9
DBR1 debranching RNA lariats 1
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
ELOVL4 ELOVL fatty acid elongase 4
ELSPBP1 epididymal sperm binding protein 1
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
FER fer (fps/fes related) tyrosine kinase
FHOD1 formin homology 2 domain containing 1
FSD1 fibronectin type III and SPRY domain containing 1
GALK1 galactokinase 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLDC glycine dehydrogenase (decarboxylating)
GPR137B G protein-coupled receptor 137B
HELZ helicase with zinc finger
HIST1H2AM histone cluster 1, H2am
HYI hydroxypyruvate isomerase (putative)
IMPACT impact RWD domain protein
INF2 inverted formin, FH2 and WH2 domain containing
KCTD7 potassium channel tetramerization domain containing 7
KIAA0753 KIAA0753
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MANBA mannosidase, beta A, lysosomal
MBD5 methyl-CpG binding domain protein 5
MFSD10 major facilitator superfamily domain containing 10
MRPL44 mitochondrial ribosomal protein L44
MT1M metallothionein 1M
NOL12 nucleolar protein 12
NOTCH1 notch 1
NT5M 5',3'-nucleotidase, mitochondrial
NUBPL nucleotide binding protein-like
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PCSK7 proprotein convertase subtilisin/kexin type 7
PLCD1 phospholipase C, delta 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PMM1 phosphomannomutase 1
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFX7 regulatory factor X, 7
RIN1 Ras and Rab interactor 1
SETBP1 SET binding protein 1
SGMS1 sphingomyelin synthase 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPAG4 sperm associated antigen 4
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STIM1 stromal interaction molecule 1
SYNPO synaptopodin
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TM7SF2 transmembrane 7 superfamily member 2
TMEM51 transmembrane protein 51
TMEM8B transmembrane protein 8B
TOR4A torsin family 4, member A
TRIM26 tripartite motif containing 26
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
UGT8 UDP glycosyltransferase 8
USF2 upstream transcription factor 2, c-fos interacting
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WNT10B wingless-type MMTV integration site family, member 10B
WNT7A wingless-type MMTV integration site family, member 7A
YEATS2 YEATS domain containing 2
ZNF254 zinc finger protein 254
ZNF263 zinc finger protein 263
ZNF329 zinc finger protein 329
ZNF350 zinc finger protein 350
ZNF671 zinc finger protein 671
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
ZXDC ZXD family zinc finger C