mepenzolate bromide-2169 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the mepenzolate bromide-2169 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABHD2 abhydrolase domain containing 2
ABLIM1 actin binding LIM protein 1
ADRA1A adrenoceptor alpha 1A
AHI1 Abelson helper integration site 1
AIRE autoimmune regulator
ATP10A ATPase, class V, type 10A
ATP13A2 ATPase type 13A2
BIRC3 baculoviral IAP repeat containing 3
BMP1 bone morphogenetic protein 1
CA9 carbonic anhydrase IX
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CD22 CD22 molecule
CFAP74 cilia and flagella associated protein 74
CHPF chondroitin polymerizing factor
CLCA1 chloride channel accessory 1
CREBZF CREB/ATF bZIP transcription factor
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DAPK1 death-associated protein kinase 1
DDR1 discoidin domain receptor tyrosine kinase 1
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DPYSL3 dihydropyrimidinase-like 3
EDRF1 erythroid differentiation regulatory factor 1
EXOSC2 exosome component 2
FBXO40 F-box protein 40
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF21 fibroblast growth factor 21
FRS3 fibroblast growth factor receptor substrate 3
GIPR gastric inhibitory polypeptide receptor
GPM6B glycoprotein M6B
GPR157 G protein-coupled receptor 157
GRIP2 glutamate receptor interacting protein 2
HAND2-AS1 HAND2 antisense RNA 1 (head to head)
HHLA1 HERV-H LTR-associating 1
HLA-DOA major histocompatibility complex, class II, DO alpha
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IL11 interleukin 11
IL1R2 interleukin 1 receptor, type II
INE1 inactivation escape 1 (non-protein coding)
INO80B INO80 complex subunit B
IRF6 interferon regulatory factor 6
ISG20 interferon stimulated exonuclease gene 20kDa
KDM4B lysine (K)-specific demethylase 4B
KLK1 kallikrein 1
LMF2 lipase maturation factor 2
LOC730101 uncharacterized LOC730101
LTBP4 latent transforming growth factor beta binding protein 4
MAGEA5 melanoma antigen family A5
MAST2 microtubule associated serine/threonine kinase 2
MCM3AP minichromosome maintenance complex component 3 associated protein
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFAP3L microfibrillar-associated protein 3-like
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MR1 major histocompatibility complex, class I-related
MVP major vault protein
MXD4 MAX dimerization protein 4
NEUROG2 neurogenin 2
NOD2 nucleotide-binding oligomerization domain containing 2
NOP16 NOP16 nucleolar protein
NOVA2 neuro-oncological ventral antigen 2
OR10H3 olfactory receptor, family 10, subfamily H, member 3
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PDE4DIP phosphodiesterase 4D interacting protein
PLCD1 phospholipase C, delta 1
POU2F2 POU class 2 homeobox 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRPF18 pre-mRNA processing factor 18
RAB6A RAB6A, member RAS oncogene family
RB1 retinoblastoma 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REC8 REC8 meiotic recombination protein
RPL23AP53 ribosomal protein L23a pseudogene 53
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RUFY3 RUN and FYVE domain containing 3
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEC14L1 SEC14-like 1 (S. cerevisiae)
SELPLG selectin P ligand
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMAD3 SMAD family member 3
SOCS1 suppressor of cytokine signaling 1
SPDEF SAM pointed domain containing ETS transcription factor
SPTB spectrin, beta, erythrocytic
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
TAS2R1 taste receptor, type 2, member 1
TAS2R10 taste receptor, type 2, member 10
TNK1 tyrosine kinase, non-receptor, 1
TRIM29 tripartite motif containing 29
TRPV5 transient receptor potential cation channel, subfamily V, member 5
UBOX5 U-box domain containing 5
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
UROD uroporphyrinogen decarboxylase
ZER1 zyg-11 related, cell cycle regulator
ZNF428 zinc finger protein 428

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADGRG2 adhesion G protein-coupled receptor G2
AOAH acyloxyacyl hydrolase (neutrophil)
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C22ORF29 chromosome 22 open reading frame 29
C2ORF27A chromosome 2 open reading frame 27A
C5 complement component 5
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC85C coiled-coil domain containing 85C
CD34 CD34 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CDKL3 cyclin-dependent kinase-like 3
CEP131 centrosomal protein 131kDa
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLCN2 chloride channel, voltage-sensitive 2
CNR2 cannabinoid receptor 2 (macrophage)
CTRL chymotrypsin-like
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DDN dendrin
DUSP8 dual specificity phosphatase 8
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFCAB2 EF-hand calcium binding domain 2
ENO3 enolase 3 (beta, muscle)
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
FAM188A family with sequence similarity 188, member A
GEMIN8 gem (nuclear organelle) associated protein 8
GID4 GID complex subunit 4
GPR19 G protein-coupled receptor 19
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRPR gastrin-releasing peptide receptor
HIST1H2AI histone cluster 1, H2ai
IFT81 intraflagellar transport 81
INA internexin neuronal intermediate filament protein, alpha
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
JUP junction plakoglobin
KDM5C lysine (K)-specific demethylase 5C
KLK5 kallikrein-related peptidase 5
LIMD2 LIM domain containing 2
LIMS2 LIM and senescent cell antigen-like domains 2
LRRC20 leucine rich repeat containing 20
LRRK1 leucine-rich repeat kinase 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEH1 melanoma antigen family H1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MLLT4-AS1 MLLT4 antisense RNA 1 (head to head)
MUC3A mucin 3A, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NBEA neurobeachin
NDE1 nudE neurodevelopment protein 1
NKX3-2 NK3 homeobox 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARG poly (ADP-ribose) glycohydrolase
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLP1 proteolipid protein 1
PODNL1 podocan-like 1
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
PORCN porcupine homolog (Drosophila)
PRICKLE3 prickle homolog 3 (Drosophila)
RRAGB Ras-related GTP binding B
S1PR4 sphingosine-1-phosphate receptor 4
SCAMP4 secretory carrier membrane protein 4
SCAMP5 secretory carrier membrane protein 5
SCGB2A2 secretoglobin, family 2A, member 2
SENP7 SUMO1/sentrin specific peptidase 7
SLC22A14 solute carrier family 22, member 14
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SOX12 SRY (sex determining region Y)-box 12
SPAG4 sperm associated antigen 4
STEAP3 STEAP family member 3, metalloreductase
SUGP1 SURP and G patch domain containing 1
SV2A synaptic vesicle glycoprotein 2A
SYCP2 synaptonemal complex protein 2
THBS3 thrombospondin 3
TIGD6 tigger transposable element derived 6
TIMP2 TIMP metallopeptidase inhibitor 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM180 transmembrane protein 180
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOLLIP toll interacting protein
TOM1 target of myb1 (chicken)
TRIM25 tripartite motif containing 25
TRIM45 tripartite motif containing 45
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBQLN4 ubiquilin 4
WASF3 WAS protein family, member 3
WNT16 wingless-type MMTV integration site family, member 16
ZBTB22 zinc finger and BTB domain containing 22
ZFHX2 zinc finger homeobox 2
ZNF197 zinc finger protein 197
ZNF696 zinc finger protein 696
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76
ZNF768 zinc finger protein 768